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Immobilized nucleic acid hybridization reagent and method

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12Q-001/68
  • C12M-001/34
  • C07H-021/04
출원번호 US-0482607 (2000-01-14)
발명자 / 주소
  • Cass Anthony,GBX
  • Valat Christophe,GBX
  • Steel Adam
출원인 / 주소
  • Gene Logic, Inc.
대리인 / 주소
    Foley & Lardner
인용정보 피인용 횟수 : 44  인용 특허 : 9

초록

A fluorescently labeled nucleic acid having a hairpin structure between the fluorophore label and a point of attachment to a solid phase is useful as a probe to detect nucleic acid from a sample. The solid phase quenches the fluorophore label when the hairpin structure exists but this quenching is r

대표청구항

[ We claim:] [1.]1. A method for detecting the presence of a nucleic acid in a test sample, comprising:(a) providing a solid phase having an oligonucleotide bound thereon wherein the oligonucleotide comprises a fluorophore, the fluorophore being covalently attached to one end of the oligonucleotide

이 특허에 인용된 특허 (9)

  1. Kambara Hideki,JPX ; Okano Kazunori,JPX ; Nasu Hisanori,JPX, DNA sequencing by extension of probe chip immobilized oligonucleotides.
  2. Pirrung Michael C. (Durham NC) Read J. Leighton (Palo Alto CA) Fodor Stephen P. A. (Palo Alto CA) Stryer Lubert (Stanford CA), Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof.
  3. Kidwell David A. (Alexandria VA), Light emission-or absorbance-based binding assays for polynucleic acids.
  4. Beattie Kenneth L., Microfabricated, flowthrough porous apparatus for discrete detection of binding reactions.
  5. Meade Thomas J. ; Kayyem Jon Faiz ; Fraser Scott E., Nucleic acid mediated electron transfer.
  6. Patonay Gabor ; Narayanan Narasimhachari ; Strekowski Lucjan ; Middendorf Lyle Richard ; Lipowska Malgorzata, Sequencing near infrared and infrared fluorescence labeled DNA for detecting using laser diodes and suitable labels the.
  7. Patonay Gabor (Stone Mountain GA) Narayanan Narasimhachari (Lincoln NE) Strekowski Lucjan (Stone Mountain GA) Middendorf Lyle R. (Lincoln NE) Lipowska Malgorzata (Decatur GA), Sequencing near infrared and infrared fluorescense labeled DNA for detecting using laser diodes and suitable labels ther.
  8. Finlan, Martin F.; Brady, Michael A. W., Surface plasmon resonance sensors.
  9. Tyagi Sanjay ; Kramer Fred R. ; Marras Salvatore A. E., Wavelength-shifting probes and primers and their use in assays and kits.

이 특허를 인용한 특허 (44)

  1. Horn, Carina; Hoenes, Joachim; Spinke, Jürgen, Amine-N-oxide redox indicators for fluorimetric determination of analytes.
  2. Rahbar-Dehghan, Fariborz, Ceramic biomolecule imaging chip.
  3. He, Chuan; Song, Chunxiao, Composition and methods related to modification of 5-hydroxymethylcytosine (5-hmC).
  4. Miller, Benjamin L.; Krauss, Todd D.; Rothberg, Lewis J.; Peng, Hsin-I, DNA microarray having hairpin probes tethered to nanostructured metal surface.
  5. Jeddeloh, Jeffrey A.; Lakey, Nathan D., Differential enzymatic fragmentation.
  6. Jeddeloh, Jeffrey A.; Lakey, Nathan D., Differential enzymatic fragmentation.
  7. Horn, Carina; Hoenes, Joachim; Spinke, Jürgen, Fluorimetric determination of analytes by amine-N-oxides as redox indicators.
  8. Breidenthal, Scott S.; Fan, Sara H.; Lee, Richard S.; Nelson, Norman C.; Scott, Matthew J.; Taylor, Jason A., Gravity-assisted mixing methods.
  9. Breidenthal, Scott S.; Lee, Richard S.; Nelson, Norman C.; Scott, Matthew J.; Taylor, Jason A.; Fan, Sara H., Gravity-assisted mixing methods.
  10. Bawendi, Moungi G.; Jensen, Klavs F.; Dabbousi, Bashir O.; Rodriguez-Viejo, Javier; Mikulec, Frederic Victor, Highly luminescent color-selective nanocrystalline materials.
  11. Bawendi, Moungi G.; Jensen, Klavs F.; Dabbousi, Bashir O.; Rodriguez-Viejo, Javier; Mikulec, Frederic Victor, Highly luminescent color-selective nanocrystalline materials.
  12. Bawendi, Moungi G.; Jensen, Klavs F.; Dabbousi, Bashir O.; Rodriguez-Viejo, Javier; Mikulec, Frederic Victor, Highly luminescent color-selective nanocrystalline materials.
  13. Bawendi, Moungi G.; Jensen, Klavs F.; Dabbousi, Bashir O.; Rodriguez-Viejo, Javier; Mikulec, Frederic Victor, Highly luminescent color-selective nanocrystalline materials.
  14. Bawendi, Moungi G.; Jensen, Klavs F.; Dabbousi, Bashir O.; Rodriquez Viejo, Javier; Mikulec, Frederic Victor, Highly luminescent color-selective nanocrystalline materials.
  15. Bawendi, Moungi; Jensen, Klavs F.; Dabbousi, Bashir O.; Rodriguez-Viejo, Javier; Mikulec, Frederic Victor, Highly luminescent color-selective nanocrystalline materials.
  16. Bawendi, Moungi; Jensen, Klavs F.; Dabbousi, Bashir O.; Rodriguez-Viejo, Javier; Mikulec, Frederic Victor, Highly luminescent color-selective nanocrystalline materials.
  17. Miller, Benjamin L.; Strohsahl, Christopher M., Hybridization-based biosensor containing hairpin probes and use thereof.
  18. Breidenthal, Scott S.; Fan, Sara H.; Lee, Richard S.; Nelson, Norman C.; Poirier, Michael S.; Scott, Matthew J.; Taylor, Jason A., Instruments and methods for exposing a receptacle to multiple thermal zones.
  19. Breidenthal, Scott S.; Fan, Sara H.; Lee, Richard S.; Nelson, Norman C.; Scott, Matthew J.; Taylor, Jason A., Instruments and methods for mixing the contents of a detection chamber.
  20. Breidenthal, Scott S.; Fan, Sara H.; Lee, Richard S.; Nelson, Norman C.; Scott, Matthew J.; Taylor, Jason A., Instruments and methods for mixing the contents of a detection chamber.
  21. Breidenthal, Scott S.; Fan, Sara H.; Lee, Richard S.; Nelson, Norman C.; Scott, Matthew J.; Taylor, Jason A., Instruments and methods for mixing the contents of a detection chamber.
  22. Fan, Sara H.; Lee, Richard S., Instruments for mixing the contents of a detection chamber.
  23. Hassibi, Arjang, Integrated semiconductor bioarray.
  24. Miller, Benjamin L.; Strohsahl, Christopher M., Method of identifying hairpin DNA probes by partial fold analysis.
  25. Miller,Benjamin L.; Strohsahl,Christopher M., Method of identifying hairpin DNA probes by partial fold analysis.
  26. Iwaki,Yoshihide; Shinoki,Hiroshi; Seshimoto,Osamu; Nakamura,Kouki, Method of reducing background in fluoresence detection.
  27. Firmin, Andrew; Sorge, Joseph A., Methods and compositions for detection of a target nucleic acid sequence utilizing a probe with a 3' flap.
  28. Breidenthal, Scott S.; Fan, Sara H.; Lee, Richard S.; Nelson, Norman C.; Scott, Matthew J.; Taylor, Jason A., Methods and instruments for processing a sample in a multi-chambered receptacle.
  29. Hassibi, Arjang; Jirage, Kshama; Manickam, Arun; Singh, Rituraj, Methods and systems for multiplex quantitative nucleic acid amplification.
  30. Hassibi, Arjang; Jirage, Kshama; Manickam, Arun; Singh, Rituraj, Methods and systems for multiplex quantitative nucleic acid amplification.
  31. Okamoto,Tadashi; Yamamoto,Nobuko; Suzuki,Tomohiro, Methods for evaluating probe arrays.
  32. Nelson, Norman C.; Roma, Gianluca, Methods for manipulating liquid substances in multi-chambered receptacles.
  33. Nelson, Norman C.; Roma, Gianluca, Methods for manipulating liquid substances in multi-chambered receptacles.
  34. Jeddeloh, Jeffrey A.; Lakey, Nathan D., Methods for quantitative determination of methylation density in a DNA locus.
  35. Breidenthal, Scott S.; Fan, Sara H.; Lee, Richard S.; Nelson, Norman C.; Scott, Matthew J.; Taylor, Jason A., Methods of concentrating an analyte.
  36. Reich, Norbert, Methods of using labeled probe molecules to quantify target molecules.
  37. Leproust,Eric M.; Hirschberg,David L.; Delenstarr,Glenda C., Micro arrays with structured and unstructured probes.
  38. Hassibi, Arjang; Jirage, Kshama; Manickam, Arun; Milaninia, Kaveh, Multiplexed analysis of nucleic acid hybridization thermodynamics using integrated arrays.
  39. Stemmler,Ivo; Brecht,Andreas; Gauglitz,Gunter; Steinwand,Michael, Quantitative determination of analytes in a heterogeneous system.
  40. Weiss, Shimon; Bruchez, Marcel; Alivisatos, Paul, Semiconductor nanocrystal probes for biological applications and process for making and using such probes.
  41. Weiss, Shimon; Bruchez, Marcel; Alivisatos, Paul, Semiconductor nanocrystal probes for biological applications and process for making and using such probes.
  42. Weiss, Shimon; Bruchez, Marcel; Alivisatos, Paul, Semiconductor nanocrystal probes for biological applications and process for making and using such probes.
  43. Weiss, Shimon; Bruchez, Marcel; Alivisatos, Paul A., Semiconductor nanocrystal probes for biological applications and process for making and using such probes.
  44. Kang, Kyung A.; Nantz, Michael H., Site specific fluorescence and contrast marker for same.
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