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Method for administering insulin to the brain 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-038/00
  • A61K-009/00
  • C07K-005/00
  • C07K-007/00
출원번호 US-0374801 (1999-08-16)
발명자 / 주소
  • Frey
  • II William H.
출원인 / 주소
  • Chiron Corporation
대리인 / 주소
    Spruill
인용정보 피인용 횟수 : 62  인용 특허 : 17

초록

Disclosed is a method for transporting neurologic therapeutic agents to the brain by means of the olfactory neural pathway and a pharmaceutical composition useful in the treatment of brain disorders.

대표청구항 ▼

[ What is claimed:] [1.]1. A method for transporting an insulin to the brain of a mammal, comprising:applying a pharmaceutical composition comprising the insulin to an upper third of a nasal cavity of the mammal, wherein the insulin is absorbed through a nasal mucosa and transported to the brain of

이 특허에 인용된 특허 (17)

  1. Knauf Suzanne (Fairport NY), Antigen derived from human ovarian tumors and radioimmunoassay using the antigen.
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  2. Bodor Nicholas S. (Gainesville FL), Brain-specific drug delivery.
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  3. Pardridge William M. (Pacific Palisades CA) Schimmel Paul R. (Lexington MA), Chimeric peptides for neuropeptide delivery through the blood-brain barrier.
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  4. Pardridge William M. (Van Nuys CA), Chimeric peptides for neuropeptide delivery through the blood-brain barrier.
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  5. Gibby Wendell A. (7025 N. Via Assisi Tucson AZ 85704), Contrast enhancing agents for magnetic resonance images.
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  6. Carey Martin C. (Wellesley MA) Moses Alan C. (Waban MA) Flier Jeffrey S. (West Newton MA), Drug administration.
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  7. Cox Michael T. (Congleton GB2), Homocyclic derivatives.
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  8. David Gary S. (La Jolla CA) Greene Howard E. (Carlsbad CA), Immunometric assays using monoclonal antibodies.
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  9. della Valle Francesco (Padova ITX) Romeo Aurelio (Rome ITX), Kit or device and method for administering gangliosides and derivatives thereof by inhalation and pharmaceutical composi.
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  10. Arai Motoharu (Tokyo JPX) Ito Masatsugu (Tokyo JPX), Lipid powder having cross-linked coating thereon and process for preparing same.
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  11. Yiournas Costas (Vineland NJ) Wallach Donald F. H. (Brookline MA), Method and apparatus for producing lipid vesicles.
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  12. Frey ; II William H. (North Oaks MN), Method for administering neurologic agents to the brain.
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  13. Pukel Clifford S. (Flushing NY) Lloyd Kenneth O. (Bronx NY) Travassos Luiz R. (Sao Palo BRX) Dippold Wolfgang G. (Mainz CT DEX) Oettgen Herbert F. (New Canaan CT) Old Lloyd J. (New York NY), Method for detecting the presence of GD3 ganglioside.
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  14. Reisfeld Ralph A. (La Jolla CA) Schulz Gregor (San Diego CA), Monoclonal antibody directed to human ganglioside GD2.
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  15. Seckinger Karl (Riegel DEX), N′-[4-(1-Fluoromethyl-ethyl)phenyl]-urea derivatives.
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  16. Glenner George G. (La Jolla CA) Wong Caine W. (Cardiff CA), Polypeptide marker for Alzheimer\s disease and its use for diagnosis.
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  17. Suzuki Yoshiki (Tokyo JPX) Sekine Kunio (Tokyo JPX) Nagai Tsuneji (Tokyo JPX) Nambu Naoki (Kanagawa JPX) Nishimoto Yuji (Tokyo JPX), Powdery pharmaceutical composition for nasal administration.
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  16. Wolf, Daniel A.; Frey, II, William H.; McIvor, R. Scott; Hanson, Leah R., Intranasal delivery of AAV encoding therapeutic enzymes to the central nervous system for the treatment of lysosomal storage diseases.
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  17. Yeomans, David C.; Carson, Dean; Thirucote, Ramachandran, Magnesium-containing oxytocin formulations and methods of use.
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  18. Fisher, Kenneth M.; Jenkins, David W.; Anand, Ramasubramanian; Desai, Abhishek J., Method and apparatus for interactive routing.
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  21. Frey, II, William H.; Panter, Samuel Scott; Bresin Hanson, Leah Ranae, Method of pre-treating patients for stroke comprising administering metal chelators to the upper one-third of the nasal cavity.
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  22. Frey, II, William H.; Panter, Samuel Scott; Hanson, Leah Ranae Bresin; Roeytenberg, Annina, Method of treating Alzheimer's disease comprising administering deferoxamine (DFO) to the upper one-third of the nasal cavity.
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  23. Frey, II, William H.; Panter, Samuel Scott; Bresin Hanson, Leah Ranae, Method of treating cerebral hemorrhage and subarachnoid hemorrhage comprising administering metal chelators to the upper one-third of the nasal cavity.
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  24. Frey, II, William H.; Panter, Samuel Scott; Bresin Hanson, Leah Ranae, Method of treating lewy body syndrome comprising administering metal chelators to the upper one-third of the nasal cavity.
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  25. Hanson, II, Leah Ranae Bresin; Frey, William H.; Panter, Samuel Scott, Method of treating parkinson's disease comprising administering deferoxamine (DFO) to the upper one-third of the nasal cavity.
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  26. Frey, II, William H.; Panter, Samuel Scott; Bresin Hanson, Leah Ranae, Method of treating progressive supranuclear palsy comprising administering metal chelators to the upper one-third of the nasal cavity.
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  27. Frey, II, William H.; Panter, Samuel Scott; Bresin Hanson, Leah Ranae, Method of treating spinal cord injury comprising administering metal chelators to the upper one-third of the nasal cavity.
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  28. Frey, II, William H.; Panter, Samuel Scott; Bresin Hanson, Leah Ranae, Method of treating stroke comprising administering metal chelators to the upper one-third of the nasal cavity.
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  29. Frey, II, William H.; Panter, Samuel Scott; Bresin Hanson, Leah Ranae, Method of treating traumatic brain injury/head injury comprising administering metal chelators to the upper one-third of the nasal cavity.
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  30. Harmon, Brendan; Waszczak, Barbara Lee; Cooper, Mark, Methods for delivery to the central nervous system of nucleic acid nanoparticles to treat central nervous system disorders.
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  40. McIvor, R. Scott; Belur, Lalitha R.; Low, Walter; Fairbanks, Carolyn; Kozarsky, Karen, Methods to treat mucopolysaccharide type I or deficiency in alpha-L-iduronidase using a recombinant adeno-associated virus encoding alpha-L-iduronidase.
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