초록

are selective NPY Y5 receptor antagonists, useful in the treatment of obesity and the complications associated therewith.

대표청구항 ▼

[ What is claimed is:] [1.]1. A compound of structural formula I: a pharmaceutically acceptable salt thereof, wherein;V, W and Z are independently selected from CH and N;R.sup.1 is H, C.sub.1-3 alkyl, C.sub.1-3 alkoxy, F, or Cl;R.sup.2 is S(O)n R.sup.6, COR.sup.6 or CHO, whereinn is 0, 1 or 2; andR.

[ What is claimed is:] [1.]1. A compound of structural formula I: a pharmaceutically acceptable salt thereof, wherein;V, W and Z are independently selected from CH and N;R.sup.1 is H, C.sub.1-3 alkyl, C.sub.1-3 alkoxy, F, or Cl;R.sup.2 is S(O)n R.sup.6, COR.sup.6 or CHO, whereinn is 0, 1 or 2; andR.sup.6 is N(R.sup.3).sub.2 or C.sub.1-3 alkyl;R.sup.3 is independently H or C.sub.1-3 alkyl;Ar is aryl or heteroaryl;R.sup.4 and R.sup.5 are independently selected from:(1) hydrogen,(2) aryl, either unsubstituted or substituted with(a) halo(b) C.sub.1-3 alkoxy,(c) --N(C.sub.1-3 alkyl).sub.2,(d) C.sub.2-4 alkanoyl, or(e) aryl;(3) nitro,(4) C.sub.1-5 alkyl,(5) C.sub.1-5 alkoxy,(6) hydroxy-C.sub.1-3 alkyl,(7) carboxy,(8) halo,(9) C.sub.1-5 alkylthio,(10) C.sub.1-5 ethoxycarbonyl,(11) pyridylcarbonyl,(12) benzoyl,(13) phenyl-C.sub.1-3 alkoxy,(14) pyridyl, either unsubstituted or substituted with C.sub.1-3 alkyl or C.sub.1-3 alkoxy,(15) C 3-6 cycloalkyl,(16) oxazolyl,(17) thiazolyl,(18) triazolyl or(19) phenoxy.