초록 ▼

A biodegradable polymeric drug carrier micelle composition capable of solubilizing a hydrophobic drug in a hydrophilic environment comprises a biodegradable polymeric drug carrier micelle and a hydrophobic drug wherein the drug is physically trapped within and not covalently bonded to the polymeric

A biodegradable polymeric drug carrier micelle composition capable of solubilizing a hydrophobic drug in a hydrophilic environment comprises a biodegradable polymeric drug carrier micelle and a hydrophobic drug wherein the drug is physically trapped within and not covalently bonded to the polymeric drug carrier micelle. The drug carrying micelle is capable of dissolving in water to form a solution thereof, and the drug carrier comprises an amphiphilic block copolymer having a hydrophilic poly(alkylene oxide) component, and a biodegradable hydrophobic polymer component selected from the group consisting of poly(lactic acid), poly(glycoloc acid), poly(lactic-co-glycolic acid), poly(.epsilon.-caprolactone), a derivative thereof and a mixture thereof. Preferably the amphiphilic block copolymer has a molecular weight in a range of about 1430 to about 6000 Daltons and the hydrophilic component content is in a range of about 50 wt % to about 70 wt % based on the total weight of the block copolymer.

대표청구항 ▼

[ We claim:] [1.]1. A hydrophobic drug solution composition comprising an aqueous solvent carrier containing an effective amount of polymeric micelles which micelles consist essentially of:(a)70 to 99.999999 percent by weight of biodegradable polymeric drug carrier micelles consisting essentially of

[ We claim:] [1.]1. A hydrophobic drug solution composition comprising an aqueous solvent carrier containing an effective amount of polymeric micelles which micelles consist essentially of:(a)70 to 99.999999 percent by weight of biodegradable polymeric drug carrier micelles consisting essentially of an amphiphilic block copolymer consisting of BA diblock, ABA triblock and BAB triblock copolymers wherein the B block polymer component is a hydrophilic poly(alkylene oxide) component, and wherein the A block polymer component is a biodegradable hydrophobic polymer component selected from the group consisting of poly(lactic acid), poly(glycolic acid), poly(lactic-co-glycolic acid), and poly(.epsilon.-caprolactone), wherein the amphiphilic block copolymer has a molecular weight in the range of 1430 to 6000 Daltons and the hydrophilic B block component content is in a range of 50 wt % to 70 wt % based on the total weight of the block copolymer wherein said micelles are composed of a tightly packed hydrophobic polymer core and an outer hydrophilic polymer layer, and(b) 0.000001 to 30 percent by weight of a hydrophobic drug that is physically entrapped within and not covalently bound to said hydrophobic polymer core of said polymeric drug carrier micelles.