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| 국가/구분 | United States(US) Patent 등록 |
|---|---|
| 국제특허분류(IPC7판) |
|
| 출원번호 | US-0912998 (1997-08-11) |
| 발명자 / 주소 |
|
| 출원인 / 주소 |
|
| 대리인 / 주소 |
|
| 인용정보 | 피인용 횟수 : 286 인용 특허 : 439 |
Automated drug discovery protocols, or partially automated protocols, in which matrices with memories serve as the platform on which all manipulations are performed or serve as the repository of information that is transferred to other memories as the synthesized compounds are processed and screened
Automated drug discovery protocols, or partially automated protocols, in which matrices with memories serve as the platform on which all manipulations are performed or serve as the repository of information that is transferred to other memories as the synthesized compounds are processed and screened. Also provided are automated drug discovery units for use in the protocols. The units provide a means for seamless data tracking and include instrumentation and vials with memories for information transfer to other memories in a unit. The units, which are provided herein, include some or all of the following: an automated or manual sorter, microvessels, which contain memories, an automated or semi-automated synthesizer, a microvessel washer/dryer, a manual or automated cleaver for removing compounds from the matrix with memory microvessels, and associated software. The memories may be any of any type, including electromagnetically encodable memories and optical memories, or combinations thereof. The memories may be pre-encoded or may be encodabie during, after or before processing. Also provided are manual and automated methods for sorting matrices with memories.
[ What is claimed:] [1.]1. A system for use in solid phase synthesis comprising:a plurality of combinations of matrices with memories, each combination of matrix with memory comprising a combination of a matrix material for supporting solid phase synthesis and a remotely-accessible memory containing
[ What is claimed:] [1.]1. A system for use in solid phase synthesis comprising:a plurality of combinations of matrices with memories, each combination of matrix with memory comprising a combination of a matrix material for supporting solid phase synthesis and a remotely-accessible memory containing encoded data for uniquely identifying each matrix with memory;an identification station for identifying each matrix with memory when the matrix with memory is disposed within a reading range of the identification station;a plurality of synthesis containers, each synthesis container adapted for receiving one or more selected matrices with memories, each synthesis container containing a solution comprising a building block for solid phase synthesis on the selected matrices with memories;a host computer in electrical communication with the identification station and having a database comprising a plurality of synthesis sequences, each synthesis sequence comprising a plurality of steps for synthesizing a molecule or biological particle from a plurality of building blocks and, each synthesis sequence corresponding to an identified matrix with memory, wherein the host computer determines a destination of the identified matrix with memory, the destination comprising a pre-determined synthesis container of the plurality of synthesis containers; anda positioning means responsive to the host computer for moving the matrix with memory to the predetermined destination.
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