초록 ▼

Implantable medical device having a structure adapted for introduction into a patient wherein the structure is composed of a base material positioned over the structure. The implantable medical device further includes at least one composite layer of a bioactive agent and a polymer material and at le

Implantable medical device having a structure adapted for introduction into a patient wherein the structure is composed of a base material positioned over the structure. The implantable medical device further includes at least one composite layer of a bioactive agent and a polymer material and at least a barrier layer positioned over the composite layer and being of thickness adequate to provide a controlled release of the bioactive agent. The barrier layer being applied by a low energy plasma polymerization process which includes placing the device with the at least one composite layer in a plasma chamber and introducing at least one monomer gas.

대표청구항 ▼

1. An implantable medical device comprising:a structure adapted for introduction into a patient, wherein the structure comprises a base material; at least one layer comprised of at least one bioactive agent in a polymer matrix, applied to at least a portion of the outer surface of said base material

1. An implantable medical device comprising:a structure adapted for introduction into a patient, wherein the structure comprises a base material; at least one layer comprised of at least one bioactive agent in a polymer matrix, applied to at least a portion of the outer surface of said base material; and at least one barrier layer positioned over the layer comprised of at least one bioactive agent in a polymer matrix, said barrier layer having a thickness adequate to provide controlled release of the at least one bioactive agent; wherein said barrier layer is formed in situ by a low energy plasma polymerization process of a monomer gas.