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Evolution of whole cells and organisms by recursive sequence recombination 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12N-015/00
  • C12Q-001/68
  • C07H-021/02
  • C07H-021/04
출원번호 US-0626047 (2000-07-26)
발명자 / 주소
  • Stephen delCardayre
  • Matthew Tobin
출원인 / 주소
  • Maxygen, Inc.
대리인 / 주소
    Norman J. Kruse
인용정보 피인용 횟수 : 43  인용 특허 : 77

초록 ▼

The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/

대표청구항 ▼

1. A method of evolving a cell toward acquisition of a desired property, the method comprising:(a) introducing a library of DNA fragments, which fragments are cloned into copies of an artificial chromosome, into a population of cells; (b) culturing the cells under conditions whereby the DNA fragment

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