초록 ▼

A transdermal drug delivery device for the controlled transdermal delivery of an active pharmaceutical agent. The device comprises a drug delivery device comprising an active pharmaceutical agent and a means for its controlled delivery through the skin; and (B) a silicone pressure sensitive adhesive

A transdermal drug delivery device for the controlled transdermal delivery of an active pharmaceutical agent. The device comprises a drug delivery device comprising an active pharmaceutical agent and a means for its controlled delivery through the skin; and (B) a silicone pressure sensitive adhesive for maintaining contact between the device and the skin of a wearer. The silicone pressure sensitive adhesive comprises silicone resin copolymer and a polydiorganosiloxane and has a silanol concentration in the range of between about 8000 and about 13,000 ppm. The present invention also relates to methods for producing the above silicone pressure sensitive adhesive compositions.

대표청구항 ▼

1. A transdermal drug delivery device for the controlled transdermal delivery of an active pharmaceutical agent comprising:(A) a drug delivery device comprising an active pharmaceutical agent and a means for its controlled delivery through the skin; and (B) a silicone pressure sensitive adhesive for

1. A transdermal drug delivery device for the controlled transdermal delivery of an active pharmaceutical agent comprising:(A) a drug delivery device comprising an active pharmaceutical agent and a means for its controlled delivery through the skin; and (B) a silicone pressure sensitive adhesive for maintaining contact between the device and the skin of a wearer, wherein the silicone pressure sensitive adhesive comprises: (i) between about 40 and about 70 parts by weight of at least one resin copolymer comprising triorganosiloxy units of the formula R3SiO1/2 and tetrafunctional siloxy units of the formula SiO4/2 in a ratio of about 0.6 to 0.9 triorganosiloxy units for each tetrafunctional siloxy unit, wherein each R independently denotes a monovalent hydrocarbon radical having from 1 to 6 carbon atoms; and (ii) between about 30 and about 60 parts by weight of at least one polydiorganosiloxane comprising ARSiO units terminated with endblocking TRASiO1/2 units, wherein the polydiorganosiloxane has a viscosity of from about 100 centipoise to about 30,000,000 centipoise at 25.degree. C. and each R is as above, each A radical is independently selected from R or halohydro-carbon radicals having from 1 to 6 inclusive carbon atoms, each T radical is independently selected from the group consisting of R, OH, H or OR', and each R' is independently an alkyl radical of from 1 to 4 inclusive carbon atoms; wherein the silanol content of the silicone pressure sensitive adhesive composition has been reduced by chemically treating at least a portion of (i), (ii) or the mixture of (i) and (ii) with at least one chemical treating agent (iii) that reacts with silicon-bonded hydroxyl groups to reduce the silicon-bonded hydroxyl content of the composition to a range of between about 8000 and about 13000.