초록 ▼

The present invention relates to tablets which are time-controlled to release active agent at different rates in different regions of the digestive tract in order to maintain a substantially constant concentration in the blood. In one embodiment, a new modified release drug delivery system, for once

The present invention relates to tablets which are time-controlled to release active agent at different rates in different regions of the digestive tract in order to maintain a substantially constant concentration in the blood. In one embodiment, a new modified release drug delivery system, for once a day peroral use, consisting of a solid core comprising an active agent together with a hydrogel, with the solid core being coated with a semi-permeable, self-destructing membrane which is optionally drilled to provide a release orifice, and then optionally further coated with the same or different active agent material. The device delivers the active agent in a substantially constant effective dose for the duration of the transit through the stomach and small intestine, followed by accelerated release when reaching the large intestine.

대표청구항 ▼

1. An oral tablet for delivering a beneficial agent to a mammal, comprising:a core compartment having a beneficial agent; and a unitary self-destructing shell surrounding the core compartment, the self-destructing shell comprising a plurality of disintegrant particles dispersed within a semipermeabl

1. An oral tablet for delivering a beneficial agent to a mammal, comprising:a core compartment having a beneficial agent; and a unitary self-destructing shell surrounding the core compartment, the self-destructing shell comprising a plurality of disintegrant particles dispersed within a semipermeable matrix.