초록 ▼

Fiber delivered laser pulses emulsify thrombus by mechanical stresses that include a combination of pressure, tension and shear stress. Laser radiation is delivered to the locality of a thrombus and the radiation is absorbed by blood, blood dot, or other present materials. The combination of a leadi

Fiber delivered laser pulses emulsify thrombus by mechanical stresses that include a combination of pressure, tension and shear stress. Laser radiation is delivered to the locality of a thrombus and the radiation is absorbed by blood, blood dot, or other present materials. The combination of a leading pressure wave and subsequent vapor bubble cause efficient, emulsification of thrombus. Operating the laser in a low average power mode alleviates potential thermal complications. The laser is operated in a high repetition rate mode to take advantage of ultrasound frequency effects of thrombus dissolution as well as to decrease the total procedure time. Specific parameter ranges for operation are described. The device includes optical fibers surrounding a lumen intended for flow of a cooling agent. The fibers may be arranged concentrically around the lumen to deliver radiation and heat over as large an area as possible. An alternative design approach incorporates the optical fibers into the wall of the guiding catheter and utilizes the catheter lumen as the cooling channel. An eccentric tip enables rotation of the device to address all parts of the vasculature. The eccentricity can be provided via a variety of means: spring dip, balloon, protrusion, etc.

대표청구항 ▼

1. An opto-acoustic recanilization delivery system, comprising:a flexible tubing comprising a first end and a second end, wherein said flexible tubing is suitable for insertion into the vasculature and comprises a lumen for flowing a cooling agent; and a plurality of optical fibers, wherein each fib

1. An opto-acoustic recanilization delivery system, comprising:a flexible tubing comprising a first end and a second end, wherein said flexible tubing is suitable for insertion into the vasculature and comprises a lumen for flowing a cooling agent; and a plurality of optical fibers, wherein each fiber of said plurality of optical fibers comprises a proximal end and a distal end, wherein each said distal end is embedded within said flexible tubing near said second end and wherein at least one fiber of said plurality of optical fibers at said distal end is pointed away from said lumen to target areas other than directly forward looking.