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Method and apparatus for measuring a state variable 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12M-001/42
출원번호 US-0321458 (1999-05-27)
우선권정보 DE-0023655 (1998-05-27); DE-2011066 (1998-06-23)
발명자 / 주소
  • Werner Baumann DE
  • Ralf Ehret DE
  • Mirko Lehmann DE
  • Gunter Igel DE
  • Hans-Jurgen Gahle DE
  • Bernhard Wolf DE
  • Ulrich Sieben DE
  • Ingo Freund DE
  • Martin Brischwein DE
출원인 / 주소
  • Micronas GmbH DE
대리인 / 주소
    Akin, Gump, Strauss, Hauer & Feld, L.L.P.
인용정보 피인용 횟수 : 55  인용 특허 : 6

초록 ▼

A method is provided for measuring a state variable of a biological cell (3) located in a nutrient medium (2) and supported on and adhering to a support area (5). Within the support area (5) for the cell (3) and at a distance from the support area edge, an opening is made in the membrane of the cell

대표청구항 ▼

1. An apparatus for measuring a state variable of at least one biological cell (3) located in a nutrient medium (2), comprising a specimen slide (4) having a support area (5) or which the cell (3) is supportable in an adherent manner, at least one measuring probe for contact with a liquid located in

이 특허에 인용된 특허 (6)

  1. Schmukler Robert E. (13905 Vista Dr. Rockville MD 20853), Apparatus and methods for electroporation and electrofusion.
    상세보기
  2. Leighton Stephen B. (Maplewood NJ) Brownstein Michael J. (Rockville MD), Array-type multiple cell injector.
    상세보기
  3. Kuperstein Michael (Cambridge MA), Microelectrode and assembly for parallel recording of neurol groups.
    상세보기
  4. Ginaven Robert O. (Encinitas CA) Facciotti Daniel (Davis CA), Needle array and method of introducing biological substances into living cells using the needle array.
    상세보기
  5. Hilliard Jeffrey L. (Davis CA) Moloney Maurice M. (Davis CA), Probe for electrofusion, electroporation, or like procedure.
    상세보기
  6. Wolf Bernhard,DEX ; Baumann Werner,DEX ; Dumbs Alfred,DEX ; Sulz Gerd,DEX ; Sieben Ulrich,DEX, Specimen slide for a microscope.
    상세보기

이 특허를 인용한 특허 (55)

  1. Stett,Alfred; Nisch,Wilfried; H��mmerle,Hugo; Knott,Thomas, Apparatus and method for electrically contacting biological cells suspended in a liquid.
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  2. Ando, Moritoshi; Sakai, Satoru, Apparatus and method for injecting substance into cell.
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  3. Okandan, Murat; Galambos, Paul C., Apparatus and method for transforming living cells.
    상세보기
  4. Baumann,Werner; Ehret,Ralf; Lehmann,Mirko; Igel,G��nter; Gahle,Hans J��rgen; Sieben,Ulrich; Freund,Ingo; Brischwein,Martin, Apparatus for intracellular manipulation of a biological cell.
    상세보기
  5. Guazzo, Dana; Wolf, Heinz, At rest vacuum state for vacuum decay leak testing method and system.
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  6. Vassanelli, Stefano; Cellere, Giorgio, Biochip electroporator and its use in multi-site, single-cell electroporation.
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  7. Li, Nan; Wang, Xiaobo; Abassi, Yama A.; Xi, Biao; Zhang, Wen Fu; Xu, Xiao, Data analysis of impedance-based cardiomyocyte-beating signals as detected on real-time cell analysis (RTCA) cardio instruments.
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  8. Wang, Xiaobo; Abassi, Yama A.; Atienza, Josephine; Xu, Xiao; Xu, Junquan, Device and method for electroporation-based delivery of molecules into cells and dynamic monitoring of cell responses.
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  9. Wang, Xiaobo; Abassi, Yama A.; Atienza, Josephine; Xu, Xiao; Xu, Junquan, Device and method for electroporation-based delivery of molecules into cells and dynamic monitoring of cell responses.
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  10. Melosh, Nicholas Alexander; Verma, Piyush; Almquist, Benjamin David, Devices and methods for long-term intracellular access.
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  11. Melosh, Nicholas Alexander; Verma, Piyush; Almquist, Benjamin David, Devices and methods for long-term intracellular access.
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  12. Abassi, Yama A.; Yu, Naichen; Atienza, Josephine; Xu, Xiao; Wang, Xiaobo, Dynamic monitoring of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) activity and pathways in living cells using real-time microelectronic cell sensing technology.
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  13. Abassi, Yama A.; Yu, Naichen; Atienza, Josephine; Xu, Xiao; Wang, Xiabo, Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology.
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  14. Abassi, Yama A.; Yu, Naichen; Atienza, Josephine; Xu, Xiao; Wang, Xiaobo, Dynamic monitoring of activation of receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology.
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  15. Wang, Xiaobo; Abassi, Yama; Atienza, Josephine; Xu, Xiao, Dynamic monitoring of cell adhesion and spreading using the RT-CES system.
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  16. Tyvoll,David; Childers,Winthrop D., Electrical analysis of biological membranes.
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  17. Takenaka, Shigeori; Uchida, Kazuhiko; Miyahara, Takatoshi, Gene detecting chip, detector, and detecting method.
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  18. Kobori, Shinichi; Nakama, Kazuhiro; Satoh, Shingo; Miyahara, Hiroyoshi, Gene detection chip and detection device.
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  19. Ito, Tetsumasa, Gene detection system, gene detection device comprising same, detection method, and gene detecting chip.
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  20. Owen, David Geraint; Byrne, Nicholas Gerard, High throughput screen.
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  21. Owen, David Geraint; Byrne, Nicholas Gerard, High throughput screen.
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  22. Owen, David Geraint; Byrne, Nicholas Gerard, High throughput screen.
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  23. Owen, David Geraint; Byrne, Nicholas Gerard, High throughput screen.
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  24. Schroeder,Kirk S.; Neagle,Bradley D., High-throughput electrophysiological measurement system.
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  25. Wang,Xiaobo; Xu,Xiao, Impedance based apparatuses and methods for analyzing cells and particles.
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  26. Wang, Xiaobo; Xu, Xiao, Impedance based devices and methods for use in assays.
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  27. Xu,Xiao; Wang,Xiaobo, Impedance based devices and methods for use in assays.
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  28. Wang, Xiaobo; Abassi, Yama A.; Xi, Biao; Zhang, Wen Fu; Xu, Xiao, Label-free monitoring of excitation-contraction coupling and excitable cells using impedance based systems with millisecond time resolution.
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  29. Wang, Xiaobo; Abassi, Yama A.; Xi, Biao; Zhang, Wen Fu; Xu, Xiao, Label-free monitoring of excitation-contraction coupling and excitable cells using impedance based systems with millisecond time resolution.
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  30. Kobori, Shinichi; Nakama, Kazuhiro; Miyahara, Hiroyoshi, METHOD FOR SURFACE TREATMENT OF GOLD-PLATED BODY AND SURFACE-TREATED PRODUCT, AND PROCESS FOR PRODUCING GOLD-PLATED BODY AND GOLD-PLATED BODY, AND METHOD FOR IMMOBILIZATION OF SULFUR-CONTAINING MOLEC.
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  31. Xu,Xiao; Abassi,Yama; Wang,Xiaobo, Method for assaying for natural killer, cytotoxic T-lymphocyte and neutrophil-mediated killing of target cells using real-time microelectronic cell sensing technology.
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  32. Kobori,Shinichi; Nakama,Kazuhiro; Miyahara,Hiroyoshi, Method for surface treatment of gold-plated body and surface-treated product and process for producing gold-plated body and gold-plated body, and method for immobilization of sulfur-containing molecules.
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  33. Nakayama,Masato, Method of detecting nucleotide mutations.
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  34. Abassi, Yama A.; Yu, Naichen; Atienza, Josephine; Xu, Xiao; Wang, Xiaobo, Method of measuring cell-substrate impedance in living cells to identify compounds affecting receptor tyrosine kinase (RTK) activity and pathways.
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  35. Osipchuk, Yuri, Method of positioning cells for electrophysiological testing.
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  36. Okandan, Murat, Micromachined patch-clamp apparatus.
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  37. Vogel,Horst; Schmidt,Christian, Multiaperture sample positioning and analysis system.
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  38. Vogel,Horst; Schmidt,Christian, Multiaperture sample positioning and analysis system.
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  39. Jardemark, Kent; Jesorka, Aldo; Karlsson, Mattias; Olofsson, Jessica; Orwar, Owe; Pihl, Johan; Sahlin, Eskil, Nanoelectrodes and nanotips for recording transmembrane currents in a plurality of cells.
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  40. VanDersarl, Jules J.; Xu, Alexander M.; Melosh, Nicholas A.; Tayebi, Noureddine, Nanotube structures, methods of making nanotube structures, and methods of accessing intracellular space.
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  41. Vandersarl, Jules J.; Xu, Alexander M.; Melosh, Nicholas A.; Tayebi, Noureddine, Nanotube structures, methods of making nanotube structures, and methods of accessing intracellular space.
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  42. Klemic, Kathryn G.; Klemic, James F.; Reed, Mark A.; Sigworth, Frederick J., Planar patch clamp electrodes.
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  43. Vogel, Horst; Schmidt, Christian, Positioning and electrophysiological characterization of individual cells and reconstituted membrane systems on microstructured carriers.
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  44. Wang, Xiaobo; Abassi, Yama A.; Xu, Xiao; Gan, Jiangbo, Real time electronic cell sensing system and applications for cell-based assays.
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  45. Abassi, Yama A.; Wang, Xiaobo; Xu, Xiao, Real time electronic cell sensing system and applications for cytotoxicity profiling and compound assays.
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  46. Abassi, Yama A.; Wang, Xiaobo; Xu, Xiao, Real time electronic cell sensing system and applications for cytotoxicity profiling and compound assays.
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  47. Wang, Xiaobo; Xu, Xiao; Abassi, Yama, Real time electronic cell sensing system and applications for cytotoxicity profiling and compound assays.
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  48. Xu, Xiao; Abassi, Yama; Wang, Xiaobo; Gan, Jiangbo, Real time electronic cell sensing systems and applications for cell-based assays.
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  49. Xu,Xiao; Abassi,Yama; Wang,Xiaobo; Gan,Jiangbo, Real time electronic cell sensing systems and applications for cell-based assays.
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  50. Abassi, Yama A.; Wang, Xiaobo; Xu, Xiao, Real-time electronic cell sensing system and applications for cytotoxicity profiling and compound assays.
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  51. Vogel,Horst; Schmidt,Christian, Sample positioning and analysis system.
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  52. Karlsson,Mattias; Orwar,Owe; Chiu,Daniel T.; Sinclair,Jon; Jardemark,Kent; Olofsson,Jessica; Pihl,Johan; Farre,Cecilia, System and method for obtaining and maintaining high-resistance seals in patch clamp recordings.
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  53. Schroeder,Kirk S., System for rapid chemical activation in high-throughput electrophysiological measurements.
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  54. Wang, Xiaobo; Abassi, Yama A.; Zhang, Wen fu; Xu, Xiao, Use of impedance-based cytological profiling to classify cellular response profiles upon exposure to biologically active agents.
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  55. Abassi, Yama A.; Zhao, Li; Ke, Ning; Wang, Xiaobo; Xu, Xiao, Using impedance-based cell response profiling to identify putative inhibitors for oncogene addicted targets or pathways.
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