초록 ▼

The invention provides isolated nucleic acid and amino acid sequences of sensory cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sensory cell specific G-protein coupled receptor

The invention provides isolated nucleic acid and amino acid sequences of sensory cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sensory cell specific G-protein coupled receptors.

대표청구항 ▼

1. An isolated nucleic acid encoding a taste transduction G-protein coupled receptor, wherein the nucleic acid specifically hybridizes under highly stringent conditions to a reference nucleic acid comprising a nucleotide sequence of SEQ ID NO:3, SEQ ID NO:4, or SEQ ID NO:8, wherein the hybridization

1. An isolated nucleic acid encoding a taste transduction G-protein coupled receptor, wherein the nucleic acid specifically hybridizes under highly stringent conditions to a reference nucleic acid comprising a nucleotide sequence of SEQ ID NO:3, SEQ ID NO:4, or SEQ ID NO:8, wherein the hybridization reaction is incubated at 42.degree. C. in a solution comprising 50% formamide, 5.times.SSC, and 1% SDS and washed at 65.degree. C. in a solution comprising 0.2.times.SSC and 0.1% SDS, and wherein the receptor binds to a phenylthiocarbamide ligand.