초록 ▼

Methods and devices are provided for at least reducing the mineral content of a vascular calcified lesion, i.e. a calcified lesion present on the vascular tissue of a host. In the subject methods, the local environment of the lesion is maintained at a subphysiologic pH for a period of time sufficien

Methods and devices are provided for at least reducing the mineral content of a vascular calcified lesion, i.e. a calcified lesion present on the vascular tissue of a host. In the subject methods, the local environment of the lesion is maintained at a subphysiologic pH for a period of time sufficient for the mineral content of the lesion to be reduced, e.g. by flushing the lesion with a fluid capable of locally increasing the proton concentration in the region of the lesion. Also provided are catheters for use in performing the subject methods, where the catheters at least include a first lumen capable of delivering fluid to a vascular site and a second lumen capable of removing fluid from a vascular site. The subject methods and devices find particular use in the treatment of vascular diseases associated with the presence of calcified lesions on vascular tissue.

대표청구항 ▼

1. A catheter comprising:a dissolution fluid introduction lumen comprising an acidic dissolution fluid having a pH of less than about 2, wherein introduction lumen is capable of delivering a dissolution fluid to a vascular tissue site and a fluid removal lumen capable of removing fluid from said vas

1. A catheter comprising:a dissolution fluid introduction lumen comprising an acidic dissolution fluid having a pH of less than about 2, wherein introduction lumen is capable of delivering a dissolution fluid to a vascular tissue site and a fluid removal lumen capable of removing fluid from said vascular tissue site having dimensions sufficient to allow passage of lesion debris.