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Integrated multiplexed capillary electrophoresis system

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • G01N-027/26
출원번호 US-0144170 (1998-08-31)
발명자 / 주소
  • Edward S. Yeung
  • Hongdong Tan
출원인 / 주소
  • Iowa State University Research Foundation, Inc.
대리인 / 주소
    Mueting, Raasch & Gebhardt, P.A.
인용정보 피인용 횟수 : 56  인용 특허 : 9

초록

The present invention provides an integrated multiplexed capillary electrophoresis system for the analysis of sample analytes. The system integrates and automates multiple components, such as chromatographic columns and separation capillaries, and further provides a detector for the detection of ana

대표청구항

1. An integrated multiplexed capillary electrophoresis system for analysis of an analyte in a sample comprising:a plurality of intake capillaries; a plurality of first junctions, each first junction in fluid communication with one of the plurality of intake capillaries; a first manifold in fluid com

이 특허에 인용된 특허 (9)

  1. Yeung Edward S. (Ames IA) Chang Huan-Tsang (Silver Spring MD) Fung Eliza N. (Ames IA), Capillaries for use in a multiplexed capillary electrophoresis system.
  2. Colin Bruno,FRX ; Mandrand Bernard,FRX, Freeze valve and treatment enclosure controlled by at least one such valve.
  3. Bevan Christopher David,GB3 ; Mutton Ian Martin,GB3, Liquid flow management means.
  4. Yeung Edwards (Ames IA) Kuhr Werner G. (Riverside CA), Means and method for capillary zone electrophoresis with laser-induced indirect fluorescence detection.
  5. Drmanac Radoje T. (Beograd YUX) Crkvenjakov Radomir B. (Beograd YUX), Method of sequencing by hybridization of oligonucleotide probes.
  6. Drmanac Radoje T. (Beograd YUX) Crkvenjakov Radomir B. (Beograd YUX), Method of sequencing of genoms by hybridization of oligonucleotide probes.
  7. Yeung Edward S. (Ames IA) Chang Huan-Tsang (Silver Spring MD) Fung Eliza N. (Ames IA) Li Qingbo (Ames IA) Lu Xiandan (Ames IA), Multiplexed capillary electrophoresis system.
  8. Yeung Edward S. ; Li Qingbo ; Lu Xiandan, Multiplexed capillary electrophoresis system.
  9. Swerdlow Harold P. ; Wittwer Carl T., On-line DNA analysis system with rapid thermal cycling.

이 특허를 인용한 특허 (56)

  1. Kawazoe, Hiroshi; Akai, Kunihiko; Yasue, Kiyoshi, Analytical pretreatment device.
  2. Kawazoe, Hiroshi; Akai, Kunihiko; Yasue, Kiyoshi, Analytical pretreatment device.
  3. Hofmann, Martin, Apparatus for analyzing a liquid sample using a multiple-lumen capillary.
  4. Tanaka, Hiroshi, Apparatus for electrophoresis.
  5. Hacker, Kevin J.; Voss, Karl O., Buffers for electrophoresis and use thereof.
  6. Hacker,Kevin J.; Voss,Karl O., Buffers for electrophoresis and use thereof.
  7. Majlof, Lars; Van Gelder, Ezra, Capillary electrophoresis device.
  8. Hayashizaki,Yoshihide; Nakamura,Shin; Hazama,Makoto; Fujiwake,Hideshi, Capillary electrophoretic apparatus, sample plate and sample injection method.
  9. Ogg, James; Eberhart, David; Nielsen, William D.; Franklin, Helen; Jovanovich, Stevan B., Cartridges and instruments for sample analysis.
  10. Guzman, Norberto A., Controlled electrophoresis method.
  11. Kambara, Hideki; Zhou, Guohua; Miyahara, Yuji, DNA base sequencing system.
  12. Rapp, Bastian; Voigt, Achim; Carneiro, Leonardo, Device for controlling the flow of fluids through microfluidic channels.
  13. Kobrin, Boris; Blaga, Iuliu I.; Nielsen, William; Qi, Shize D.; Van Gelder, Ezra, Device with diaphragm valve.
  14. Guzman, Norberto A., Electrophoresis apparatus having an outlet passage.
  15. Guzman, Norberto A., Electrophoresis apparatus having at least one auxiliary buffer passage.
  16. Guzman,Norberto A., Electrophoresis apparatus having staggered passage configuration.
  17. Guzman, Norberto A., Electrophoresis apparatus having valve system.
  18. Guzman, Norberto A., Electrophoresis extraction device.
  19. Guzman, Norberto A., Electrophoresis process using a valve system.
  20. Welle, Richard P., Fast acting valve apparatuses.
  21. Eberhart, David; Nielsen, William D.; Franklin, Helen; Jovanovich, Stevan B.; Lehto, Dennis; Chear, Kaiwan; Klevenberg, James; Park, Chungsoo Charles; Smith, Corey; Wunderle, Philip Justus; King, David, Fluidic cartridge with valve mechanism.
  22. Blaga, Iuliu I.; Jovanovich, Stevan B.; Kobrin, Boris; Van Gelder, Ezra, Fluidic devices with diaphragm valves.
  23. Gerhardt, Geoff C.; Dourdeville, Theodore, Freeze-thaw valve that self-limits cryogenic agent usage.
  24. Yan, Chao; Yao, Dong; Zhang, Lin; Li, Jing, Fully automated high-precision capillary electrophoresis instrument.
  25. Swierkowski, Stefan P., Injector-concentrator electrodes for microchannel electrophoresis.
  26. Stern, Seth; Jovanovich, Stevan B., Linear valve arrays.
  27. Stern, Seth; Jovanovich, Stevan Bogdan, Linear valve arrays.
  28. Takahashi, Katsutoshi; Iida, Kazuhiro; Baba, Masakazu; Iguchi, Noriyuki; Sano, Toru; Kawaura, Hisao; Sakamoto, Toshitsugu; Hattori, Wataru; Someya, Hiroko, Mass spectrometric system and mass spectrometry.
  29. Witt,Klaus, Method and apparatus for analyzing a mixture of sample substances.
  30. Vangbo, Mattias; Nielsen, William D.; Blaga, Iuliu I.; Nguyen, Michael Van; Jovanovich, Steven B., Methods for generating short tandem repeat (STR) profiles.
  31. Jovanovich, Stevan Bogdan; Blaga, Iuliu Ioan, Methods for processing and analyzing nucleic acid samples.
  32. Kawazoe, Hiroshi; Nakaso, Akishi; Arike, Shigeharu, Micro fluid system support and manufacturing method thereof.
  33. Kawazoe, Hiroshi; Nakaso, Akishi; Arike, Shigeharu, Micro fluid system support and manufacturing method thereof.
  34. Jovanovich, Stevan Bogdan; Blaga, Iuliu I.; Nguyen, Michael; Nielsen, William D.; Vangbo, Mattias, Microfluidic and nanofluidic devices, systems, and applications.
  35. Welle, Richard P., Microfluidic device for inducing separations by freezing and associated method.
  36. Boronkay, Allen; Jovanovich, Stevan Bogdan; Blaga, Iuliu Ioan, Microfluidic devices.
  37. Jovanovich, Stevan Bogdan; Blaga, Iuliu Ioan, Microfluidic devices.
  38. Jovanovich, Stevan Bogdan; Blaga, Iuliu Ioan, Microfluidic devices.
  39. Vangbo, Mattias, Microfluidic devices with mechanically-sealed diaphragm valves.
  40. Welle, Richard P., Microfluidic devices with separable actuation and fluid-bearing modules.
  41. Jovanovich, Stevan B.; Nielsen, William D.; Nguyen, Michael Van, Microfluidic methods.
  42. Nordman,Eric S.; Ozawa,Miho; Kojima,Masaya; Inaba,Ryoji; Kodama,Yoshitaka; Yamazaki,Motohiro, Multi-capillary electrophoresis apparatus.
  43. Karp,Christoph D.; Covington,Joseph F.; Gregori,Matthew M.; Hobbs,Steven E.; Koehler,Jeffrey A.; O'Connor,Stephen D.; Patel,Paren P.; Beach,Scott G., Multi-column separation devices and methods.
  44. Guzman,Norberto A., Multi-dimensional electrophoresis apparatus.
  45. Liu, ChangSheng; Le Van, Kevin, Multidimensional separations employing an array of electrophoresis channels.
  46. Hobbs, Steven E.; Duong, Hau H., Parallel detection chromatography systems.
  47. Welle, Richard P., Phase-change valve apparatuses.
  48. Curcio, Mario, Preconcentration interface coupling liquid chromatography to capillary electrophoresis.
  49. Gerhardt, Geoff C.; Jorgenson, James W.; Fadgen, Keith, Sample injector system for liquid chromatography.
  50. Karp,Christoph D.; Pezzuto,Marci; Hobbs,Steven E., Sealing interface for microfluidic device.
  51. Hobbs, Steven E.; Gregori, Matthew M.; Karp, Christoph D.; Koehler, Jeffrey A.; Patel, Paren P.; Covington, Joseph F., Separation column devices and fabrication methods.
  52. Barringer, Jr.,George E., Stationary capillary electrophoresis system.
  53. Jovanovich, Stevan Bogdan; Blaga, Iuliu Ioan, Systems of sample processing having a macro-micro interface.
  54. Jovanovich, Stevan B.; Nielsen, William D.; Cohen, David S.; Recknor, Michael; Vangbo, Mattias; Van Gelder, Ezra; El-Sissi, Omar, Universal sample preparation system and use in an integrated analysis system.
  55. Jovanovich, Stevan B.; Nielsen, William D.; Cohen, David S.; Recknor, Michael; Vangbo, Mattias; Van Gelder, Ezra; Majlof, Lars; El-Sissi, Omar, Universal sample preparation system and use in an integrated analysis system.
  56. Jovanovich, Stevan B.; Nielsen, William D.; Cohen, David S.; Recknor, Michael; Vangbo, Mattias; Van Gelder, Ezra; Majlof, Lars; El-Sissi, Omar, Universal sample preparation system and use in an integrated analysis system.
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