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Matrices for drug delivery and methods for making and using the same 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-009/14
출원번호 US-0503438 (2000-02-14)
발명자 / 주소
  • John W. Babich
  • Jon Zubieta
  • Grant Bonavia
출원인 / 주소
  • Biostream, Inc.
대리인 / 주소
    Foley, Hoag & Eliot, LLP
인용정보 피인용 횟수 : 83  인용 특허 : 30

초록 ▼

In one aspect, biocompatible matrices such as sol-gels encapsulating a reaction center may be administered to a subject for conversion of prodrugs into biologically active agents. In certain embodiments, the biocompatible matrices of the present invention are sol-gels. In one embodiment, the enzyme

대표청구항 ▼

1. A method for producing a biologically active agent from a prodrug, comprising: a. encapsulating a first cell-free reaction center in a biocompatible matrix; and b. administering said biocompatible matrix to a subject; wherein said biocompatible matrix comprises an inorganic-based sol-gel matrix

이 특허에 인용된 특허 (30)

  1. Burke Philip J. (Charlton GBX) Dowell Robert I. (Congleton MD GBX) Mauger Anthony B. (Kensington MD) Springer Caroline J. (London GBX), Chemical compounds.
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  2. Burke Philip John,GBX ; Dowell Robert Ian,GBX ; Mauger Anthony Brian ; Springer Caroline Joy,GBX, Chemical compounds.
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  3. Avnir David (Jerusalem ILX) Ottolenghi Michael (Jerusalem ILX) Lev Ovadia (Jerusalem ILX), Chromatography processes using doped sol gel glasses as chromatographic media.
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  4. Baetge Edward E. (Barrington RI) Hammang Joseph P. (Barrington RI) Gentile Frank T. (Warwick RI) Lindner Mark D. (Bristol RI) Winn Shelley R. (Smithfield RI) Emerich Dwaine F. (Providence RI), Compositions and methods for the delivery of biologically active molecules using cells contained in biocompatible capsul.
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  5. Baetge Edward E. (Barrington RI) Hammang Joseph P. (Barrington RI) Gentile Frank T. (Warwick RI) Lindner Mark D. (Bristol RI) Winn Shelley R. (Smithfield RI) Emerich Dwaine F. (Providence RI), Compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in.
    상세보기
  6. Sabel Bernhard A. (Munich MA DEX) Freese Andrew (Jamaica Plain MA) Saltzman William M. (Somerville MA), Controlled drug delivery system for treatment of neural disorders.
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  7. Baetge Edward E. (Barrington RI) Hammang Joseph P. (Barrington RI) Gentile Frank T. (Warwick RI) Lindner Mark D. (Bristol RI) Winn Shelley R. (Smithfield RI) Emerich Dwaine F. (Providence RI), Delivery of biologically active molecules using cells contained in biocompatible immunoisolatory capsules.
    상세보기
  8. Avnir David (Jerusalem ILX) Ottolenghi Michael (Jerusalem ILX) Braun Sergei (Jerusalem ILX) Zusman Rivka (Jerusalem ILX), Doped sol-gel glasses for obtaining chemical interactions.
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  9. Avnir David (Jerusalem ILX) Ottolenghi Michael (Jerusalem ILX) Braun Sergei (Jerusalem ILX) Zusman Rivka (Jerusalem ILX), Doped sol-gel glasses for obtaining chemical interactions.
    상세보기
  10. Avnir David (Jerusalem ILX) Ottolenghi Michael (Jerusalem ILX) Braun Sergei (Jerusalem ILX) Zusman Riyka (Jerusalem ILX), Doped sol-gel glasses for obtaining chemical interactions.
    상세보기
  11. Avnir David,ILX ; Ottolenghi Michael,ILX ; Braun Sergei,ILX ; Zusman Rivka,ILX, Doped sol-gel glasses for obtaining chemical interactions.
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  12. Hubbell Jeffrey A. (Concord MA) Pathak Chandrashekhar P. (Austin TX) Sawhney Amarpreet S. (Newton MA) Desai Neil P. (Los Angeles CA) Hossainy Syed F. A. (Austin TX), Gels for encapsulation of biological materials.
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  13. Swain Philip A. ; Schad Victoria Carol ; Greenstein Julia Lea ; Exley Mark Adrian ; Fox Barbara Saxton ; Powers Stephen P. ; Gefter Malcolm L., Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation.
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  14. Harris Curtis C. ; Cole Katharine H. ; Lechner John F. ; Reddel Roger,AUX, Human liver epithelial cell lines.
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  15. Wedekind Frank,DEX ; Daser Adelheid,DEX ; Tischer Wilhelm,DEX, Immobilization of penicillin G amidase, glutaryl-7-ACA acylase or D-aminoacid oxidase on an aminofunctional organosilox.
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  16. Ducheyne Paul ; Radin Shulamith ; Santos Erick Manuel, Incorporation of biological molecules into bioactive glasses.
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  17. Easton Thomas G. (Coram NY) Reich Edward (Setauket NY), Injection/activation apparatus.
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  18. Dionne Keith E. ; Hegre Orion D. ; Flanagan Thomas R. ; Hazlett Tyrone F. ; Doherty Edward J., Inner supported biocompatible cell capsules.
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  21. Whitmire David R., Method for rapid enzymatic alcohol removal.
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  23. Naughton Brian A. ; Naughton Gail K., Methods of use of a three-dimensional liver cell and tissue culture system.
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  24. Lihme Allan Otto Fog,DKX ; B.o slashed.g-Hansen Thorkild Christian,DKX ; Nielsen Claus Schafer,DKX, Permeable hollow particles having an outer shell of mechanically rigid porous material.
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  25. Burke Philip John (Charlton GBX) Dowell Robert Ian (Congleton GBX) Mauger Anthony Brian (Kensington MD), Process for antibody directed enzyme prodrug therapy.
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  26. Frank Bruce H. (Indianapolis IN) Prouty Walker E. (Indianapolis IN) Heiney Richard E. (Greenwood IN) Walden Mark R. (Indianapolis IN), Process for transforming a human insulin precursor to human insulin.
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  27. Burke Philip J. (Charlton GBX) Dowell Robert I. (Congleton GBX) Mauger Anthony B. (Kensington MD) Springer Caroline J. (London GBX), Prodrugs for antibody directed enzyme prodrug therapy.
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  28. Avnir David (Jerusalem ILX) Ottolenghi Michael (Jerusalem ILX) Lev Ovadia (Jerusalem ILX), Qualitative and quantitative processes for reactive chemicals in liquids using doped sol-gel glasses.
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  29. Chari Ravi V. J. ; Goldmakher Viktor S. ; Blattler Walter A., Targeted delivery of cyclopropylbenzindole-containing cytotoxic drugs.
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  30. Blum Kenneth (San Antonio TX) Trachtenberg Michael C. (Houston TX), Treatment of cocaine addiction.
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