초록 ▼

Compositions and methods for the treatment of anorectal disorders are provided in which certain combinations of NO donors, PDE inhibitors, superoxide (O2-) scavengers, .beta.-adrenergic agonists, cAMP-dependent protein kinase activators, .alpha.1-adrenergic antagonists, L-type Ca2+ channel blockers,

Compositions and methods for the treatment of anorectal disorders are provided in which certain combinations of NO donors, PDE inhibitors, superoxide (O2-) scavengers, .beta.-adrenergic agonists, cAMP-dependent protein kinase activators, .alpha.1-adrenergic antagonists, L-type Ca2+ channel blockers, estrogens, ATP-sensitive K+ channel activators and smooth muscle relaxants are used.

대표청구항 ▼

1. A method of treating an anorectal disorder, and for controlling the pain associated therewith, the method comprising topically administering to the anorectal region of a subject in need of such treatment a therapeutically effective amount of a topical composition comprising an ATP-sensitive potas

1. A method of treating an anorectal disorder, and for controlling the pain associated therewith, the method comprising topically administering to the anorectal region of a subject in need of such treatment a therapeutically effective amount of a topical composition comprising an ATP-sensitive potassium channel opener in the amount of from about 0.01% to about 7.5%, wherein said therapeutically effective amount decreases hypertonicity of an anal sphincter muscle of the subject.