초록 ▼

Cell membrane maintenance of red blood cells and platelet concentrates is improved by the addition of 1 mM-10 mM L-carnitine and derivatives. This improvement allows extension of the period of viability of packed red blood cells and platelet concentrations beyond current periods. Additionally, the m

Cell membrane maintenance of red blood cells and platelet concentrates is improved by the addition of 1 mM-10 mM L-carnitine and derivatives. This improvement allows extension of the period of viability of packed red blood cells and platelet concentrations beyond current periods. Additionally, the materials so treated exhibit extended circulation half life upon transfusion to a patient. Improvements in membrane maintenance achieved by this method permit irradiation of sealed containers of blood products so as to substantially sterilize and destroy leukocytes in the same. Further, addition of L-carnitine or derivatives to plasma, red blood cells or platelet concentrates results in the suppression of bacrerial growth.

대표청구항 ▼

1. A method for suppressing bacterial growth in a blood fraction, comprising adding to a blood fraction a compound selected from the group consisting of L-carnitine, salts of L-carnitine, alkanoyl camitines, salts of alkanoyl camitinies, and mixtures thereof, in an amount effective to suppress bacte

1. A method for suppressing bacterial growth in a blood fraction, comprising adding to a blood fraction a compound selected from the group consisting of L-carnitine, salts of L-carnitine, alkanoyl camitines, salts of alkanoyl camitinies, and mixtures thereof, in an amount effective to suppress bacterial growth in said blood fraction,wherein said blood fraction is plasma, and wherein said method comprises adding said plasma to a support solution which comprises said compound.