초록 ▼

A crosslinkable macromer system and related methods of preparing the system and using the system in the form of a crosslinked matrix between a tissue site and an implant article such as a tissue implant or on the porous surface of a prosthetic device. The macromer system includes two or more polymer

A crosslinkable macromer system and related methods of preparing the system and using the system in the form of a crosslinked matrix between a tissue site and an implant article such as a tissue implant or on the porous surface of a prosthetic device. The macromer system includes two or more polymer-pendent polymerizable groups and one or more initiator groups (e.g., polymer-pendent initiator groups). The polymerizable groups and the initiator group(s), when polymer-pendent, can be pendent on the same or different polymeric backbones. The macromer system provides advantages over the use of polymerizable macromers and separate, low molecular weight initiators, including advantages with respect to such properties as nontoxicity, efficiency, and solubility. A macromer system of the invention can be used as an interface between the tissue site and implant article in a manner sufficient to permit tissue growth through the crosslinked matrix and between the tissue site and implant. In a preferred embodiment, polymers with pendent polymerizable groups, for use in the macromer system, are prepared by reacting a polysaccharide polymer with a reactive moiety in an organic, polar solvent such as formamide.

대표청구항 ▼

1. A method of delivering an implant article to a tissue site, the method comprisinga) providing an implant article selected from the group consisting of tissue implants and prosthetic devices providing a porous surface, b) providing a matrix-forming system comprising a polymerization initiator and

1. A method of delivering an implant article to a tissue site, the method comprisinga) providing an implant article selected from the group consisting of tissue implants and prosthetic devices providing a porous surface, b) providing a matrix-forming system comprising a polymerization initiator and a crosslinkable macromer comprising one or more polymers having pendent polymerizable groups, c) implanting the article within the tissue site with the matrix-forming system positioned between the article and the tissue site, and d) polymerizing the matrix-forming system to form a crosslinked matrix between the article and the tissue site suitable to permit continuous tissue growth through the matrix and between the implant article and the tissue site.