초록 ▼

The present invention provides an antiproliferative compound having the structural formula [EQU1]wherein X is oxygen, nitrogen or sulfur; R1 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxylic acid, carboxylate, carboxamide, ester, thioamide, thiolacid, thiolester, saccharide, alkoxy-linked sac

The present invention provides an antiproliferative compound having the structural formula [EQU1]wherein X is oxygen, nitrogen or sulfur; R1 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxylic acid, carboxylate, carboxamide, ester, thioamide, thiolacid, thiolester, saccharide, alkoxy-linked saccharide, amine, sulfonate, sulfate, phosphate, alcohol, ethers and nitriles; R2 is hydrogen, methyl, benzyl carboxylic acid, benzyl carboxylate, benzyl carboxamide, benzylester, saccharide and amine; R3 is selected from the group consisting of hydrogen, methyl, benzyl carboxylic acid, benzyl carboxylate, benzyl carboxamide, benzylester, saccharide and amine; R4 is of methyl, benzyl carboxylic acid, benzyl carboxylate, benzyl carboxamide, benzylester, saccharide and amine; and R5 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxyl, amide and ester. Also provided is a method for inducing apoptosis in a cell comprising administering a composition comprising a compound.

대표청구항 ▼

1. A compound having a structural formula [EQU33]wherein X is oxygen; wherein R1 is -C1-10 alkylene-COOH -C1-4 alkylene-CONH2, -C1-4 alkylene-COO-C1-4 alkyl, -C1-4 alkylene-CON(C1-4 alkylene-COOH)2, C1-4 alkylene-OH, C1-4 alkylene-NH3-halo, or C1-4 alkylene-OSO2NH(C1-4 alkyl)3; R2, R3 are H or C1-4

1. A compound having a structural formula [EQU33]wherein X is oxygen; wherein R1 is -C1-10 alkylene-COOH -C1-4 alkylene-CONH2, -C1-4 alkylene-COO-C1-4 alkyl, -C1-4 alkylene-CON(C1-4 alkylene-COOH)2, C1-4 alkylene-OH, C1-4 alkylene-NH3-halo, or C1-4 alkylene-OSO2NH(C1-4 alkyl)3; R2, R3 are H or C1-4 alkyl; R4 is C1-4 alkyl; and R5 is C7-16 alkyl, COOH, C7-16 olefinic group containing 3 to 5 ethylenic bonds, -C.dbd.C-COO-C1-4 alkyl or C1-4 alkylene-COO-C1-4 alkyl; with the proviso that R1 can not be -C2-4 alkylene-COOH nor C2 alkylene-OH when R2, R3, R4 are each methyl and R5 is a C16 alkyl.