초록

.alpha.- and .beta.-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.

대표청구항 ▼

3)2, -CONHCH3, -CONH(CH3)2, -CH2SO2NH2, -CH2CH2SO2NH2, -CH2S[O]CH3, -CH2S[O]2CH3, -C(CH3) 2(SCH3), -C(CH3)2(S[O]CH3), -C(CH3)2(S[O]2CH3), alkyl, hydroxyalkyl, cyanoalkyl, haloalkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, alkylthioalkyl, aralkyl, heteroaralkyl, aminoalkyl or mono- or disubsti

3)2, -CONHCH3, -CONH(CH3)2, -CH2SO2NH2, -CH2CH2SO2NH2, -CH2S[O]CH3, -CH2S[O]2CH3, -C(CH3) 2(SCH3), -C(CH3)2(S[O]CH3), -C(CH3)2(S[O]2CH3), alkyl, hydroxyalkyl, cyanoalkyl, haloalkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, alkylthioalkyl, aralkyl, heteroaralkyl, aminoalkyl or mono- or disubstituted aminoalkyl radical, wherein said substituents are selected from the group consisting of alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, heterocycloalkyl and heterocycloalkylalkyl radicals; or where said aminoalkyl radical is disubstituted, said substituents along with the nitrogen atom to which they are attached, form a heterocycloalkyl or a heteroaryl radical; and each of R1' and R1′ are independently a radical as defined for R1; or one of R1' and R1′ together with R1 and the carbon atoms to which R1, R1' and R1′ are attached, form a cycloalkyl radical.