초록 ▼

Cytotoxic T lymphocyte responses are effectively induced to an antigen of interest, particularly viral, bacterial, parasitic and tumor antigens. Compositions, including pharmaceutical compositions, of CTL-inducing peptide and an adjuvant or a lipidated peptide which induces a helper T cell (HTL) res

Cytotoxic T lymphocyte responses are effectively induced to an antigen of interest, particularly viral, bacterial, parasitic and tumor antigens. Compositions, including pharmaceutical compositions, of CTL-inducing peptide and an adjuvant or a lipidated peptide which induces a helper T cell (HTL) response stimulate the antigen specific CTL response. Among the viral antigens to which the CTL responses are effectively induced in humans are those of hepatitis B. The CTL response may be optimized by a regimen of two or more booster administrations. Cocktails of two or more CTL inducing peptides are employed to optimize epitope and/or MHC class I restricted coverage.

대표청구항 ▼

1. An immunogenically effective composition comprising:(i) a first peptide comprising an epitope, wherein the first peptide binds to an HLA class I molecule to form an epitope-HLA complex recognized by a human cytotoxic T cell wherein the said epitope recognized by a human cytotoxic T cell is a hepa

1. An immunogenically effective composition comprising:(i) a first peptide comprising an epitope, wherein the first peptide binds to an HLA class I molecule to form an epitope-HLA complex recognized by a human cytotoxic T cell wherein the said epitope recognized by a human cytotoxic T cell is a hepatitis B virus epitope, a hepatitis C virus epitope, a human immunodeficiency virus epitope, or a human papilloma virus epitope; (ii) a second peptide comprising an epitope, wherein the second peptide binds to an HLA class II molecule to form an epitope-HLA complex recognized by a human helper T cell; (iii) an adjuvant; and (iv) a physiologically acceptable carrier.