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Method of treating atherosclerosis or restenosis using microtubule stabilizing agent 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-033/08
  • A61K-031/337
출원번호 US-0821906 (1997-03-21)
발명자 / 주소
  • James L. Kinsella
  • Steven J. Sollot
출원인 / 주소
  • The United States of America as represented by the Secretary of the Department of Health and Human Services
대리인 / 주소
    Klarquist Sparkman, LLP
인용정보 피인용 횟수 : 61  인용 특허 : 15

초록 ▼

The present invention is a method of preventing or reducing atherosclerosis or restenosis, and a pharmaceutical preparation used therefor. In particular, it is a method of preventing or reducing atherosclerosis or restenosis after arterial injury by treatment with a low dose of a microtubule stabili

대표청구항

1. A method of inhibiting vascular restenosis in a subject following a procedure to restore patency of a blood vessel in the subject, comprising administering to the subject a therapeutically effective amount of deuterium oxide prior to or following the procedure.

이 특허에 인용된 특허 (15)

  1. Hunter William L.,CAX ; Machan Lindsay S.,CAX ; Arsenault A. Larry,CAX, Anti-angiogenic compositions and methods of use.
    상세보기
  2. Hunter William L.,CAX ; Machan Lindsay S.,CAX ; Arsenault A. Larry,CAX, Anti-angiogenic compositions and methods of use.
    상세보기
  3. Kopia Gregory A. (Phoenixville PA) Horan Paul K. (Downingtown PA) Gray Brian D. (Ardmore PA) Troutner David E. (Phoenixville PA) Muirhead Katharine A. (West Chester PA) Sheth Kamleshkumar A. (Downing, Compounds, compositions and methods for binding bio-affecting substances to surface membranes of bio-particles.
    상세보기
  4. Gunasekera Malika (Vero Beach FL) Gunasekera Sarath P. (Vero Beach FL) Longley Ross E. (Vero Beach FL) Burres Neal S. (Highland Park IL), Discodermolide compounds, compositions containing same and method of preparation and use.
    상세보기
  5. Gunasekera Malika (Vero Beach FL) Gunasekera Sarath P. (Vero Beach FL) Longley Ross E. (Vero Beach FL) Burres Neal S. (Highland Park IL), Discodermolide compounds, compositions containing same and methods of preparation and use.
    상세보기
  6. Trojanowski John Q. (Philadelphia PA) Lee Virginia M-Y. (Philadelphia PA), Method of stabilizing microtubules.
    상세보기
  7. Kinsella James L. (Baltimore MD) Sollott Steven J. (Baltimore MD), Method of treating atherosclerosis or restenosis using microtubule stabilizing agent.
    상세보기
  8. Haugwitz Rudiger D. (Bethesda MD) Zalkow Leon (Atlanta GA) Glinski Jan (Ridgefield CT) Suffness Mathew (Silver Spring MD) Deutsch Howard M. (Atlanta GA) Narayanan Venkatachala (Gaithersburg MD), Method of treating cancers sensitive to treatment with water soluble derivatives of taxol.
    상세보기
  9. Liepins Andrejs (331 Hamilton Avenue St. John\s ; Newfoundland CAX A1B 3V6), Methods and composition for the treatment of hypertension.
    상세보기
  10. Grainger David J.,GB2 ; Metcalfe James C.,GB2 ; Kunz Lawrence L. ; Schroff Robert W. ; Weissberg Peter L.,GB2, Prevention and treatment of cardiovascular pathologies.
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  11. Grainger David J.,GBX ; Metcalfe James C.,GBX ; Kunz Lawrence L. ; Schroff Robert W. ; Weissberg Peter L.,GBX, Prevention and treatment of cardiovascular pathologies.
    상세보기
  12. Kunz Lawrence L., Therapeutic inhibitor of vascular smooth muscle cells.
    상세보기
  13. Kunz Lawrence L. ; Klein Richard A. ; Reno John M., Therapeutic inhibitor of vascular smooth muscle cells.
    상세보기
  14. Kunz Lawrence L. ; Klein Richard A. ; Reno John M. ; Grainger David J.,GB2 ; Metcalfe James C.,GB2 ; Weissberg Peter L.,GB2 ; Anderson Peter G., Therapeutic inhibitor of vascular smooth muscle cells.
    상세보기
  15. Kunz Lawrence L. ; Klein Richard A. ; Reno John M. ; Grainger David J.,GBX ; Metcalfe James C.,GBX ; Weissberg Peter L.,GBX ; Anderson Peter G., Therapeutic inhibitor of vascular smooth muscle cells.
    상세보기

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  3. Lentz, David Christian; Llanos, Gerard H.; Roller, Mark B.; Scopelianos, Angelo; Weadock, Kevin, Coated medical devices.
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  4. Palasis, Maria; You, Changcheng; Concagh, Daniel; Core, Lee; Ho, Kirchel; Sharma, Upma; Zugates, Gregory T., Drug eluting medical implant.
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  6. Shanley, John F., Expandable medical device for delivery of beneficial agent.
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  9. Shanley, John F.; Eigler, Neal L.; Park, Kinam; Edelman, Elazer R., Expandable medical device for delivery of beneficial agent.
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  59. Kunz, Lawrence L.; Anderson, Peter G., Therapeutic inhibitor of vascular smooth muscle cells.
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  60. Kunz, Lawrence L.; Anderson, Peter G., Therapeutic inhibitor of vascular smooth muscle cells.
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