초록 ▼

Bioadhesive formulations to deliver, for both local and systemic effects, a wide variety of drugs of varying degrees of solubility are described. These formulations can be gels or aerosols and comprise a water-insoluble, pharmaceutically acceptable alkyl cellulose, a solvent system comprising a vola

Bioadhesive formulations to deliver, for both local and systemic effects, a wide variety of drugs of varying degrees of solubility are described. These formulations can be gels or aerosols and comprise a water-insoluble, pharmaceutically acceptable alkyl cellulose, a solvent system comprising a volatile solvent and water, a solubilizing agent or a dispersing agent, or a mixture thereof, and a pharmaceutical. These formulations can be made bioerodible and release the pharmaceutical in a controlled manner. Formulations further comprising a propellant such as 1,1-difluoroethane are also provided. The delivery can be made to a skin surface or to a mucosal surface. Methods for preparing and administering these formulations are also provided. Several specific examples using the anti-ulcer medication 2-amino-7-(1-methylethyl)-5-oxo-5H-[1]benzopyrano-[2,3-b]-pyridine-3-carboxylic acid are provided.

대표청구항 ▼

1. A non-water soluble, film-forming bioadhesive pharmaceutical gel comprising:a water-insoluble alkyl cellulose from about 0.1% to about 20% by weight of the gel; a solvent system comprising a mixture of from about 30% to about 90% by weight of at least one volatile solvent and from about 10% to ab

1. A non-water soluble, film-forming bioadhesive pharmaceutical gel comprising:a water-insoluble alkyl cellulose from about 0.1% to about 20% by weight of the gel; a solvent system comprising a mixture of from about 30% to about 90% by weight of at least one volatile solvent and from about 10% to about 25% by weight of water; a solubilization agent or a dispersing agent or a mixture thereof, wherein said solubilization agent or said dispersing agent is not polyactylic acid; and a pharmaceutical.