초록 ▼

A pharmaceutical composition for the controlled release of therapeutic agents from carboxylic acid ortho ester polymers contains a pharmaceutically acceptable salt of an acid, which together with the acid R1-COOH liberated from the decomposition of the ortho ester polymer forms a buffer system in a

A pharmaceutical composition for the controlled release of therapeutic agents from carboxylic acid ortho ester polymers contains a pharmaceutically acceptable salt of an acid, which together with the acid R1-COOH liberated from the decomposition of the ortho ester polymer forms a buffer system in a physiologically acceptable pH range.

대표청구항 ▼

1. A pharmaceutical composition for the controlled release of therapeutic agents from a polymer matrix comprising:a) the therapeutic agent or a combination of therapeutic agents to be administered; b) a bioerodible carboxylic acid ortho ester polymer consisting essentially of monomer repeating units

1. A pharmaceutical composition for the controlled release of therapeutic agents from a polymer matrix comprising:a) the therapeutic agent or a combination of therapeutic agents to be administered; b) a bioerodible carboxylic acid ortho ester polymer consisting essentially of monomer repeating units of the partial formula: [EQU18] wherein R1 represents hydrogen or C1-4-alkyl and A represents a hydrocarbon chain of the formula [EQU19]wherein Ra, Rb, and Rc independently represent hydrogen or C1-4-alkyl, and m and n independently represent zero or integers from one to three; c) a pharmaceutically acceptable salt of an acid, which together with the acid R1-COOH being liberated from the decomposition of the ortho ester polymer (I) forms a buffer system in a physiologically acceptable pH range; and the following optional components; d) further pharmaceutically acceptable additives; and or e) a pharmaceutically acceptable carrier liquid.