초록 ▼

The present invention provides medical devices such as medication infusion pumps having internal surfaces that are treated to inhibit protein denaturation. In accordance with the invention, hydrophilic internal surfaces and related coating methods are provided to reduce or eliminate accumulation of

The present invention provides medical devices such as medication infusion pumps having internal surfaces that are treated to inhibit protein denaturation. In accordance with the invention, hydrophilic internal surfaces and related coating methods are provided to reduce or eliminate accumulation of medication deposits which can otherwise occur when handling complex protein-based medications. Preferred hydrophilic pump surfaces include hydrophilic surfactants (PEO) or (PEG) coatings which exhibit very low protein adsorption characteristics. Several methods are disclosed for producing such treated surfaces including the covalent attachment of hydrophilic surfactants.

대표청구항 ▼

1. A medical device comprising a surface having a polypropylene glycol/polyethylene glycol polymer covalently attached thereto, wherein the polypropylene glycol/polyethylene glycol polymer has a molecular weight of about 1800 Daltons and comprises a compound of the following general formula: [EQU5]a

1. A medical device comprising a surface having a polypropylene glycol/polyethylene glycol polymer covalently attached thereto, wherein the polypropylene glycol/polyethylene glycol polymer has a molecular weight of about 1800 Daltons and comprises a compound of the following general formula: [EQU5]and wherein the surface having the polypropylene glycol/polyethylene glycol polymer covalently attached thereto defines a surface contact angle less than about 45 degrees and exhibits an insulin adsorption profile of less than about 1.0 microgram per square centimeter.