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Amorphous porous particles for deep lung delivery

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-009/12
출원번호 US-0888781 (2001-06-25)
발명자 / 주소
  • David A. Edwards
  • Giovanni Caponetti
  • Jeffrey S. Hrkach
  • Noah Lotan IL
  • Justin Hanes
  • Robert S. Langer
  • Abdellaziz Ben-Jebria
출원인 / 주소
  • The Penn State Research Foundation
  • Massachusetts Institute of Technology
대리인 / 주소
    Hamilton, Brook, Smith & Reynolds, P.C.
인용정보 피인용 횟수 : 14  인용 특허 : 35

초록

Improved porous particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the porous particles are made of a biodegradable material and have a mass density less than 0.4 g/cm3/. The particles may be formed of biod

대표청구항

1. An essentially dry composition comprising:amorphous biodegradable particles for delivering a therapeutic, prophylactic or diagnostic agent to the deep lung, wherein the particles have a mass density less than 0.4 g/cm3, a mass mean diameter between 5 .mu.m and 30 .mu.m and an aerodynamic diameter

이 특허에 인용된 특허 (35)

  1. Edwards David A. ; Caponetti Giovanni,ITX ; Hrkach Jeffrey S. ; Lotan Noah,ILX ; Hanes Justin ; Ben-Jebria Abdell Aziz ; Langer Robert S., Aerodynamically light particles for pulmonary drug delivery.
  2. Edwards David A. ; Caponetti Giovanni,ITX ; Hrkach Jeffrey S. ; Lotan Noah,ILX ; Hanes Justin ; Ben-Jebria Abdell Aziz ; Langer Robert S., Aerodynamically light particles for pulmonary drug delivery.
  3. DeLuca Patrick P. (Lexington KY) Rypacek Frantisek (Leckova CSX), Biodegradable microspheres as a carrier for macromolecules.
  4. Bell John H. (Loughborough GB2), Composition for treating airway disease.
  5. Baichwal Anand (Wappingers Falls NY) Staniforth John N. (Bath GB2), Controlled release insufflation carrier for medicaments.
  6. Illum Lisbeth (Charlottenlund DKX), Drug delivery system.
  7. Illum Lisbeth (Nottingham GBX), Enhanced uptake drug delivery system having microspheres containing an active drug and a bioavailability improving mater.
  8. Hughes O. Richard (Chatham NJ) Kurschus Dieter (Ocean County NJ), Highly porous compressible polymeric powders.
  9. Boardman Terence D. (Davenham GB2) Forrester Raymond B. (Sandbach GB2), Inhalation pharmaceuticals.
  10. Forrester Raymond B. (Sandbach GB2) Boardman Terence D. (Northwich GB2), Inhalation pharmaceuticals.
  11. Yen Richard C. K. (4261 Chase Ave. Los Angeles CA 90066), Manufacturing protein microspheres.
  12. Eljamal Mohammed ; Patton John S., Method and apparatus for pulmonary administration of dry powder alpha 1-antitrypsin.
  13. Hanna Mazen,GB3 ; York Peter,GB3, Method and apparatus for the formation of particles.
  14. Hanna Mazen,GBX ; York Peter,GBX, Method and apparatus for the formation of particles.
  15. Patton John S. (San Carlos CA) Platz Robert M. (Half Moon Bay CA), Method and device for delivering aerosolized medicaments.
  16. Wise Donald L. (Belmont MA) Trantolo Debra J. (Princeton MA) Gresser Joseph D. (Brookline MA), Method for making a bioerodible material for the sustained release of a medicament and the material made from the method.
  17. Castro Anthony J. (Chicago IL) Frank Dieter (Naperville IL) Madlock ; Jr. Cleve (Westmont IL), Method for making porous structures.
  18. Jaffe Howard (Gaithersburg MD), Microencapsulation process.
  19. Hanes Justin ; Edwards David A. ; Evora Carmen,ESX ; Langer Robert, Particles incorporating surfactants for pulmonary drug delivery.
  20. Boyes Robert N. (St. Albans AL GB2) Tice Thomas R. (Birmingham AL) Gilley Richard M. (Birmingham AL) Pledger Kenneth L. (Huntsville AL), Pharmaceutical formulations comprising microcapsules.
  21. Domb Abraham J. (Brookline MA) Langer Robert S. (Somerville MA), Polyanhydrides with improved hydrolytic degradation properties.
  22. DeLuca Patrick P. (Lexington KY) Kanke Motoko (Fukuyama JPX) Sato Toyomi (Tokyo CA JPX) Schroeder Hans G. (Encinitas CA), Porous microspheres for drug delivery and methods for making same.
  23. Edwards David A. ; Caponetti Giovanni ; Hrkach Jeffrey S. ; Lotan Noah,ILX ; Hanes Justin ; Langer Robert S. ; Ben-Jebria Abdellaziz, Porous particles for deep lung delivery.
  24. De Luca Patrick P. (Lexington KY) Rypacek Frantisek (Leckova CZX), Preparation of biodegradable microspheres useful as carriers for macromolecules.
  25. Edwards David A. ; Langer Robert S. ; Vanbever Rita ; Mintzes Jeffrey ; Wang Jue ; Chen Donghao, Preparation of particles for inhalation.
  26. Ek Bo R. (Stockholm SEX) Eriksson Kjell G. (Spnga SEX) Nyqvist Per Gustaf H. (Tullinge SEX) Ragnarsson Gert A. (Bro SEX), Process for the manufacture of porous cellulose matrices.
  27. York Peter,GB3 ; Hanna Mazen,GBX, Salmeterol xinafoate with controlled particle size.
  28. Illum Lisbeth,GB2, Small particle compositions for intranasal drug delivery.
  29. Illum Lisbeth,GB2, Small particle compositions for intranasal drug delivery.
  30. Liversidge Gary G. (West Chester PA) Cundy Kenneth C. (Pottstown PA) Bishop John F. (Rochester NY) Czekai David A. (Honeoye Falls NY), Surface modified drug nanoparticles.
  31. Leong Helen (Atherton CA) Katz Martin (Menlo Park CA) Delk Ann (Kensington CA) Nacht Sergio (Los Altos CA) Berliner David (Atherton CA), Synthetic melanin aggregates.
  32. Andersson Jan (Sodra Sandby SEX) Jagfeldt Hans (Lund SEX) Trofast Eva (Lund SEX) Wetterlin Kjell (Sodra Sandby SEX), System for dispensing pharmaceutically active compounds.
  33. Backstrom Kjell Goran Erik,SEX ; Dahlback Carl Magnus Olof,SEX ; Edman Peter,SEX ; Johansson Ann Charlotte Birgit,SEX, Systemic administration of a therapeutic preparation.
  34. Bckstrm Kjell G. E. (Lund SEX) Dahlbck Carl M. O. (Lund SEX) Edman Peter (Bjrred SEX) Johansson Ann C. B. (Lund SEX), Systemic administration of a therapeutic preparation.
  35. Bckstrm Kjell G. E. (Lund SEX) Dahlbck Carl M. O. (Lund SEX) Edman Peter (Bjrred SEX) Johansson Ann C. B. (Lund SEX), Therapeutic preparation for inhalation.

이 특허를 인용한 특허 (14)

  1. Lipp, Michael M.; Sung, Jean C., Cationic dry powders.
  2. Lipp, Michael M.; Sung, Jean C., Cationic dry powders.
  3. Lipp, Michael M.; Sung, Jean C., Dry powder formulations and methods for treating pulmonary diseases.
  4. Lipp, Michael M.; Sung, Jean C.; Clarke, Robert W.; Hava, David L., Dry powder formulations and methods for treating pulmonary diseases.
  5. Kim, Kyekyoon; Singh, Ravindra Pratap, Electrohydrodynamic spraying system.
  6. Edwards, David A.; Batvcky, Richard P.; Johnston, Lloyd, Highly efficient delivery of a large therapeutic mass aerosol.
  7. Kim, Kyekyoon; Choi, Hyungsoo; Choy, Young Bin, Microparticles.
  8. Kim,Kyekyoon; Choi,Hyungsoo; Choy,Young Bin, Microparticles.
  9. Lipp, Michael M.; Sung, Jean C., Monovalent metal cation dry powders for inhalation.
  10. Hwang, Robin; Sullivan, Vincent; Huang, Juan; Wang, Zhaolin; Mikszta, John A.; Montgomery, David; Ford, Brandi; Bhuta-Wills, Anjana, Pharmaceutical compositions in particulate form.
  11. Lipp, Michael M.; Kamerkar, Abhijit, Rapamycin powders for pulmonary delivery.
  12. Lipp, Michael M.; Sung, Jean C., Respirably dry powder comprising calcium lactate, sodium chloride and leucine.
  13. Sung, Jean C.; Manzanedo, Diana; Perry, Jason M.; Dehaan, Wesley; Trautman, Brian, Tiotropium dry powders.
  14. Lipp, Michael M.; Batycky, Richard P., Ultra low density pulmonary powders.
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