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Sustained release hydrophobic bioactive PLGA microspheres 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61F-013/00
  • A61F-002/00
  • A61K-009/32
  • A61K-009/22
출원번호 US-0920326 (1997-08-21)
발명자 / 주소
  • Noelle Christine Vook
  • Elliott Jacob
  • Jean A. Setterstrom
  • John van Hamont
  • William Vaughan
  • Ha Duong
출원인 / 주소
  • The United States of America as represented by the Secretary of the Army
대리인 / 주소
    Elizabeth Arwine
인용정보 피인용 횟수 : 52  인용 특허 : 43

초록

A controlled release microcapsulate pharmaceutical formulation for burst-free, sustained, programmable release of hydrophocib bioactive agent over a duration from 24 hours to 100 days comprising: and a blend of end-capped uncapped biocompatible, biodegradable poly(lactide/glycolide).

대표청구항

1. A controlled release microcapsule pharmaceutical composition of burst-free, sustained, programmable release of a hydrophobic bioactive agent over a duration of 24 hours to 100 days, comprising a hydrophobic bioactive agent and a blend of end-capped and uncapped biocompatible, biodegradable poly(l

이 특허에 인용된 특허 (43)

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  • Bodmer David (Klingnau CHX) Fong Jones W. (Parsippany NJ) Kissel Thomas (Staufen DEX) Maulding Hawkins V. (Mendham NJ) Nagele Oskar (Sissach CHX) Pearson Jane E. (Ogendensburg NJ), Sustained release formulations of water soluble peptides.
  • Reid Robert H. (Kensington MD) Boedeker Edgar C. (Chevy Chase MD) van Hamont John E. (Shape MD BEX) Setterstrom Jean A. (Takoma Park MD), Vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompa.
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    5. Smith, Craig A.; Wiley, Steven; Kaykas, Ajamete; Probst, Peter, CD47 related compositions and methods for treating immunological diseases and disorders.
    6. Bar, Eli; Holzer, Zeev Asher; Paz, Ofir, Carotid stent apparatus and methods for treatment via body lumens.
    7. Jadhav, Vasant R., Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference.
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    10. Chen, Lishan; Cui, Kunyuan; Chen, Yuching; Mayer, Sasha J.; Houston, Jr., Michael E., Compositions and methods for enhancing delivery of nucleic acids into cells and for modifying expression of target genes in cells.
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    52. Seo, Min-Hyo; Kim, Bong-Oh; Choi, In-Ja; Shim, Myung-Seob, pH responsive biodegradable polylactic acid derivatives forming polymeric micelles and uses thereof for poorly water soluble drug delivery.
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