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Chitosan-based nitric oxide donor compositions 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61L-015/00
  • A61F-013/00
  • A61K-009/00
  • C08B-037/08
출원번호 US-0576096 (2000-05-22)
발명자 / 주소
  • Daniel J. Smith
  • Sibel Yazici TR
출원인 / 주소
  • The University of Akron
대리인 / 주소
    Renner, Kenner, Greive, Bobak, Taylor & Weber
인용정보 피인용 횟수 : 102  인용 특허 : 24

초록

A chitosan-based polymeric nitric oxide donor composition comprising a modified chitosan polymer and a nitric oxide [N2O2] dimer, wherein the nitric oxide [N2O2] dimer is bonded directly to the backbone of the modified chitosan polymer without further binding through a nucleophile residue or moiety.

대표청구항

1. A nitric oxide donor composition containing a chitosan polymer having nitric oxide (N2O2-) groups bonded thereto, said composition having the general formula: [EQU16]wherein R1 is an organic group having from 5 to about 18 carbon atoms; wherein x is from about 0.5 to about 0.8; wherein y is from

이 특허에 인용된 특허 (24)

  1. Keefer Larry K. (Bethesda MD) Wink David A. (Frederick MD) Dunams Tambra M. (Frederick MD) Hrabie Joseph A. (Frederick MD), Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof.
  2. Keefer Larry K. (Bethesda MD) Wink David A. (Hagerstown MD) Dunams Tambra M. (Florence AL) Hrabie Joseph A. (Frederick MD), Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof.
  3. Keefer Larry K. (Bethesda MD) Wink David A. (Frederick MD) Dunams Tambra M. (Frederick MD) Hrabie Joseph A. (Frederick MD), Antihypertensive compositions and use thereof.
  4. Smith Daniel J. ; Serhatkulu Sibel, Chitosan-based nitric oxide donor compositions.
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  15. Keefer Larry K. (Bethesda MD) Dunams Tambra M. (Florence AL) Saavedra Joseph E. (Thurmont MD), Oxygen substituted derivatives of nucleophile-nitric oxide adducts as nitric oxide donor prodrugs.
  16. Conboy James J. (Ithaca NY) Hotchkiss Joseph H. (Ithaca NY), Photolytic interface for HPLC-chemiluminescence detection of non volatile N-nitroso compounds.
  17. Keefer Larry K. (Bethesda MD) Hrabie Joseph A. (Frederick MD), Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biologic.
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  21. Grinstead Robert R. (Walnut Creek CA), Process for the removal of NO from fluid streams using a water-soluble polymeric chelate of a polyvalent metal.
  22. Ohta Tomohisa (Tochigi JPX) Hagiwara Hiroyuki (Shimodate JPX) Kanbara Hisashige (Shimodate JPX) Dobashi Akihiko (Shimodate JPX) Seki Yasuyuki (Hitachi JPX), Radiation curable pressure sensitive adhesive composition.
  23. Keefer Larry K. (Bethesda MD), Stabilized nitric oxide - primary amine complexes useful as cardiovascular agents.
  24. Muzzarelli Riccardo (Ancona ITX), Substituted and crosslinked glucans, process and intermediates for preparing them and use thereof.

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