초록 ▼

This invention provides microfabricated systems for extraction of desired particles from a sample stream containing desired and undesired particles. The sample stream is placed in laminar flow contact with an extraction stream under conditions in which inertial effects are negligible. The contact be

This invention provides microfabricated systems for extraction of desired particles from a sample stream containing desired and undesired particles. The sample stream is placed in laminar flow contact with an extraction stream under conditions in which inertial effects are negligible. The contact between the two streams is maintained for a sufficient period of time to allow differential transport of the desired particles from the sample stream into the extraction stream. In a preferred embodiment the differential transport mechanism is diffusion. The extraction system of this invention coupled to a microfabricated diffusion-based mixing device and/or sensing means allows picoliter quantities of fluid to be processed or analyzed on devices no larger than silicon wafers. Such diffusion-based mixing or sensing devices are preferably channel cell systems for detecting the presence and/or measuring the quantity of analyte particles in a sample stream.

대표청구항 ▼

1. A microfluidic system comprising:(a) a plurality of inlets; (b) a microfluidic flow channel in fluid communication with said inlets; (c) at least two outlets in fluid communication with said microfluidic flow channel; and (d) flow control means connected to all but one of said inlets and said out

1. A microfluidic system comprising:(a) a plurality of inlets; (b) a microfluidic flow channel in fluid communication with said inlets; (c) at least two outlets in fluid communication with said microfluidic flow channel; and (d) flow control means connected to all but one of said inlets and said outlets.