초록 ▼

Crosslinkable compositions are provided that readily crosslink in situ to provide biocompatible, nonimmunogenic crosslinked biomaterials. The compositions contain at least three biocompatible, nonimmunogenic components having reactive functional groups thereon, with the functional groups selected so

Crosslinkable compositions are provided that readily crosslink in situ to provide biocompatible, nonimmunogenic crosslinked biomaterials. The compositions contain at least three biocompatible, nonimmunogenic components having reactive functional groups thereon, with the functional groups selected so as to enable inter-reaction between the components, i.e., crosslinking. In a preferred embodiment, a first component is polynucleophilic, a second component is polyelectrophilic, and at least one third component contains one or more functional groups reactive with the nucleophilic moieties one the first or second component. At least one of the components is a polyfunctional hydrophilic polymer; the other components may also comprise hydrophilic polymers, or they may be low molecular weight, typically hydrophobic, crosslinkers. Methods for preparing and using the compositions are also provided. Exemplary uses include tissue augmentation, biologically active agent delivery, bioadhesion, and prevention of adhesions following surgery or injury.

대표청구항 ▼

1. A crosslinkable system comprisingat least three biocompatible, reactive compounds each comprised of a molecular core having at least one functional group attached thereto through a direct covalent bond or through a linking group, wherein under reaction-enabling conditions each reactive compound i

1. A crosslinkable system comprisingat least three biocompatible, reactive compounds each comprised of a molecular core having at least one functional group attached thereto through a direct covalent bond or through a linking group, wherein under reaction-enabling conditions each reactive compound is capable of substantially immediate covalent reaction with at least one other of the plurality of reactive compounds by virtue of the at least one functional group, and further wherein: each molecular core is selected from the group consisting of synthetic hydrophilic polymers, naturally occurring hydrophilic polymers, hydrophobic polymers, and C2-C14 hydrocarbyl groups containing zero to 2 heteroatoms selected from N, O, S and combinations thereof; at least one of the molecular cores is a synthetic hydrophilic polymer; and at least two of the molecular cores contain at least two functional groups.