IPC분류정보
국가/구분 |
United States(US) Patent
등록
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국제특허분류(IPC7판) |
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출원번호 |
US-0510537
(2000-02-22)
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발명자
/ 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 |
피인용 횟수 :
102 인용 특허 :
4 |
초록
▼
A method and apparatus for delivery of genes, enzymes and biological agents to tissue cells, including a method and apparatus wherein treatment fluids, including genes, enzymes and biological agents, are injected into a target area of a body providing selective attachment to the specific target cell
A method and apparatus for delivery of genes, enzymes and biological agents to tissue cells, including a method and apparatus wherein treatment fluids, including genes, enzymes and biological agents, are injected into a target area of a body providing selective attachment to the specific target cells without affecting normal tissue cells. The method is used to treat prostate cancer, breast cancer, uterine cancer, bladder cancer, stomach, lung, colon, and brain cancer, etc. A hollow core needle is inserted into a body, the needle being visually guided by a selected imaging technique. A first embodiment utilizes an endoscopic instrument, wherein a probe is inserted into the body, guided by the endoscope to the vicinity of the target area. The hollow core needle is guided to the vicinity by a channel through the probe. A needle adjustment apparatus is used to extend or retract the needle and adjust needle tip orientation toward a target area. The endoscope provides a view to an operator for adjustment of the apparatus to extend the tip of the needle into and through tissue, interstitially, to a target area for deposit of the specific treatment fluid. A non-invasive imaging technique is used either alone, or in addition to the endoscope, to give an operator a view of the needle for guiding the needle tip to the precise target area. Typical non-invasive techniques include CT scan, MRI, ultrasound, etc.
대표청구항
▼
1. A method for treating a localized portion of body tissue comprising:(a) inserting a needle apparatus in a body, said apparatus including at least one hollow core needle for delivering treatment fluid into said body wherein said needle apparatus further includes a sheath having a lumen of greater
1. A method for treating a localized portion of body tissue comprising:(a) inserting a needle apparatus in a body, said apparatus including at least one hollow core needle for delivering treatment fluid into said body wherein said needle apparatus further includes a sheath having a lumen of greater diameter than an outer diameter of said needle for providing a gap between said needle and said sheath, and said needle extending through said lumen, and said sheath having an evacuation port through a wall of said heath and said evacuation port having fluid communication with a suction connector for connection to a vacuum to extract fluid from said body through said gap; (b) guiding said needle apparatus to a target tissue in need of treatment, and said guiding including use of an imaging technique for viewing inside an area of tissue without physically invading said area; and (c) applying said treatment fluid to said target tissue through said needle apparatus; wherein said treatment fluid is selected from the group consisting of genes, viruses, proteins, inhibitors, tissue markers, bioabsorbable polymers and other biological agents and chemotherapeutic agents.
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