초록 ▼

Bone augmentation in a mammalian body to enhance the mechanical strength of a prosthesis is provided by reinforcement of bone in the region surrounding the implant device. A number of fibrillar wires are formed on the prosthetic implant device. Formation of the fibrillar wires comprises gauging the

Bone augmentation in a mammalian body to enhance the mechanical strength of a prosthesis is provided by reinforcement of bone in the region surrounding the implant device. A number of fibrillar wires are formed on the prosthetic implant device. Formation of the fibrillar wires comprises gauging the implant device so that the fibrillar wires are formed by peeling them from the implant device. Alternatively, formation of the fibrillar wires may comprise forming a mesh of fibrillar wires having a woolly structure, forming the mesh around the prosthetic implant device, and attaching a number of the fibrillar wires to the prosthetic implant device. A coating is formed on the fibrillar wires and an associated prosthetic implant device. The coating comprises bone morphogenetic proteins along with osteoinductive factors and osteoconductive factors that function as nutrients, anti-microbial and anti-inflammatory agents, and blood-clotting factors. The polymer is a polymer matrix component comprising lactic acid, glycolic acid, and copolymers of lactic acid and glycolic acid. The osteoinductive coating combined with the fibrillar wool or prongs should allow for optimal osteointegration and physiologic load distribution of a implant device resulting in prosthetic success when placed in the human body.

대표청구항 ▼

1. A mesh for bone augmentation comprising at least one fibrillar wire arranged in a woolly structure, the at least one fibrillar wire having an oxide layer, the mesh comprising a coating on and between the at least one fibrillar wire, wherein the coating comprises a carrier-polymer and osteoinducti

1. A mesh for bone augmentation comprising at least one fibrillar wire arranged in a woolly structure, the at least one fibrillar wire having an oxide layer, the mesh comprising a coating on and between the at least one fibrillar wire, wherein the coating comprises a carrier-polymer and osteoinductive and osteoconductive proteins, wherein osteointegration is promoted into the woolly structure when the mesh is placed in a mammalian bone.