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Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-035/14
출원번호 US-0525428 (1990-05-16)
발명자 / 주소
  • Edward A. Boyse
  • Hal E. Broxmeyer
  • Gordon W. Douglas
출원인 / 주소
  • PharmaStem Therapeutics, Inc.
대리인 / 주소
    Pennie & Edmonds LLP
인용정보 피인용 횟수 : 68  인용 특허 : 6

초록 ▼

The present invention relates to hematopoietic stem and progenitor cells of neonatal or fetal blood that are cryopreserved, and the therapeutic uses of such stem and progenitor cells upon thawing. In particular, the present invention relates to the therapeutic use of fetal or neonatal stem cells for

대표청구항 ▼

1. A cryopreserved pharmaceutical composition comprising:(a) viable human neonatal or fetal hematopoietic stem cells derived from the umbilical cord blood or placental blood of a single human collected at the birth of said human, in which said cells are present in an amount sufficient to effect hema

이 특허에 인용된 특허 (6)

  1. Junnila Matti A. J. (Helsinki FIX), Cryoprotectant solution and method.
    상세보기
  2. Boyse Edward A. (Tucson AZ) Broxmeyer Hal E. (Indianapolis IN) Douglas Gordon W. (New York NY), Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood and methods of the.
    상세보기
  3. Senkan Selim M. (Oak Ridge TN) Hirsch Gerald P. (Oak Ridge TN), Method of freezing living cells and tissues with improved subsequent survival.
    상세보기
  4. Boyse Edward A. (New York NY) Broxmeyer Hal E. (Indianapolis IN) Douglas Gordon W. (New York NY), Preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood.
    상세보기
  5. Sato Toru (2560 Hatagasaki ; Yonago-shi ; Tottori-ken JPX) Okazaki Naoto (Yonago JPX) Hiyoshi Katsumi (Hamada JPX), Preserving solution for blood or packed blood cells and method for preserving blood or packed blood cells by using the s.
    상세보기
  6. Rowe Arthur W. (Stamford CT) Dayian George (Albany NY), Process for freezing blood platelets.
    상세보기

이 특허를 인용한 특허 (68)

  1. Abbot, Stewart; Edinger, James W.; Francki, Aleksandar; Kaplunovsky, Aleksandr; Jankovic, Vladimir; Labazzo, Kristen; Law, Eric; Padliya, Neerav D.; Paredes, Jennifer; Wang, Jia-Lun, Amnion derived adherent cells.
    상세보기
  2. Abbot, Stewart; Edinger, James W.; Francki, Aleksandar; Kaplunovsky, Aleksandr; Jankovic, Vladimir; Labazzo, Kristen; Law, Eric; Padliya, Neerav; Paredes, Jennifer; Wang, Jia-Lun, Amnion derived adherent cells.
    상세보기
  3. Abbot, Stewart; Edinger, James W.; Francki, Aleksandar; Hariri, Robert J.; Jankovic, Vladimir; Kaplunovsky, Aleksandr; Labazzo, Kristen; Law, Eric; Padliya, Neerav D.; Paredes, Jennifer; Wang, Jia-Lun, Angiogenesis using placental stem cells.
    상세보기
  4. Altobelli, David E., Apparatus for stem cell collection and methods thereof.
    상세보기
  5. Zeitlin, Andy; Russotti, Gregory; He, Shuyang; Pal, Ajai; Chen, Hong J.; Brieva, Thomas; Shorr, Ryan; Murphy, Brian, Cell composition and methods of making the same.
    상세보기
  6. Laughlin,Mary J.; Haynesworth,Stephen; Pompili,Vincent, Cell-based therapies for ischemia.
    상세보기
  7. Heidaran, Mohammad; Wang, Jia-Lun; Ye, Qian; Zeitlin, Andrew; Delaney, Colleen Suzanne, Co-culture of placental stem cells and stem cells from a second source.
    상세보기
  8. Heidaran, Mohammad; Wang, Jia-Lun; Ye, Qian; Zeitlin, Andrew; Dulaney, Colleen Suzanne, Co-culture of placental stem cells and stem cells from a second source.
    상세보기
  9. Hariri, Robert J., Cytotherapeutics, cytotherapeutic units and methods for treatments using them.
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  10. McKenna, Jr., David H.; Tigges, Barbara M.; Berger, Michael J., Differentiation of multi-lineage progenitor cells to respiratory epithelial cells.
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  11. Hariri,Robert J., Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells.
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  12. Abbot, Stewart; Karasiewicz-Mendez, Kathy E.; Voskinarian-Berse, Vanessa; Zhang, Xiaokui, Enhancement of placental stem cell potency using modulatory RNA molecules.
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  13. Rubinstein,Pablo; Coelho,Philip Henry; Stevens,Cladd E., High concentration white blood cells as a therapeutic product.
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  14. Paludan, Casper; Edinger, James W.; Harbacheuski, Ryhor; Murray, RoseAnn; Hariri, Robert J., Immunomodulation using placental stem cells.
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  15. Paludan, Casper; Edinger, James; Harbacheuski, Ryhor; Murray, RoseAnn; Hariri, Robert J., Immunomodulation using placental stem cells.
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  16. Paludan, Casper; Edinger, James; Harbacheuski, Ryhor; Murray, RoseAnn; Hariri, Robert J., Immunomodulation using placental stem cells.
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  17. Hariri, Robert J., Isolated placental perfusate and placental cells isolated therefrom.
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  18. Michejda, Maria, Isolation and preservation of fetal hematopoietic and mesencymal system cells from non-controversial materials and/or tissues resulting from miscarriages and methods of therapeutic use.
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  19. Gage, Frederick A., Method for isolation of afterbirth derived cells.
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  20. Hariri, Robert J., Method of collecting placental stem cells.
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  21. Hariri,Robert J., Method of collecting placental stem cells.
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  22. Kuypers, Frans A.; Serikov, Vladimir B., Method of isolating stem and progenitor cells from placenta.
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  23. Heidaran, Mohammad A.; Zhang, Xiaokui; Kang, Lin; Zeitlin, Andrew; Voskinarian-Berse, Vanessa R.; Abbott, Stewart Ernest, Method of producing erythrocytes.
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  24. Abbot, Stewart; Kang, Lin; Voskinarian-Berse, Vanessa; Zhang, Xiaokui, Method of producing erythrocytes without feeder cells.
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  25. Abbot, Stewart; Kang, Lin; Voskinarian-Berse, Vanessa; Zhang, Xiaokui, Method of producing erythrocytes without feeder cells.
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  26. Hariri, Robert J., Method of propagating cells.
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  27. Chow, Robert, Method of treating a hematopoietic associated disease or disorder with plasma-depleted, but not erythrocyte-depleted cord blood compositions.
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  28. Chang, Yun Sil; Park, Won Soon; Yang, Yoon-Sun, Method of treating lung diseases using cells separated or proliferated from umbilical cord blood.
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  29. Abramson, Sascha D.; Guelakis, Marian; Heidaran, Mohammad A.; Labazzo, Kristen; Yaccoby, Shmuel, Methods and compositions for treatment of bone defects with placental cell populations.
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  30. Lemischka, Ihor R.; Moore, Kateri; Pereira, Carlos Filipe, Methods for programming differentiated cells into hematopoietic stem cells.
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  31. Hariri, Robert J.; Heidaran, Mohammad A.; Jasko, Stephen; Kang, Lin; Law, Eric; Pal, Ajai; Stout, Bhavani; Voskinarian-Berse, Vanessa; Zeitlin, Andrew; Zhang, Xiaokui, Methods of generating natural killer cells.
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  32. Hariri, Robert J.; Heidaran, Mohammad A.; Jasko, Stephen; Kang, Lin; Law, Eric; Pal, Ajai; Stout, Bhavani; Voskinarian-Berse, Vanessa; Zeitlin, Andrew; Zhang, Xiaokui, Methods of generating natural killer cells.
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  33. Atala, Anthony; De Coppi, Paolo, Methods of isolation, expansion and differentiation of fetal stem cells from chorionic villus, amniotic fluid, and placenta and therapeutic uses thereof.
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  34. Atala, Anthony; De Coppi, Paolo, Methods of isolation, expansion and differentiation of fetal stem cells from chorionic villus, amniotic fluid, and placenta and therapeutic uses thereof.
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  35. Collins, Daniel P.; Sprague, Stacey L.; Tigges, Barbara M., Multi-lineage progenitor cells.
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  36. Collins, Daniel P.; Sprague, Stacey L.; Tigges, Barbara M., Multi-lineage progenitor cells.
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  37. Collins, Daniel P.; Sprague, Stacey L.; Tigges, Barbara M., Multi-lineage progenitor cells.
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  38. Crawford, Keith D.; Southgate, Christopher, Multipotent stem cells and uses thereof.
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  39. Zhang, Xiaokui; Hariri, Robert J.; Voskinarian-Berse, Vanessa; Kang, Lin; Law, Eric; Abbot, Stewart, Natural killer cells from placenta.
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  40. Edinger, James; Ye, Qian; Wang, Jai-Lun; Hariri, Robert J., Placental stem cell populations.
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  44. Hariri, Robert J., Placental stem cell populations.
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  45. Hariri,Robert J., Placental stem cells.
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  46. Hariri, Robert J., Placental stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells.
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  47. Chow, Robert, Plasma-depleted, not erythrocyte-depleted, cord blood compositions and method of making.
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  48. Hariri,Robert J., Post-partum mammalian placenta, its use and placental stem cells therefrom.
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  49. Gage, Fred, Pulsatile perfusion extraction method for non-embryonic pluripotent stem cells.
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  50. Hariri, Robert J., Renovation and repopulation of decellularized tissues and cadaveric organs by stem cells.
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  51. Johnson, Lanny L., Synovial villi for use with tissue engineering.
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  52. Hariri, Robert J.; Gurney, Jodi P., Treatment of amyotrophic lateral sclerosis using placental stem cells.
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  53. Zhang, Xiaokui; Yaccoby, Shmuel; Abramson, Sascha; Hariri, Robert J., Treatment of bone-related cancers using placental stem cells.
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  54. Hariri, Robert J., Treatment of diseases or disorders using placental stem cells.
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  55. Edinger, James W.; Hariri, Robert J.; Wang, Jia-Lun; Ye, Qian; Faleck, Herbert, Treatment of inflammatory diseases using placental stem cells.
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  56. Edinger, James W.; Hariri, Robert J.; Wang, Jia-Lun; Ye, Qian; Faleck, Herbert, Treatment of inflammatory diseases using placental stem cells.
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  57. Paludan, Casper; Edinger, James W.; Harbacheuski, Ryhor; Murray, RoseAnn; Hariri, Robert J., Treatment of multiple sclerosis using placental stem cells.
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  58. Hariri, Robert J., Treatment of organ injuries and burns using placental stem cells.
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  59. Herzberg, Uri; Gurney, Jodi P., Treatment of pain using placental stem cells.
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  60. Edinger, James W.; Hariri, Robert J.; Wang, Jia-Lun; Ye, Qian; Faleck, Herbert, Treatment of psoriasis using placental stem cells.
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  61. Hariri, Robert J., Treatment of radiation injury using placental stem cells.
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  62. Edinger, James W.; Fischkoff, Steven Alan; Francki, Aleksandar; Jankovic, Vladimir; Liang, Bitao; Martin, Philippe; Ray, Cynthia; Zhang, Xiaokui, Treatment of sarcoidosis using placental stem cells.
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  63. Zeitlin, Andy; Pal, Ajai, Treatment of stroke using isolated placental cells.
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  64. Hariri, Robert J., Treatment of stroke using placental stem cells.
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  65. Hariri, Robert J.; Heidaran, Mohammad A.; Kang, Lin; Padliya, Neerav Dilip; Pal, Ajai; Voskinarian-Berse, Vanessa; Zeitlin, Andrew; Zhang, Xiaokui, Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells.
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  66. Hariri, Robert J.; Heidaran, Mohammad A.; Kang, Lin; Padliya, Neerav Dilip; Pal, Ajai; Voskinarian-Berse, Vanessa; Zeitlin, Andrew; Zhang, Xiaokui, Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells.
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  67. Johnson, Lanny, Use of autologous sediment from fluid aspirates as vehicles for drug delivery.
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  68. Johnson, Lanny L., Use of synovium and omentum for tissue engineering.
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