초록 ▼

Microdialysis device (10), comprising at least a probe (1) provided with an inlet (2) and an outlet (3) for bringing a perfusion fluid into contact with a bodily fluid in a part of a living organism and causing constituents from this fluid to be taken up by this perfusion fluid, whereby the perfusio

Microdialysis device (10), comprising at least a probe (1) provided with an inlet (2) and an outlet (3) for bringing a perfusion fluid into contact with a bodily fluid in a part of a living organism and causing constituents from this fluid to be taken up by this perfusion fluid, whereby the perfusion fluid is enriched to dialysate, wherein the outlet (3) is integrally received in a silicon chip (5) and debouches in a first fluid channel (6) formed in this silicon chip (5) and wherein further at least one analysis means, for instance an ISFET (17, 18), for analysing constituents of the bodily fluid taken up by the perfusion fluid is integrally received in the silicon chip (5) in a manner such that dialysate flowing from the outlet (3) comes into contact with said analysis means in the first fluid channel (6), and wherein the silicon chip (5) is further optionally provided with pumping means (50) or dosing means.

대표청구항 ▼

1. Microdialysis device (10, 20), comprising at least a probe (1) provided With an inlet (2) and an outlet (3) for bringing a perfusion fluid into contact with a bodily fluid in a part of a living organism and causing constituents from this fluid to be taken up by this perfusion fluid, whereby the p

1. Microdialysis device (10, 20), comprising at least a probe (1) provided With an inlet (2) and an outlet (3) for bringing a perfusion fluid into contact with a bodily fluid in a part of a living organism and causing constituents from this fluid to be taken up by this perfusion fluid, whereby the perfusion fluid is enriched to dialysate, further comprising analysis means (7, 8, 9, 11) for analysing constituents of the bodily fluid taken up by the perfusion fluid, wherein the outlet (3) of the probe (1) is integrally received in a silicon chip (5) and debouches in a first fluid channel (6) formed in this silicon chip (5), and at least one analysis means comprising a fluid reservoir (7, 8, 9, 44) is integrally received in the silicon chip (5) in a manner such that dialysate flowing from the outlet (3) comes into contact with said analysis means in the first fluid channel (6), the silicon chip (5) being provided with pumping means (50) for pumping the perfusion fluid respectively the dialysate, characterized in that the pumping means (50) comprise at least one closed reservoir which is filled with a reversibly expandable medium and is provided with an actuator for the expansion of this medium, which reservoir is closed on one side by a movable wall part.