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Microencapsulation and sustained release of biologically active acid-stable or free sulfhydryl-containing proteins 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A01N-037/18
출원번호 US-0501934 (2000-02-10)
발명자 / 주소
  • Mark A. Tracy
  • Kevin L. Ward
  • David S. Scher
  • J. Keith Johnson
출원인 / 주소
  • Alkermes Controlled Therapeutics, Inc.
대리인 / 주소
    Hamilton, Brook, Smith and Reynolds, P.C.
인용정보 피인용 횟수 : 34  인용 특허 : 22

초록 ▼

This invention relates to sustained release compositions, and methods of forming and using said compositions, for the sustained release of biologically active acid-stable or free sulfhydryl-containing proteins, in particular .beta.-IFN. The sustained release composition of this invention comprises a

대표청구항 ▼

1. A solid composition for the sustained release of biologically active acid-stable or free sulfhydryl-containing protein comprising:a) a biocompatible polymer; b) particles of a stabilized biologically active acid-stable or free sulfhydryl-containing protein formulation comprising at least one biol

이 특허에 인용된 특허 (22)

  1. Leong Kam W. (Ellicott City MD), Biocompatible and biodegradable poly (phosphoester-urethanes).
    상세보기
  2. Eury Robert P. (Half Moon Bay CA) Patel Rajesh (San Mateo CA), Blocked polymeric particles having internal pore networks for delivering active substances to selected environments.
    상세보기
  3. Tracy Mark A. ; Bernstein Howard ; Khan M. Amin, Composition and method for the controlled release of metal cation-stabilized interferon.
    상세보기
  4. Hutchinson Francis G. (Lymm GBX), Continuous release pharmaceutical compositions.
    상세보기
  5. Eppstein Deborah A. (Palo Alto CA) Schryver Brian B. (Redwood City CA), Controlled release of macromolecular polypeptides.
    상세보기
  6. Hanisch Wolfgang H. (Oakland CA) Fernandes Peter M. (Walnut Creek CA) Taforo Terrance (Oakland CA), Formulation for lipophilic IL-2 proteins.
    상세보기
  7. Hanisch Wolfgang H. (Balmoral Heights AUX) Fernandes Pete M. (Walnut Creek CA) Taforo Terrance (Oakland CA) Thomson James W. (Albany CA), Formulation processes for lipophilic proteins.
    상세보기
  8. Yim Zachary (Paramus NJ) Zupon Martin (Basking Ridge NJ) Chaudry Imtiaz (Denville NJ), Insoluble copper-alpha interferon complex.
    상세보기
  9. Grossberg Sidney E. (Whitefish Bay Milwaukee WI) Sedmak Joseph J. (Milwaukee WI), Interferon stabilization.
    상세보기
  10. Hershenson Susan (San Francisco CA) Thomson Jody (Albany CA), Low pH pharmaceutical compositions of recombinant b 상세보기
  • Igari Yasutaka (Hyogo JPX) Saikawa Akira (Osaka JPX) Okamoto Kayoko (Osaka JPX) Kamei Shigeru (Hyogo JPX) Oka Masahisa (Kanagawa JPX) Sano Atsunori (Saitama JPX), Matrix for sustained-release preparation.
    상세보기
  • Reichert Paul (Montville NJ) McNemar Charles (Basking Ridge NJ) Nagabhushan Nagamani (Parsippany NJ) Nagabhushan Tattanahalli L. (Parsippany NJ) Tindall Stephen (Madison NJ) Hruza Alan (Hackettstown , Metal-interferon-alpha crystals.
    상세보기
  • Tice Thomas R. (Helena AL) Lewis Danny H. (Gardendale AL), Microencapsulation process.
    상세보기
  • Bernstein Howard (Cambridge MA) Zhang Yan (Cambridge MA) Khan M. Amin (Downingtown PA) Tracy Mark A. (Arlington MA), Modulated release from biocompatible polymers.
    상세보기
  • DeLuca Patrick P. (Lexington KY) Kanke Motoko (Fukuyama JPX) Sato Toyomi (Tokyo CA JPX) Schroeder Hans G. (Encinitas CA), Porous microspheres for drug delivery and methods for making same.
    상세보기
  • Hanisch Wolfgang H. (Oakland CA) Fernandes Peter M. (Lafayette CA), Process for the recovery of human b 상세보기
  • Herbert Paul F. ; Healy Michael S., Production scale method of forming microparticles.
    상세보기
  • Okada Hiroaki (Osaka JPX) Ogawa Yasuaki (Osaka JPX) Yashiki Takatsuka (Hyogo JPX), Prolonged release microcapsules and their production.
    상세보기
  • Silvestri Loui J. (Miramar FL) Pyle H. Ruth (Ft. Lauderdale FL), Sustained release dosage form.
    상세보기
  • Martin Alain, Therapeutic permeation enhanced-wound healing compositions and methods for preparing and using same.
    상세보기
  • Gombotz Wayne R. (Lexington MA) Healy Michael S. (E. Bridgewater MA) Brown Larry R. (Newton MA), Very low temperature casting of controlled release microspheres.
    상세보기
  • Yim, Zachary; Zupon, Michael A.; Chaudry, Imtiaz A., Zinc-protamine-alpha interferon complex.
    상세보기

    • 이 특허를 인용한 특허 (34)

    1. Garidel, Patrick; Henderson, Isaac Craig; Klein, Pamela, Antibody formulations and methods.
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    2. Garidel, Patrick; Henderson, Isaac Craig; Klein, Pamela, Antibody formulations and methods for treating AL amyloidosis.
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    3. Bechet, Anne Chantal; Van Dijkhuizen-Radersma, Riemke; Stigter, Martin; Bezemer, Jeroen Mattijs, Controlled release compositions for interferon based PEGT/PBT block copolymers and method for preparation thereof.
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    4. Bechet, Anne Chantal; Van Dijkhuizen-Radersma, Riemke; Stigter, Martin; Bezemer, Jeroen Mattijs, Controlled release compositions for interferon based on PEGT/PBT block copolymers and method for preparation thereof.
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    5. Spencer, Jr., David Gelvin; Humphries, John Elliott; De Leede, Leonardus Gerardus Jozef; Verrijk, Rudolf, Controlled release interferon drug products and treatment of HCV infections using same.
      상세보기
    6. Shirley,Bret A.; Babuka,Susan; Chen,Bao Lu; Hora,Maninder; Choe,Minna; Tellers,Melanie, HSA-free formulations of interferon-β.
      상세보기
    7. Shirley, Bret A; Babuka, Susan; Chen, Bao-Lu; Hora, Maninder; Choe, Minna; Tellers, Melanie, HSA-free formulations of interferon-Beta.
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    8. Shirley, Bret A.; Babuka, Susan; Chen, Bao-Lu; Hora, Maninder; Choe, Minna; Tellers, Melanie, HSA-free formulations of interferon-beta.
      상세보기
    9. Shirley, Bret A; Babuka, Susan; Chen, Bao-Lu; Hora, Maninder; Choe, Minna; Tellers, Melanie, HSA-free formulations of interferon-β.
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    10. Irache Garreta, Juan Manuel; De La Rasilla, Carlos Gamazo; Larruga, Maria Luisa Sanz; Puga, Marta Ferrer; Aberasturi, Beatriz San Román; Salman, Hesham H. A.; Martinez, Sara Gómez; Rep{dot over (a)}raz, Javier Ochoa, Immune response stimulating composition comprising nanoparticles based on a methyl vinyl ether-maleic acid copolymer.
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    11. Steiner, Solomon S.; Pohl, Roderike; Li, Ming; Hauser, Robert, Insulin formulations for rapid uptake.
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    12. Costantino, Henry R.; Hotz, Joyce M.; Dasch, James R.; Riley, M. Gary I.; Burke, Paul A.; Steitz-Abadi, Susan A.; Zale, Stephen E., Microencapsulation and sustained release of biologically active polypeptides.
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    13. Costantino,Henry R.; Hotz,Joyce M., Microencapsulation and sustained release of biologically active polypeptides.
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    14. Costantino,Henry R.; Hotz,Joyce M.; Bobka,Edward W., Microencapsulation and sustained release of biologically active polypeptides.
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    15. Garreta, Juan Manuel Irache; Yoncheva, Krassimira Pavlova, Pegylated nanoparticles.
      상세보기
    16. Wright, Steven G.; Christensen, Troy; Yeoh, Thean; Rickey, Michael E.; Hotz, Joyce M.; Kumar, Rajesh; Costantino, Henry R.; Smith, Christine; Lokensgard, David M.; Fineman, Mark; Ong, John, Poly(lactide-co-glycolide) based sustained release microcapsules comprising a polypeptide and a sugar.
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    17. Wright, Steven G.; Christensen, Troy; Yeoh, Thean; Rickey, Michael E.; Hotz, Joyce M.; Kumar, Rajesh; Costantino, Henry R., Polymer-based sustained release device.
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    18. Wright, Steven G.; Christensen, Troy; Yeoh, Thean; Rickey, Michael E.; Hotz, Joyce M.; Kumar, Rajesh; Costantino, Henry R., Polymer-based sustained release device.
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    19. Wright, Steven G.; Christensen, Troy; Yeoh, Thean; Rickey, Michael E.; Hotz, Joyce M.; Kumar, Rajesh; Costantino, Henry R., Polymer-based sustained release device.
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    20. Wright, Steven G.; Christensen, Troy; Yeoh, Thean; Rickey, Michael E.; Hotz, Joyce M.; Kumar, Rajesh; Costantino, Henry R., Polymer-based sustained release device.
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    21. Wright, Steven G.; Christensen, Troy; Yeoh, Thean; Rickey, Michael E.; Hotz, Joyce M.; Kumar, Rajesh; Costantino, Henry R., Polymer-based sustained release device.
      상세보기
    22. Wright, Steven G.; Christensen, Troy; Yeoh, Thean; Rickey, Michael E.; Hotz, Joyce M.; Kumar, Rajesh; Fineman, Mark; Smith, Christine; Ong, John; Lokensgard, David M.; Costantino, Henry R., Polymer-based sustained release device.
      상세보기
    23. Wright, Steven G.; Christensen, Troy; Yeoh, Thean; Rickey, Michael E.; Hotz, Joyce M.; Kumar, Rajesh; Fineman, Mark; Smith, Christine; Ong, John; Lokensgard, David; Costantino, Henry R., Polymer-based sustained release device.
      상세보기
    24. Wright,Steven G.; Christenson,Troy; Yeah,Thean Y.; Rickey,Michael E.; Hotz,Joyce M.; Kumar,Rajesh; Costantino,Henry R., Polymer-based sustained release device.
      상세보기
    25. Steiner, Solomon S.; Pohl, Roderike, Rapid acting and long acting insulin combination formulations.
      상세보기
    26. Steiner, Solomon S.; Pohl, Roderike, Rapid acting and long acting insulin combination formulations.
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    27. Pohl, Roderike; Steiner, Solomon S., Rapid acting injectable insulin compositions.
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    28. Rickey, Michael E.; Ramstack, J. Michael; Kumar, Rajesh, Residual solvent extraction method and microparticles produced thereby.
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    29. Rickey, Michael E.; Ramstack, J. Michael; Kumar, Rajesh, Residual solvent extraction method and microparticles produced thereby.
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    30. Rickey, Michael E.; Ramstack, J. Michael; Kumar, Rajesh, Residual solvent extraction method and microparticles produced thereby.
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    31. Steiner, Solomon S.; Brown, Craig; Pohl, Roderike; Poole, Trent; Steiner, Erik, Sublingual drug delivery device.
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    32. Hunt, Terrence J., Sustained release poloxamer containing pharmaceutical compositions.
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    33. Hunt, Terrence J., Sustained release poloxamer containing pharmaceutical compositions.
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    34. Hunt, Terrence J., Sustained release poloxamer containing pharmaceutical compositions.
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