초록 ▼

Disclosed is an osteogenic device capable of inducing the formation of endochondral bone in a shape conforming substantially to the shape of the device when implanted in a mammalian host. The device includes an osteogenic protein dispersed within a porous matrix comprising a polymer of collagen and

Disclosed is an osteogenic device capable of inducing the formation of endochondral bone in a shape conforming substantially to the shape of the device when implanted in a mammalian host. The device includes an osteogenic protein dispersed within a porous matrix comprising a polymer of collagen and glycosaminoglycan cross-linked to an MC value of about 800 to about 60,000. Also disclosed are a method of inducing mammalian bone growth, and a method of inducing conductive bone growth from viable mammalian bone.

대표청구항 ▼

1. An osteogenic device for inducing local bone or cartilage formation in a mammal, said device comprising:(a) biocompatible, synthetic, porous matrix, said matrix comprising a polymer of collagen and glycosaminoglycan crosslinked ex vivo to an MC value of about 800 to about 60,000 and comprising gr

1. An osteogenic device for inducing local bone or cartilage formation in a mammal, said device comprising:(a) biocompatible, synthetic, porous matrix, said matrix comprising a polymer of collagen and glycosaminoglycan crosslinked ex vivo to an MC value of about 800 to about 60,000 and comprising greater than 1% by weight of said glycosaminoglycan; (b) osteogenic protein capable of inducing endochondral bone formation in a mammal dispersed within said matrix; and (c) solidifying agent.