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Methods for promoting growth of bone using ZVEGF4 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-038/18
  • A61K-009/14
  • C07K-014/00
  • C07K-017/00
출원번호 US-0540224 (2000-03-31)
발명자 / 주소
  • Debra G. Gilbertson
  • Charles E. Hart
출원인 / 주소
  • ZymoGenetics, Inc.
대리인 / 주소
    Gary E. Parker
인용정보 피인용 횟수 : 46  인용 특허 : 6

초록 ▼

Methods for promoting growth of bone, ligament, or cartilage in a mammal are disclosed. The methods comprise administering to said mammal a composition comprising a pharmacologically effective amount of zvegf4 in combination with a pharmaceutically acceptable delivery vehicle. Also disclosed are met

대표청구항 ▼

1. A method for promoting growth of bone, in a mammal comprising administering to said mammal a composition comprising a pharmacologically effective amount of a protein comprising a first polypeptide disulfide-bonded to a second polypeptide, wherein each of said first and second polypeptides compris

이 특허에 인용된 특허 (6)

  1. Moore Emma E. (Seattle WA), Compositions and methods for stimulating the growth of osteoblasts.
    상세보기
  2. Antoniades Harry N. (Newton MA) Lynch Samuel E. (Jamaica Plain MA), Method for periodontal regeneration.
    상세보기
  3. Walter Mary Ann ; Leatherbury Neil C. ; Niederauer Mark Q., Moldable, hand-shapable biodegradable implant material.
    상세보기
  4. Edwards Martin W. ; Larsen Niels Christian,DKX, Platelet derived growth factor gel formulation.
    상세보기
  5. Boyan Barbara D. ; Schwartz Zvi,ILX, Resurfacing cartilage defects with chondrocytes proliferated without differentiation using platelet-derived growth factor.
    상세보기
  6. Antoniades Harry N. (Newton MA) Lynch Samuel E. (Jamaica Plain MA), Wound headling composition of TGF-alpha and PDGF.
    상세보기

이 특허를 인용한 특허 (46)

  1. Corvalan,Jose R. F.; Jia,Xiao Chi; Feng,Xiao; Yang,Xiao dong; Chen,Francine; Gazit,Gadi; Weber,Richard; Bezabeh,Binyam, Antibodies directed to PDGFD and uses thereof.
    상세보기
  2. Behnam, Keyvan, Bone matrix compositions and methods.
    상세보기
  3. Behnam, Keyvan, Bone matrix compositions and methods.
    상세보기
  4. Behnam, Keyvan; Cioffi, Christopher, Bone matrix compositions and methods.
    상세보기
  5. Behnam, Keyvan; Cioffi, Christopher, Bone matrix compositions and methods.
    상세보기
  6. Behnam, Keyvan; Wei, Guobao; Forsyth, Nanette, Bone matrix compositions and methods.
    상세보기
  7. Behnam, Keyvan; Wei, Guobao; Forsyth, Nanette; Boyce, Todd M.; Shimp, Lawrence A., Bone matrix compositions and methods.
    상세보기
  8. Wei, Guobao; Behnam, Keyvan; Forsyth, Nanette, Bone matrix compositions having nanoscale textured surfaces.
    상세보기
  9. Wei, Guobao; Behnam, Keyvan; Forsyth, Nanette, Bone matrix compositions having nanoscale textured surfaces.
    상세보기
  10. Lynch, Samuel E.; Hart, Charles E., Compositions and methods for arthrodetic procedures.
    상세보기
  11. Hart, Charles E.; Topouzis, Stavros, Compositions and methods for improving kidney function.
    상세보기
  12. Hart, Charles E.; Hollinger, Jeffrey O.; Lynch, Samuel E., Compositions and methods for treating bone.
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  13. Hart, Charles E.; Hollinger, Jeffrey O.; Lynch, Samuel E., Compositions and methods for treating bone.
    상세보기
  14. Hart, Charles E.; Lynch, Samuel E.; Young, Conan; Nickols, Joshua, Compositions and methods for treating rotator cuff injuries.
    상세보기
  15. Hart, Charles E.; Lynch, Samuel E.; Young, Conan S.; Perrien, Dan, Compositions and methods for treating the vertebral column.
    상세보기
  16. Wei, Guobao; Behnam, Keyvan; Forsyth, Nanette; Winterbottom, John; Beisser, James; Boyce, Todd M., Delivery system.
    상세보기
  17. Wei, Guobao; Behnam, Keyvan; Forsyth, Nanette; Winterbottom, John; Beisser, James; Boyce, Todd M.; Berven, Sigurd H.; Betz, Randal R.; O'Brien, Michael F.; Shelokov, Alexis P., Delivery system.
    상세보기
  18. Wei, Guobao; Behnam, Keyvan; Forsyth, Nanette; Winterbottom, John; Beisser, James; Boyce, Todd M.; Attawia, Mohamed; Richards, Cristy J.; Shimp, Lawrence A., Delivery system attachment.
    상세보기
  19. Wei, Guobao; Behnam, Keyvan; Forsyth, Nanette; Winterbottom, John; Beisser, James; Boyce, Todd; Attawia, Mohamed; Richards, Cristy J.; Shimp, Lawrence A., Delivery system attachment.
    상세보기
  20. Wei, Guobao; Boyce, Todd M.; Shimp, Lawrence A., Delivery system cartridge.
    상세보기
  21. Betz, Randal R.; Boden, Scott; Gupta, Munish Chandra; O'Brien, Michael F.; Sandhu, Harvinder; Shelokov, Alexis; Sybert, Daryl R.; Vaccaro, Alexander; Wei, Guobao; Boyce, Todd M.; Cohen, Robert; Richards, Cristy; Shimp, Lawrence A., Delivery systems, tools, and methods of use.
    상세보기
  22. Behnam, Keyvan; Wei, Guobao; Beisser, James, Demineralized bone matrix compositions and methods.
    상세보기
  23. Behnam, Keyvan; Wei, Guobao; Beisser, James A., Demineralized bone matrix compositions and methods.
    상세보기
  24. Hubbell, Jeffrey A.; Schense, Jason C.; Sakiyama Elbert, Shelly E., Growth factor modified protein matrices for tissue engineering.
    상세보기
  25. Morris, John W.; Shimp, Lawrence A.; Kaes, David R., Implant retaining device.
    상세보기
  26. Morris, John W.; Shimp, Lawrence A.; Kaes, David R., Implant retaining device.
    상세보기
  27. Alfaro, Arthur A.; Shimp, Lawrence A.; Russell, James L.; Boyle, John W.; Martz, Erik O.; Rosenthal, Daniel E.; Morris, John W., Intervertebral implants.
    상세보기
  28. Petersen, Kenneth C.; Einhorn, Thomas; Reed, David L., Joint revision implant.
    상세보기
  29. Lynch, Samuel E.; Nevins, Myron; Simion, Massimo, Maxillofacial bone augmentation using rhPDGF-BB and a biocompatible matrix.
    상세보기
  30. Shimp, Lawrence A.; Wei, Guobao; Behnam, Keyvan, Method of treating bone tissue.
    상세보기
  31. Kadiyala, Sudhakar, Methods and kits for aseptic filing of products.
    상세보기
  32. Kadiyala, Sudhakar, Methods and kits for aseptic filling of products.
    상세보기
  33. Lynch, Samuel E.; Hart, Charles E.; Ehrlich, Michael G.; Moore, Douglas C., Methods for treatment of distraction osteogenesis using PDGF.
    상세보기
  34. Knaack, David; Diegmann, Michele; Manrique, Albert; Benham, Keyvan, Non-glycerol stabilized bone graft.
    상세보기
  35. Behnam, Keyvan; Forsyth, Nanette; Russell, James; Winterbottom, John; Boyce, Todd, Osteoinductive demineralized cancellous bone.
    상세보기
  36. Behnam, Keyvan; Forsyth, Nanette; Russell, James; Winterbottom, John; Boyce, Todd, Osteoinductive demineralized cancellous bone.
    상세보기
  37. Charier, Gaëlle; Müller-Maissen, Manuela; Jen, Anna, PDGF fusion proteins incorporated into fibrin foams.
    상세보기
  38. Lutolf, Matthias; Schense, Jason C.; Hubbell, Jeffrey A.; Jen, Anna, PTH containing cell growth matrix.
    상세보기
  39. Kestler, Hans K.; Shah, Vivek; Rager-Aguiar, Dean James, Platelet-derived growth factor compositions and methods for the treatment of tendinopathies.
    상세보기
  40. Lynch, Samuel E.; Wisner-Lynch, Leslie A.; Kestler, Hans K.; Liu, Yanchun, Platelet-derived growth factor compositions and methods for the treatment of tendon and ligament injuries.
    상세보기
  41. Lynch, Samuel E., Platelet-derived growth factor compositions and methods of use thereof.
    상세보기
  42. Lynch,Samuel E., Platelet-derived growth factor compositions and methods of use thereof.
    상세보기
  43. Shimp, Lawrence A.; Winterbottom, John M.; Kaes, David R.; Boyce, Todd M.; Martz, Erik O., Processes for making spinal intervertebral implant, interconnections for such implant.
    상세보기
  44. Wei, Guobao; Boyce, Todd M.; Cohen, Robert; Richards, Cristy; Shimp, Lawrence A., Segmented delivery system.
    상세보기
  45. Wei, Guobao; Boyce, Todd M.; Cohen, Robert; Richards, Cristy; Shimp, Lawrence A., Segmented delivery system.
    상세보기
  46. Schense, Jason; Watson, John; Arrighi, Isabelle, Supplemented matrices for the repair of bone fractures.
    상세보기

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