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Three-dimensional polymer matrices 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-009/14
출원번호 US-0463709 (2000-01-28)
국제출원번호 PCT/US98/16020 (1998-07-31)
§371/§102 date 20000929 (20000929)
국제공개번호 WO99/09149 (1999-02-25)
발명자 / 주소
  • Venkatram R. Shastri
  • Ivan Martin
  • Robert S. Langer
  • Joachim Seidel
출원인 / 주소
  • Massachusetts Institute of Technology
대리인 / 주소
    Clark & Elbing LLP
인용정보 피인용 횟수 : 149  인용 특허 : 37

초록

Matrices that include a macrostructure having a semi-solid network and voids, and a microstructure having voids, in which the microstructure is located within the semi-solid network are disclosed. Methods for preparing these matrices are also disclosed.

대표청구항

1. A matrix comprising a macrostructure having a substantially continuous semi-solid network and voids, said matrix further comprising a microstructure having voids, wherein said microstructure is located within said semi-solid network.

이 특허에 인용된 특허 (37)

  1. Brekke John H. (Duluth MN), Apparatus for biodegradable, osteogenic, bone graft substitute device.
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  2. Shikinami Yasuo,JPX, Biocompatible implant material comprising a tri-axial or more three-dimensional fabric.
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  3. Hubbell Jeffrey A. (Austin TX) Sawhney Amarpreet S. (Austin TX), Biocompatible microcapsules.
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  4. Hubbell Jeffrey A. (Austin TX) Sawhney Amarpreet S. (Austin TX), Biocompatible microcapsules.
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  5. Mikos Antonios G. (Houston TX) Sarakinos Georgios (Boston MA) Vacanti Joseph P. (Winchester MA) Langer Robert S. (Newton MA) Cima Linda G. (Lexington MA), Biocompatible polymer membranes and methods of preparation of three dimensional membrane structures.
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  6. Mikos Antonios G. (Houston TX), Biodegradable bone templates.
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  7. Daniels Alma U. (Salt Lake City UT) Heller Jorge (Woodside CA), Biodegradable composites for internal medical use.
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  8. Jefferies Steven R. (5802 Leith Walk Baltimore MD 21239), Bone graft material for osseous defects and method of making same.
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  9. Yannas Ioannis V. (Newton Center MA) Burke John F. (Belmont MA), Cell-seeding procedures involving fibrous lattices.
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  10. Shalaby Shalaby W. (Anderson SC) Roweton Susan L. (Clemson SC), Continuous open-cell polymeric foams containing living cells.
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  11. Laurencin Cato T. (Somerville MA) Lucas Paul A. (Macon GA) Syftestad Glenn T. (Sacramento CA) Domb Abraham (Baltimore MD) Glowacki Julianne (Jamaica Plan MA) Langer Robert S. (Newton MA), Delivery system for controlled release of bioactive factors.
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  12. Laurencin Cato T. (Somerville MA) Lucas Paul A. (Macon GA) Syftestad Glenn T. (Sacramento CA) Domb Abraham (Baltimore MD) Glowacki Julianne (Jamaica Plan MA) Langer Robert S. (Newton MA), Delivery system for controlled release of bioactive factors.
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  13. Laurencin Cato T. (Somerville MA) Lucas Paul A. (Macon GA) Syftestad Glenn T. (Sacramento CA) Domb Abraham (Baltimore MD) Glowacki Julie (Jamaica Plan MA) Langer Robert S. (Newton MA), Delivery system for controlled release of bioactive factors.
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  14. Brekke John H. (4921 Pike La. ; Rte. #1 Duluth MN 55811), Device and method for treating and healing a newly created bone void.
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  15. Hrkach Jeffrey S. (Somerville MA) Langer Robert S. (Newton MA) Lotan Noah (Haifa ILX), Functionalized polyester graft copolymers.
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  16. Hubbell Jeffrey A. (Austin TX) Pathak Chandrashekhar P. (Waltham MA) Sawhney Amarpreet S. (Newton MA) Desai Neil P. (Los Angeles CA) Hill-West Jennifer L. (Austin TX) Hossainy Syed F. A. (Austin TX), Gels for encapsulation of biological materials.
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  18. Brekke John H. (Duluth MN), Method and apparatus for diodegradable, osteogenic, bone graft substitute device.
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  19. Hubbell Jeffrey A. (Austin TX) Elbert Donald (Austin TX) Hill-West Jennifer L. (Austin TX) Drumbeller Paul D. (Austin TX) Chowdhury Sanghamitra (Round Rock TX) Sawhney Amarpreet (Newtown MA), Methods for modifying cell contact with a surface.
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  20. Seare ; Jr. William J. (3190 Chula Vista Cir. Salt Lake City UT 84121), Methods of making a porous device.
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  22. Lopatin George (Newton Centre MA) Yen Larry Y. (Tewksbury MA), Microporous membranes of ultrahigh molecular weight polyethylene.
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  23. Hubbell Jeffrey A. (Austin TX) Elbert Donald (Austin TX) Hill-West Jennifer L. (Austin TX) Drumheller Paul D. (Austin TX) Chowdhury Sanghamitra (Round Rock TX) Sawhney Amarpreet (Newton MA), Multifunctional organic polymers.
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  24. Lucas Paul A. (Macon GA) Young Henry E. (Macon GA) Laurenchin Cato T. (Somerville MA), Muscle morphogenic protein and use thereof.
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  25. Vacanti Joseph P. (Winchester MA) Vacanti Charles A. (Lexington MA) Langer Robert S. (Newton MA), Neomorphogenesis of cartilage in vivo from cell culture.
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  26. Hubbell Jeffrey A. (Austin TX) Pathak Chandrashekhar P. (Waltham MA) Sawhney Amarpreet S. (Newton MA) Desai Neil P. (Los Angeles CA) Hill Jennifer L. (Austin TX), Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers.
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  27. Hubbell Jeffrey A. (Austin TX) Pathak Chandrashekhar P. (Waltham MA) Sawhney Amarpreet S. (Newton MA) Desai Neil P. (Los Angeles CA) Hill-West Jennifer L. (Austin TX), Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers.
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  28. Laurencin Cato T. (Somerville MA) Devin Jessica (Sunnyvale CA) Attawia Muhammed (Watertown MA), Polymeric-hydroxyapatite bone composite.
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  29. Seare ; Jr. William J. (3190 Chula Vista Cir. Salt Lake City UT 84121), Porous material product and process.
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  30. Seita Yukio (Fuji JPX) Nagaki Shoichi (Fuji JPX) Tatebe Ken (Fuji JPX) Kido Kousuke (Fukuoka JPX), Porous polypropylene membrane and methods for production thereof.
    상세보기
  31. Seare ; Jr. William J. (3190 Chula Vista Cir. Salt Lake City UT 84121), Porous product mold form.
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  32. Charbonneau Larry F. (Mendham NJ) Gupta Balaram (N. Plainfield NJ) Linstid H. Clay (Clinton NJ) Sawyer Linda C. (Chatham NJ) Shepherd James P. (Springfield NJ), Process for forming improved liquid crystalline polymer blends.
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  33. Shinomura ; Toshihiko, Process for producing permeable membranes.
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  34. Guiseppi-Elie Anthony (1017 Randolph Dr. Yardley PA 19067), Surface functionalized and derivatized electroactive polymers with immobilized active moieties.
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  35. Jamison Warren E. (Edmonds WA) Stull Dean P. (Longmont CO) Guzzetta Franklin H. (Middletown OH), Thermoset microporous polymer lubricating composition and method for forming the same.
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  36. Naughton Gail K. (Groton VT) Naughton Brian A. (Groton VT), Three-dimensional cell and tissue culture system.
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  37. Cima Linda G. (Lexington MA) Cima Michael J. (Lexington MA), Tissue regeneration matrices by solid free form fabrication techniques.
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