초록 ▼

An implantable device having a body of matrix material made up of insoluble collagen fibrils, and disposed therewithin(a) a plurality of vertebrate cells; and(b) a plurality of microspheres each of which consists primarily of one or more of the following materials: collagen, polystyrene, dextran, po

An implantable device having a body of matrix material made up of insoluble collagen fibrils, and disposed therewithin(a) a plurality of vertebrate cells; and(b) a plurality of microspheres each of which consists primarily of one or more of the following materials: collagen, polystyrene, dextran, polyacrylamide, cellulose, calcium alginate, latex, polysulfone, or glass.

대표청구항 ▼

1. A method of producing a polypeptide in vitro, comprising:providing a composition comprising a body of matrix material comprising insoluble collagen fibrils, there being embedded within the body of matrix material (a) a plurality of cultured vertebrate cells which express the polypeptide and (b) a

1. A method of producing a polypeptide in vitro, comprising:providing a composition comprising a body of matrix material comprising insoluble collagen fibrils, there being embedded within the body of matrix material (a) a plurality of cultured vertebrate cells which express the polypeptide and (b) a plurality of microspheres; maintaining the composition under conditions whereby the cultured vertebrate cells express and secrete the polypeptide; contacting the composition with a liquid such that the cells secrete the polypeptide into the liquid; and obtaining the polypeptide from the liquid.