Indoline derivatives and method of treating obesity
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-031/40
C07D-209/82
출원번호
US-0977783
(2001-10-15)
우선권정보
EP-0122539 (2000-10-16)
발명자
/ 주소
Jonathan Mark Bentley GB
James Edward Paul Davidson GB
Howard Langham Mansell GB
Nathaniel Julius Thomas Monck GB
인용정보
피인용 횟수 :
5인용 특허 :
3
초록▼
The present invention relates to indoline derivatives. These compounds are especially useful for the prevention and treatment of disorders of the central nervous system; damage to the central nervous system; cardiovascular disorders; gastrointestinal disorders; diabetes, sleep apnea, and especially
The present invention relates to indoline derivatives. These compounds are especially useful for the prevention and treatment of disorders of the central nervous system; damage to the central nervous system; cardiovascular disorders; gastrointestinal disorders; diabetes, sleep apnea, and especially for the treatment and prevention of obesity.
대표청구항▼
1. A compound selected from the group consisting of:compounds of general formula I [EQU13] wherein R1 and R2 are independently selected from hydrogen, alkyl, alkenyl, alkinyl, and cycloalkyl; R3 is alkyl, alkenyl, alkinyl, or cycloalkyl; R4, R5, R6 and R7 are independently selected from hydrogen, al
1. A compound selected from the group consisting of:compounds of general formula I [EQU13] wherein R1 and R2 are independently selected from hydrogen, alkyl, alkenyl, alkinyl, and cycloalkyl; R3 is alkyl, alkenyl, alkinyl, or cycloalkyl; R4, R5, R6 and R7 are independently selected from hydrogen, alkyl, alkenyl, alkinyl, cycloalkyl, halogen, haloalkyl, hydroxy, aryl, amino, mono- and dialkylamino, alkoxy, cycloalkyloxy, aryloxy, heteroaryloxy, alkylthio, alkylsulfoxyl, alkylsulfonyl, nitro, cyano, alkoxycarbonyl, aryloxycarbonyl, heteroaryloxycarbonyl, heteroaryl, alkylcarbonylamino, arylcarbonylamino, heteroarylcarbonylamino, and carboxyl; the ring A represents a 5 or 6 membered partially unsaturated or saturated carbocyclic or saturated or partially unsaturated heterocyclic ring, wherein the two atoms of the indoline ring to which ring A is fused form a saturated C-C single bond; pharmaceutically acceptable salts of compounds of formula I, and esters of compounds of formula I.
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이 특허에 인용된 특허 (3)
Hadvary Paul (Biel-Benken CHX) Hochuli Erich (Arisdorf CHX) Kupfer Ernst (Basel CHX) Lengsfeld Hans (Reinach CHX) Weibel Ernst K. (Pratteln CHX), Leucine derivatives.
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