초록

Disclosed are novel compounds, and methods of making the same, represented by Structural Formula II, IX or XXVII: [EQU1]The compounds can be used to prepare combinatorial libraries based on a multicomponent Ugi reaction.

대표청구항 ▼

1. A method of preparing an isonitrile, represented by the following structural formula: [EQU32]or salts thereof, wherein:R1 is an amino acid side-chain or a protected amino acid side-chain; R2 is -NR5R6 or -N+≡C-; or R1 and R2, taken together with the methine group to which they are bonded, form a

1. A method of preparing an isonitrile, represented by the following structural formula: [EQU32]or salts thereof, wherein:R1 is an amino acid side-chain or a protected amino acid side-chain; R2 is -NR5R6 or -N+≡C-; or R1 and R2, taken together with the methine group to which they are bonded, form a moiety represented by the following structural formula; [EQU33]R3 is -NH2, -OH, -OC(O)H or -OR9; R5, R6 and R7 are each, independently, -H or an amine protecting group; R8 is -H, -OH or -OR9; and R9 is an alcohol protecting group, comprising the steps of: a) formylating a starting material represented by the following structural formula: [EQU34]to form an N-alkyl formamide represented by the following structural formula: [EQU35]b) dehydrating the N-alkyl formamide, thereby forming said isonitrile.