초록 ▼

The present invention relates to a novel polypeptide, PTP20, and to nucleic acid molecules encoding the polypeptide . The invention also relates to nucleic acid molecules encoding portions of the phosphatase, nucleic acid vectors containing PTP20 related nucleic acid molecules, recombinant cells con

The present invention relates to a novel polypeptide, PTP20, and to nucleic acid molecules encoding the polypeptide . The invention also relates to nucleic acid molecules encoding portions of the phosphatase, nucleic acid vectors containing PTP20 related nucleic acid molecules, recombinant cells containing such nucleic acid vectors, polypeptides purified from such recombinant cells, antibodies to such polypeptides, and methods of identifying compounds that bind PTP20 or abrogate its interactions with natural binding partners. Also disclosed are methods for diagnosing abnormal conditions in an organism with PTP20 related molecules or compounds.

대표청구항 ▼

1. A method of identifying compounds capable of modulating protein tyrosine phosphatase 20 (PTP20) catalytic activity, wherein said method comprises the following steps:(a) adding a compound to cells containing a PTP20 polypeptide in vitro, wherein said polypeptide comprises at least 95% identity to

1. A method of identifying compounds capable of modulating protein tyrosine phosphatase 20 (PTP20) catalytic activity, wherein said method comprises the following steps:(a) adding a compound to cells containing a PTP20 polypeptide in vitro, wherein said polypeptide comprises at least 95% identity to the amino acid sequence from amino acid residues 59 to 294 of SEQ ID NO: 7; and (b) detecting a change in said catalytic activity.