초록 ▼

A formulation for non-invasive delivery of pharmaceutical agents, particularly proteins and peptides, by absorption through a membrane at a targeted site is provided, along with a process of making the formulation. The formulation comprises a suspension of solid-phase dehydrated particles in a deliv

A formulation for non-invasive delivery of pharmaceutical agents, particularly proteins and peptides, by absorption through a membrane at a targeted site is provided, along with a process of making the formulation. The formulation comprises a suspension of solid-phase dehydrated particles in a delivery medium. The particles comprise the dehydration product of the pharmaceutical agent and at least one of a surfactant and permeation enhancer, and the delivery medium preferably comprises a propellant for pressurized aerosol delivery of the formulation. The formulation can be conveniently delivered to the patient's targeted site where the pharmaceutical agent is absorbed through the mucosa to achieve a desired bioavailability.

대표청구항 ▼

1. A formulation for systemic delivery of insulin to a patient through the buccal mucosa, the formulation comprising:a suspension of dehydrated solid particles in a delivery medium wherein the solid particles comprise a dehydration product of the insulin and an orally effective nonsteroidal membrane

1. A formulation for systemic delivery of insulin to a patient through the buccal mucosa, the formulation comprising:a suspension of dehydrated solid particles in a delivery medium wherein the solid particles comprise a dehydration product of the insulin and an orally effective nonsteroidal membrane-permeation enhancer, the delivery medium comprising a fluid, the dehydrated solid particles being suspended in the delivery medium, and adapted for spray delivery of the dehydrated solid particles to the buccal mucosa.