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Method and apparatus for incubation of a liquid reagent and target spots on a microarray substrate 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12Q-001/68
출원번호 US-0897621 (2001-07-02)
발명자 / 주소
  • Mack J. Schermer
  • C. Todd Lombardo
  • Robert Milkowski
  • Donald Regan
  • Paul St. Cyr
출원인 / 주소
  • Packard BioScience Corporation
대리인 / 주소
    Hale and Dorr LLP
인용정보 피인용 횟수 : 37  인용 특허 : 34

초록 ▼

A method and apparatus for incubating a liquid reagent with target spots on a microarray substrate. A deformable cover is placed over the surface of the microarray substrate having the target spots with the liquid reagent between the microarray substrate and the deformable cover, and a device is use

대표청구항 ▼

1. A method for incubating a liquid reagent with target spots on a first surface of a microarray substrate, comprising:confining the liquid reagent in a space between a deformable cover having a gasket and the first surface of the microarray substrate; applying at least first and second forces to th

이 특허에 인용된 특허 (34)

  1. Sugarman Jeffrey J. (Sunnyvale CA) Rava Richard P. (Palo Alto CA) Kedar Haim (Palo Alto CA), Apparatus and method for parallel coupling reactions.
    상세보기
  2. Schembri Carol T. ; Overman Leslie B. ; Hotz Charles Z., Apparatus for conducting chemical or biochemical reactions on a solid surface within an enclosed chamber.
    상세보기
  3. Pomar Longedo Pere,ESX ; Pons Munill Xavier,ESX ; Twose Valls Ivan,ESX ; Alonso Riera Enric,ESX ; Restrepo Guerrero Carlos,ESX ; Perez Puigdomenech Francesc,ESX, Apparatus for performing laboratory tests automatically.
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  4. Copeland Keith G. (Tucson AZ) Grogan Thomas M. (Tucson AZ) Hassen Charles (Tucson AZ) Humphreys William R. (Tucson AZ) Lemme Charles D. (Tucson AZ) Miller Phillip C. (Tucson AZ) Richards William L. (, Automated biological reaction apparatus.
    상세보기
  5. Cathcart G. Richard (San Carlos CA) Brennan-Marquez Thomas (Sunnyvale CA) Bridgham John A. (Hillsborough CA) Golda George S. (El Granada CA) Guiremand Harry A. (Half Moon Bay CA) Hane Marianne (Burli, Automated molecular biology laboratory.
    상세보기
  6. Copeland Keith G. (Tucson AZ) Grogan Thomas M. (Tucson AZ) Hassen Charles (Tucson AZ) Humphreys William Ross (Tucson AZ) Lemme Charles D. (Tucson AZ) Miller Phillip C. (Tucson AZ) Richards William L., Automated slide processing apparatus with fluid injector.
    상세보기
  7. DeWeerd Herman ; Stokes Brian ; Bengtsson Hans ; Honkanen Peter, Bi-directional scanning system with a pixel clock system.
    상세보기
  8. Hugh Mark A., Controlled atmosphere incubator.
    상세보기
  9. Hunnell Jack E. (Durham NC), DNA hybridization incubator.
    상세보기
  10. Yassinzadeh Zia ; Lingane Paul J., Flow detection apparatus and method.
    상세보기
  11. Tam Joseph Wing On,HKX, Flow through nucleic acid hybridisation device.
    상세보기
  12. Ford Anthony ; McDaniel Darin ; Mead Stephen ; Richards William ; Druyor-Sanchez Bobbi ; Heilman Bronwen, Fluid dispenser.
    상세보기
  13. Besemer Donald ; Lobban Peter E. ; Norris Michael C. ; Muller Steven V., Fluidics station with a mounting system and method of using.
    상세보기
  14. Atwood John G. (West Redding CT) Haff Lawrence A. (Wilton CT), In situ PCR amplification system.
    상세보기
  15. Atwood John G. (West Redding CT) Picozza Enrico (Newtown CT), In situ PCR amplification system.
    상세보기
  16. Anderson Rolfe C. ; Lipshutz Robert J. ; Rava Richard P. ; Fodor Stephen P. A., Integrated nucleic acid diagnostic device.
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  17. Anderson Rolfe C. ; Lipshutz Robert J. ; Rava Richard P. ; Fodor Stephen P. A., Integrated nucleic acid diagnostic device.
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  18. Lipshutz Robert J. ; Rava Richard P. ; Anderson Rolfe C. ; Fodor Stephen P. A., Integrated nucleic acid diagnostic device.
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  19. Lipshutz Robert J. ; Rava Richard P. ; Anderson Rolfe C. ; Fodor Stephen P. A., Integrated nucleic acid diagnostic device.
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  20. Trulson Mark (Santa Clara CA) Stern David (Mountain View CA) Fiekowsky Peter (Los Altos CA) Rava Richard (Palo Alto CA) Walton Ian (Menlo Park CA) Fodor Stephen P. A. (Palo Alto CA), Method and apparatus for imaging a sample on a device.
    상세보기
  21. Schembri Carol T., Method and apparatus for mixing a thin film of fluid.
    상세보기
  22. Besemer Donald M. ; Goss Virginia W. ; Winkler James L., Method and apparatus for packaging a probe array.
    상세보기
  23. Smyczek Peter J. (1837 N. Himount Blvd. Milwaukee WI 53208) Thompson John A. (2908 Ward Kline Rd. Myersville MD 21771), Method for conducting nucleic acid hybridization in chamber with precise fluid delivery.
    상세보기
  24. Copeland Keith G. (Tucson AZ) Grogan Thomas M. (Tucson AZ) Miller Phillip C. (Tucson AZ) Richards William L. (Tucson AZ) Showalter Wayne A. (Tucson AZ), Method for mixing reagent and sample mounted on a slide.
    상세보기
  25. Brown Patrick O. ; Shalon Tidhar Dari, Methods for fabricating microarrays of biological samples.
    상세보기
  26. Martinsky Richard S, Microarray printing device including printing pins with flat tips and exterior channel and method of manufacture.
    상세보기
  27. Northrup M. Allen (Berkeley CA) White Richard M. (Berkeley CA), Microfabricated reactor.
    상세보기
  28. Anderson Rolfe C. ; Lipshutz Robert J. ; Rava Richard P. ; Fodor Stephen P. A., Miniaturized genetic analysis systems and methods.
    상세보기
  29. Stapleton Marilyn J. (Durham NC), Process for specimen handling for analysis of nucleic acids.
    상세보기
  30. Kedar Haim, Reaction vessel agitation apparatus.
    상세보기
  31. Chianese David, Reagent strip slide treating apparatus.
    상세보기
  32. Winkler James L. ; Chee Mark ; Lockhart David, Rotational mixing method using a cartridge having a narrow interior.
    상세보기
  33. Meehan Brian W. (616 Wildwood East Lansing MI 48823) Heine Uwe (Department of HLA/Paternity Roche Biomedical Laboratories ; Inc. 1447 York Ct. Burlington NC 27215) Mason James M. (50 Driftwood Ct. Gi, Temperature regulated hybridization chamber.
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  34. Custance Aaron,GBX ; Parker Jonathan I.,GBX, Thermal and fluid cycling device for nucleic acid hybridization.
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이 특허를 인용한 특허 (37)

  1. Matson, Robert S., Analysis using a distributed sample.
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  2. Kram, Brian Howard; Marshall, Kevin David; Otter, Michael; Martin, Carl David; Jones, Jessica, Arcuate member for moving liquids along a microscope slide.
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  3. Kram, Brian Howard; Marshall, Kevin David; Otter, Michael; Martin, Carl David; Jones, Jessica, Arcuate member for moving liquids along a microscope slide.
    상세보기
  4. Cosby, N. Guy; Moore, David J.; Clements, Jim, Cover slip mixing apparatus.
    상세보기
  5. Halverson, Kurt J.; Prabhu, Anila; Botzet, Steven J., Devices, methods and systems for low volume microarray processing.
    상세보기
  6. St. Cyr, Paul L.; DelVecchio, Michael L.; Whitehouse, Craig M., Direct sample analysis device adapters and methods of using them.
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  7. St. Cyr, Paul L.; DelVecchio, Michael L.; Whitehouse, Craig M., Direct sample analysis device adapters and methods of using them.
    상세보기
  8. Erickson, Page A.; Everman, Michael R.; Bell, Michael S.; Edberg, Kevin S.; Botke, Matthew M., Enhanced fluidic method and apparatus for automated rapid immunohistochemistry.
    상세보기
  9. Schleifer,Arthur, Fluid containment structure.
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  10. Erickson, Page A.; Everman, Michael R.; Bell, Michael S.; Edberg, Kevin S.; Sawatzky, Brian D.; Botke, Matthew M., Method and apparatus for automated rapid immunohistochemistry.
    상세보기
  11. Kram, Brian H., Method and apparatus for treating a biological sample with a liquid reagent.
    상세보기
  12. Mann, Karl-Heinz; Mayer, Thomas; Vieth, Friedhelm, Method and device for mixing samples on a support.
    상세보기
  13. Kinoshita, Kenji; Yakabe, Toru; Fujimoto, Kentaro; Yokoyama, Kanehisa; Fujiwara, Kazuhiko, Method of synthesizing cDNA and method of synthesizing RNA chains, and nucleotide-immobilized carrier.
    상세보기
  14. Wolf, Nicholas Adam; Jin, Danliang; Barklund, Anna; Dinu, Raluca, Methods for making and using SPR microarrays.
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  15. Xian, Feijun; Xing, Wanli; Cheng, Jing; Liang, Dong; Zhang, Liang; Wang, Dong, Microarray devices having controllable reaction volume.
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  17. Hahn,Soonkap; Steadman,Jhobe; Tsinberg,Pavel; Watanaskul,Tim; Gerassi,Yehudit, Microarray hybridization device having bubble-fracturing elements.
    상세보기
  18. Schleifer,Arthur; Caren,Michael P, Multiple array format.
    상세보기
  19. Hall, John P., Multiwell apparatus.
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  20. Hall,John P., Multiwell apparatus.
    상세보기
  21. Otter, Michael; Kram, Brian Howard; Martin, Carl David; Jones, Jessica; Marshall, Kevin David; Tse, Christine; Harrison, Josh, Opposables and automated specimen processing systems with opposables.
    상세보기
  22. Erickson, Page A.; Everman, Michael R.; Bell, Michael S.; Edberg, Kevin S.; Botke, Matthew M., Parallel processing fluidic method and apparatus for automated rapid immunohistochemistry.
    상세보기
  23. Pugia, Michael J.; Profitt, James A., Piezo dispensing of a diagnostic liquid into microfluidic devices.
    상세보기
  24. Pugia, Michael J.; Profitt, James A., Piezo dispensing of a diagnostic liquid onto a reagent surface.
    상세보기
  25. Einsle, Xaver; Becker, Horst Dieter; Stratmann, Rembert, Platform.
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  26. Kim, Gibum; Guan, Hannwen; Cong, Shuxin, SPR apparatus with a high performance fluid delivery system.
    상세보기
  27. Kim, Gibum; Guan, Hannwen; Cong, Shuxin, SPR apparatus with a high performance fluid delivery system.
    상세보기
  28. Kim, Gilbum; Guan, Hannwen; Cong, Shuxin, SPR apparatus with a high performance fluid delivery system.
    상세보기
  29. Kim, Gilbum; Guan, Hannwen; Cong, Shuxin, SPR apparatus with a high performance fluid delivery system.
    상세보기
  30. St. Cyr, Paul L; DelVecchio, Michael L.; Weisgable, Leonard J.; Buturla, John T.; Pignataro, Steve M, Sample holders and methods of using them.
    상세보기
  31. St. Cyr, Paul L.; DelVecchio, Michael L., Sample platforms and methods of using them.
    상세보기
  32. Ho,Winston Z., Self-contained microfluidic biochip and apparatus.
    상세보기
  33. Guan, Hann-Wen; Cong, Shuxin, Surface plasmon resonance spectrometer with an actuator driven angle scanning mechanism.
    상세보기
  34. Otake,Gary, Test strip containers and methods of using the same.
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  35. Kram, Brian Howard; Marshall, Kevin David; Tse, Christine; Keller, Timothy James; Ashby, Austin Micheil, Thin film processing apparatuses for adjustable volume accommodation.
    상세보기
  36. Kram, Brian Howard; Marshall, Kevin David; Tse, Christine; Keller, Timothy James; Ashby, Austin Micheil, Thin film processing apparatuses for adjustable volume accommodation.
    상세보기
  37. Erickson, Page A.; Everman, Michael R.; Bell, Michael S.; Edberg, Kevin S.; Botke, Matthew M., Wicking cassette method and apparatus for automated rapid immunohistochemistry.
    상세보기

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