A nail lacquer for the treatment or prevention of fungal infections, such as, onychomycosis, includes fungicidally effective amount of ciclopirox, econazole, or other antifungal agent in a compatible film-forming lacquer vehicle which includes a water-insoluble film-forming polymer; pentadecalactone
A nail lacquer for the treatment or prevention of fungal infections, such as, onychomycosis, includes fungicidally effective amount of ciclopirox, econazole, or other antifungal agent in a compatible film-forming lacquer vehicle which includes a water-insoluble film-forming polymer; pentadecalactone, or similar cyclic lactone compound or derivative thereof, and volatile solvent. The pentadecalactone functions as a plasticizer for the film-forming polymer and as a penetration enhancer for the antifungal agent. The composition, when applied to the nails provides a hard, clear, water-resistant film containing the antifungal agent. The compositions are used for the treatment of onychomycosis.
대표청구항▼
1. A composition effective for the treatment or inhibiting of fungal infections of nails, comprising:(a) at least one antifungal agent effective in the treatment or prevention of onychomycoses; (b) a plasticizing and penetration enhancing effective amount of a compound of the following formula (I):
1. A composition effective for the treatment or inhibiting of fungal infections of nails, comprising:(a) at least one antifungal agent effective in the treatment or prevention of onychomycoses; (b) a plasticizing and penetration enhancing effective amount of a compound of the following formula (I): [EQU11]A is [is] a group having the structure [EQU12]m and n are integers having a value from 1 to 20 and the sum of m+n is not greater than 25, p is an integer having a value of 0 or 1, q is an integer having a value of 0 or 1, r is an integer having a value of 0 or 1, R represents hydrogen or a straight or branched chain alkyl group having from 1 to 6 carbon atoms, and, R1, R2, R3, R4, R5 and R6, each, independently, represent hydrogen or a straight or branched chain alkyl group having from 1 to 6 carbon atoms, with the proviso that only one R1 to R6 may be said alkyl group, and with the further proviso that, when p, q and r have a value of 0, m+n is at least 11; (c) water-insoluble, film-forming polymer; and, (d) volatile solvent; the composition, when applied to nails, forming, upon evaporation of the volatile solvent, a hard, water-resistant film from which the antifungal agent is releasable and becomes available to treat or prevent fungal infection.
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이 특허에 인용된 특허 (15)
Nimni Marcel (2800 Neilson Way #908 Santa Monica CA 90405), Anti-fungal nail lacquer and method therefor.
DeVincentis Teresa J. (Flanders NJ) Dubash Darius D. (Pine Brook NJ) Burnett Debbie L. (Basking Ridge NJ) Ladas Athanasios S. (Parsippany NJ), Antifungal nail solution.
Sun Ying (Somerville NJ) Liu Jue-Chen (Neshanic NJ) Kimbleton Elizabeth S. (Princeton NJ) Wang Jonas C. T. (Robbinsville NJ), Antifungal treatment of nails.
Ferro Alberto (Riehen CHX) Gerhards Jrgen (Arlesheim CHX) Werner Roland (Basle CHX), Antimicotic nail varnish containing amorolfine in quaternary ammonium acrylic copolymer.
Bohn Manfred (Hofheim am Taunus DEX) Dittmar Walter (Hofheim am Taunus DEX) Peil Heinz G. (Bad Nauheim DEX) Futterer Eberhard (Kelkheim DEX) Kraemer Karl (Langen DEX), Antimycotic nail varnish.
Shah Hemanshu S. (Williamsville NY) Genier Susan (Buffalo NY) Yu Cheng D. (Tonawanda NY) Patel Bhiku (Amherst NY), Lauryl alcohol as skin penetration enhancer for topical imidazole agents.
Hayes ; Jr. Jesse C. (Cleveland TN) Dever Gerald R. (Cordova TN) Laughlin Thomas J. (Germantown TN) Schroer ; Jr. Charles F. (Bartlett TN) Wildman Gary C. (Germantown TN), Method for treating onychomycosis.
Bohn Manfred (Hofheim am Taunus DEX) Dittmar Walter (Hofheim am Taunus DEX) Kraemer Karl (Langen DEX) Peil Heinz G. (Bad Nauheim DEX) Futterer Eberhard (Kelkheim DEX), Nail lacquer with antimycotic activity, and a process for the preparation thereof.
Zhang, Jie; Warner, Kevin S.; Ashburn, Michael A.; Rigby, Larry D.; Niu, Suyi, Adhesive peel-forming formulations for dermal delivery of drugs and methods of using the same.
Zhang, Jie; Warner, Kevin S.; Ashburn, Michael A.; Rigby, Larry D.; Niu, Suyi, Adhesive peel-forming formulations for dermal delivery of drugs and methods of using the same.
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