초록 ▼

The present invention relates generally to synthetic polymer compositions that form interpenetrating polymer networks. In a preferred embodiment, the compositions comprise two multifunctionally activated synthetic polymers, along with a tensile strength enhancer. Such compositions form matrices that

The present invention relates generally to synthetic polymer compositions that form interpenetrating polymer networks. In a preferred embodiment, the compositions comprise two multifunctionally activated synthetic polymers, along with a tensile strength enhancer. Such compositions form matrices that exhibit superior cohesive strength and in many instances can serve as adequate replacements for surgical means of attaching tissues, such as sutures and medical staples.

대표청구항 ▼

1. A composition for forming a matrix useful as a high strength medical sealant, wherein said matrix-forming composition comprises:a) a first multifunctional synthetic polymer having a core and m functional groups, X; b) a multifunctional crosslinker having n functional groups, Y, wherein the sum of

1. A composition for forming a matrix useful as a high strength medical sealant, wherein said matrix-forming composition comprises:a) a first multifunctional synthetic polymer having a core and m functional groups, X; b) a multifunctional crosslinker having n functional groups, Y, wherein the sum of m and n is greater than or equal to 5, and X and Y react to form a covalent crosslink Z upon admixture of the first multifunctional synthetic polymer and the multifunctional crosslinker; and c) a tensile strength enhancer comprised of a fibrous material selected from the group consisting of polyglycolide, polylactide, polyglycolide-polylactide copolymers, glass wool, plastics, resins, and combinations thereof, wherein the high strength medical sealant formed by reaction of the first multifunctional synthetic polymer with the multifunctional crosslinker has at least 10% of the tensile strength of cyanoacrylate.