초록 ▼

A milk product providing an individual at least 31 IU (International Units) of vitamin E per serving, or an ingestible blend of at least one mammalian milk protein or fragment thereof, and vitamin E or other fat-soluble micronutrient or pharmacological agent is described. The vitamin E is uniformly

A milk product providing an individual at least 31 IU (International Units) of vitamin E per serving, or an ingestible blend of at least one mammalian milk protein or fragment thereof, and vitamin E or other fat-soluble micronutrient or pharmacological agent is described. The vitamin E is uniformly microdispersed throughout the milk product, and ingestion of at least 100 IU of vitamin E per day in the product is sufficient to cause the fasting plasma vitamin E/cholesterol ratio in human subjects to be elevated at least 50% above the basal fasting level of vitamin E measured in the same subjects consuming no vitamin E dietary supplements. A method for elevating the plasma vitamin E level at least 50% in human subjects is also described. The method includes ingesting a milk product as described. A method for increasing the bioavailability of an orally administered fat-soluble micronutrient or pharmaceutical agent is also described. The method includes providing a microdispersed mixture of at least one fat-soluble micronutrient or pharmaceutical agent, and at least one mammalian milk protein or fragment thereof, in which the weight ratio of the milk protein to the micronutrient or pharmaceutical agent is between 1:1 and 1000:1.

대표청구항 ▼

A milk product providing an individual at least 31 IU (International Units) of vitamin E per serving, or an ingestible blend of at least one mammalian milk protein or fragment thereof, and vitamin E or other fat-soluble micronutrient or pharmacological agent is described. The vitamin E is uniformly

A milk product providing an individual at least 31 IU (International Units) of vitamin E per serving, or an ingestible blend of at least one mammalian milk protein or fragment thereof, and vitamin E or other fat-soluble micronutrient or pharmacological agent is described. The vitamin E is uniformly microdispersed throughout the milk product, and ingestion of at least 100 IU of vitamin E per day in the product is sufficient to cause the fasting plasma vitamin E/cholesterol ratio in human subjects to be elevated at least 50% above the basal fasting level of vitamin E measured in the same subjects consuming no vitamin E dietary supplements. A method for elevating the plasma vitamin E level at least 50% in human subjects is also described. The method includes ingesting a milk product as described. A method for increasing the bioavailability of an orally administered fat-soluble micronutrient or pharmaceutical agent is also described. The method includes providing a microdispersed mixture of at least one fat-soluble micronutrient or pharmaceutical agent, and at least one mammalian milk protein or fragment thereof, in which the weight ratio of the milk protein to the micronutrient or pharmaceutical agent is between 1:1 and 1000:1. 10)aryl(C1-C6)alkyl; and one or more subunits of the formula (II): wherein each R3is independently hydrogen, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, or (C6-C10)aryl(C1-C6)alkyl; and R4is independently (C2-C20)alkyl. 9. The polymer of claim 8 wherein R1is independently (CH2)4,(CH2)8,or (CH2)12. 10. The polymer of claim 8 wherein R2is independently hydrogen or benzyl. 11. The polymer of claim 8 wherein each R3is independently iso-butyl or benzyl. 12. The polymer of claim 8 wherein R4is independently (CH2)4,(CH2)6,(CH2)8,or (CH2)12. 13. The polymer of claim 8 that is a polymer of formula (VII): wherein m is about 0.1 to about 0.9; p is about 0.9 to about 0.1; and n is about 50 to about 150. 14. The polymer of claim 13 wherein p/(p+m) is about 0.9 to about 0.1. 15. The polymer of claim 13 wherein m/(p+m) is about 0.1 to about 0.9. 16. A polymer of formula (VII) formed from an amount of one or more compounds of formula (III): wherein each R3is independently hydrogen, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, or (C6-C10)aryl(C1-C6)alkyl; and R4is independently (C2-C20)alkyl; or a suitable salt thereof; an amount of one or more compounds of formula (IV): wherein R2is independently hydrogen, or (C6-C10)aryl(C1-C6)alkyl; or a suitable salt thereof; and an amount of one or more compounds of formula (V): wherein R1is independently (C2-C20)alkyl; and each R5is independently (C6-C10)aryl optionally substituted with one or more nitro, cyano, halo, trifluoromethyl, or trifluoromethoxy. 17. The polymer of claim 16 wherein R1is independently (CH2)4,(CH2)8,or (CH2)12. 18. The polymer of claim 16 wherein R2is independently hydrogen or benzyl. 19. The polymer of claim 16 wherein each R3is independently iso-butyl or benzyl. 20. The polymer of claim 16 wherein R4is independently (CH2)4,(CH2)6,(CH2)8,or (CH2)12. 21. The polymer of claim 16 wherein each R5is p-nitrophenyl. 22. The polymer of claim 16 wherein the compound of formula (III) is the di-p-tolunesulfonic acid salt of a bis-(L-α-amino acid)-α,ω-alkylene diester. 23. The polymer of claim 16 wherein the compound of formula (IV) is the di-p-tolunesulfonic acid salt of L-lysine benzyl ester. 24. The polymer of claim 16 wherein the compound of formula (V) is di-p-nitrophenyl adipate, di-p-nitrophenyl sebacinate, or di-p-nitrophenyl dodecyldicarboxylate. 25. The polymer of claim 16 that is a polymer of formula (VII): wherein m is about 0.1 to about 0.9; p is about 0.9 to about 0.1; and n is about 50 to about 150. 26. The polymer of claim 25 wherein p/(p+m) is about 0.9 to about 0.1. 27. The polymer of claim 25 wherein m/(p+m) is about 0.1 to about 0.9. 28. A method for preparing a polymer of formula (VII): wherein m is about 0.1 to about 0.9; p is about 0.9 to about 0.1; n is about 50 to about 150; each R1is independently (C2-C20)alkyl; each R2is independently hydrogen, or (C6-C10)aryl(C1-C6)alkyl; each R3is independently hydrogen, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, or (C6-C10)aryl(C1-C6)alkyl; and each R4is independently (C2-C20)alkyl; comprising contacting an amount of one or more compounds of formula (III): or a suitable salt thereof; an amount of one or more compounds of formula (IV): or a suitable salt thereof; and an amount of one or more compounds of formula (V): wherein each R5is independently (C6-C10)aryl optionally substituted with one or more nitro, cyano, halo, trifluoromethyl, or trifluoromethoxy; under suitable conditions to provide the polymer of formula (VII). 29. The method of claim 28 wherein each R1is independently (CH2)4,(CH2)8,or (CH2)12. 30. The method of claim 28 wherein each R2is independently hydrogen or benzyl. 31. The method of claim 28 wherein each R3is independently iso-butyl or benzyl. 32. The method of claim 28 wherein each R4is independently (CH2)4,(CH2)6,(CH2)8,or (CH2)12. 33. The method of claim 28 wherein each R5is p-nitrophenyl. 34. The method of claim 28 wherein the compound of formula (III) is the di-p-tolunesulfonic acid salt of a bis-(L-α-amino acid)-α,ω-alkylene diester. 35. The method of claim 28 wherein the compound of formula (IV) is the di-p-tolunesulfonic acid salt of L-lysine benzyl ester. 36. The method of claim 28 wherein the compound of formula (V) is di-p-nitrophenyl adipate, di-p-nitrophenyl sebacinate, or di-p-nitrophenyl dodecyldicarboxylate. 37. The method of claim 28 wherein the contacting is carried out in the presence of a base. 38. The method of claim 37 wherein the base is triethylamine. 39. The method of claim 28 wherein the contacting is carried out in the presence of a solvent. 40. The method of claim 39 wherein the solvent is N,N-dimethylacetamide. 41. The method of claim 28 wherein the contacting is carried out at about 50° C. to about 100° C. 42. The method of claim 28 wherein the contacting occurs for about 10 hours to about 24 hours. 43. The method of claim 28 further comprising purifying the polymer of formula (VII). 44. The method of claim 28 wherein p/(p+m) is about 0.9 to about 0.1. 45. The method of claim 28 wherein m/(p+m) is about 0.1 to about 0.9. 46. A polymer of formula (XI): wherein m is about 0.1 to about 0.9; p is about 0.9 to about 0.1; n is about 50 to about 150; each R2is independently hydrogen, or (C6-C10)aryl(C1-C6)alkyl; each R3is independently hydrogen, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, or (C6-C10)aryl(C1-C6)alkyl; each R4is independently (C2-C20)alkyl; and each R6is independently (C2-C20)alkyl or (C2-C8)alkyloxy(C2-C20)alkyl. 47. The polymer of claim 46 wherein each R2is independently hydrogen or benzyl. 48. The polymer of claim 46 wherein each R3is independently iso-butyl or benzyl. 49. The polymer of claim 46 wherein each R4is independently (CH2)4,(CH2)6,(CH2)8,or (CH2)12. 50. The polymer of claim 46 wherein each R6is independently (CH2)3or (CH2)2--O--(CH2)2. 51. The polymer of claim 46 wherein p/(p+m) is about 0.9 to about 0.1. 52. The polymer of claim 46 wherein m/(p+m) is about 0.1 to about 0.9. 53. A polymer of formula (XI) comprising one or more subunits of the formula (VIII): wherein