초록 ▼

A densification and storage system for fluids is provided by multitudes of closely spaced parallel planes of adsorptive material (88) that is contained within a substantially impervious barrier layer (2). In normal pressure-containing embodiments, reinforcement (4) is wrapped upon the impervious bar

A densification and storage system for fluids is provided by multitudes of closely spaced parallel planes of adsorptive material (88) that is contained within a substantially impervious barrier layer (2). In normal pressure-containing embodiments, reinforcement (4) is wrapped upon the impervious barrier layer (2) to increase the burst strength of the assembly that results. In higher pressure containing embodiments, material (88) provides reinforcement of barrier layer (2).

대표청구항 ▼

A densification and storage system for fluids is provided by multitudes of closely spaced parallel planes of adsorptive material (88) that is contained within a substantially impervious barrier layer (2). In normal pressure-containing embodiments, reinforcement (4) is wrapped upon the impervious bar

A densification and storage system for fluids is provided by multitudes of closely spaced parallel planes of adsorptive material (88) that is contained within a substantially impervious barrier layer (2). In normal pressure-containing embodiments, reinforcement (4) is wrapped upon the impervious barrier layer (2) to increase the burst strength of the assembly that results. In higher pressure containing embodiments, material (88) provides reinforcement of barrier layer (2). of Duck Hepatitis B Virus Pregenomic RNA", Journal of Virology, vol. 65, No. 6, Jun. 1991, pp 3309-3316, XP000614651. Korba et al.: "Antisense Oligonucleotides are effective inhibitors of hepatitis B v irus replication in vitro", antiviral research, vol. 28, 1995, pp 225-242, XP00063334. Agrawal, S., et al. "Pharmacokinetics of Antisense Oligonucleotides,"Clin. Pharmacokinet, 28:7-1 (1995). Bartholomew, R. M., et al. "Targeted Delivery Of Antisense DNA In Woodchuck Hepatitis Virus-Infected Woodchucks,"J. Viral Heptitis, 2:273-278 (1995). Bassendine, M.F., et al. "Adenine Arabinoside Therapy in HBeAg-Positive Chronic Liver Disease: A Controlled Study,"Gastroenterol, 80:1016-1020 (1981). Bayever, E., et al. "Systemic Administration of a Phosphorthioate Oligonucleotide with a Sequence Complementary to p53 for Acute Myelogenous Leukemia and Myelodysplastic Syndrome: Initial Results of a Phase I Trial,"Antisense Res. Dev., 3:383-90 (1993). Cunningham, C. Casey, et al. "A Phase I Trial of c-Raf Kinase Antisense Olignucleotide ISIS 5132 Administered as a Continuous Intravenous Infusion in Patients with Advanced Cancer," Clin, Cancer Res., 6:1626-31 (May 2000). Dean, Nicolas M., et al. "Inhibition of Protein Kinase C-α Expression in Human A549 Cells by Antisense Oligonucleotides Inhibits Induction of Intercellular Adhesion Molecule 1 (ICAM-1) mRNA by Phorbol Ester," J. Biol. Chem., 269:16416-16424 (Jun. 1994). Diapola, Robert S., et al., "Evidence For A Functional Kit Receptor In Melanoma, Breast, And Lung Carcinoma Cells," Cancer Gene Therapy4(3):176-182 (1997). Field, A.K. "Viral Targets For Antisense Oligonucleotides: A Mini Review," Antiviral Res., 37:67-81 (1998). Fourel, I., et al. "Effects of 2'-Fluorinated Arabinosyl-Pyrimidine Nucleosides on Duch Hepatitis B Virus DNA Level in Serum and Liver of Chronically Infected Ducks,"J. Med Virol., 37:122-126 (1992). Fried, Michael W., et al. "Therapy of Chronic Hepatitis B with a 6-Month Course of Ribavirin," J. Hepatol., 21:145-150 (1994). Galderisi, Umnerto, et al. "Antisense Oligonucleotides as Therapeutic Agents," J. Cell. Physiol., 181:251-257 (1999). Gangemi, J. David, et al. "Antiviral and Anti-Proliferative Activities of .A-inverted.Interferons in Experimental Hepatitis B Virus Infections,"Antiviral Therapy, 1:64-70 (1997). Gerin, John L., et al. "A Preliminary Report of A Controlled Study of Thymosin Alpha-1 in the Woodchuck Model of Hepadnavirus Infection," in Advances in Antiviral Drug Development and Detection of Virus Infections, New York: Plenum Press, (1992) pp. 121-123. Hadziyannis, S., et al. "Interferon Treatment With or Without Oral Granciclovir in HBeAg-Negative Chronic Hepatitis B: A Randomized Study,