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Terminally sterilized osteogenic devices and preparation thereof 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61L-027/00
  • A61L-002/14
  • A61F-013/00
  • A01N-037/18
  • C08L-089/00
출원번호 US-0954748 (2001-09-18)
발명자 / 주소
  • Tucker, Marjorie M.
  • Rueger, David C.
  • Sampath, Kuber T.
출원인 / 주소
  • Stryker Corporation
대리인 / 주소
    Testa, Hurwitz & Thibeault, LLP
인용정보 피인용 횟수 : 48  인용 특허 : 36

초록 ▼

Disclosed are terminally sterilized osteogenic devices for implantation into a mammal. The devices contain a combination of a biologically active osteogenic protein and an insoluble carrier which after being combined are sterilized by exposure to ionizing radiation, for example, by exposure to gamma

대표청구항 ▼

Disclosed are terminally sterilized osteogenic devices for implantation into a mammal. The devices contain a combination of a biologically active osteogenic protein and an insoluble carrier which after being combined are sterilized by exposure to ionizing radiation, for example, by exposure to gamma

이 특허에 인용된 특허 (36)

  1. Kuberasampath Thangavel ; Pang Roy H. L. ; Oppermann Hermann ; Rueger David C. ; Cohen Charles M., 60A protein-induced morphogenesis.
    상세보기
  2. Urist Marshall R. (Pacific Palisades CA), Assay of Bone morphogenetic protein (BMP) and anti-BMP antibody for the diagnosis of bone disorders.
    상세보기
  3. Mikos Antonios G. (Houston TX), Biodegradable bone templates.
    상세보기
  4. Silver Frederick A. (Long Valley NJ) Berg Richard A. (Lambertville NJ) Birk David E. (Somerset NJ) Weadock Kevin (Piscataway NJ) Whyne Conrad (Somerset NJ), Biodegradable matrix and methods for producing same.
    상세보기
  5. Jefferies Steven R. (5802 Leith Walk Baltimore MD 21239), Bone graft material for osseous defects and method of making same.
    상세보기
  6. Chu George H. (Sunnyvale CA) Ogawa Yasushi (Pacifica CA) McPherson John M. (Hopkinton MA) Ksander George (Redwood City CA) Pratt Bruce (Union City CA) Hendricks Diana (Brea CA) McMullin Hugh (San Bru, Collagen wound healing matrices and process for their production.
    상세보기
  7. Tjia Jane S. (Malden MA) Kelley Brian D. (Medford MA) Northey Richard P. (Ipswich MA) Philbrook C. Michael (Boston MA), Formulations for delivery of osteogenic proteins.
    상세보기
  8. Yim Kalvin W. K. (N. andover MA) Huberty Michael C. (Andover MA) Northey ; Jr. Richard P. (Ipswich MA) Schrier Jay A. (Andover MA), Formulations for delivery of osteogenic proteins.
    상세보기
  9. Ron Eyal (Lexington MA) Schaub Robert G. (Pelham NH) Turek Thomas J. (Boston MA), Formulations of blood clot-polymer matrix for delivery of osteogenic proteins.
    상세보기
  10. Smestad Thomas L. (Palo Alto CA) Prows Daniel (Los Gatos CA) Chu George H. (Cupertino CA) Hendericks Diana M. (Brea CA) Brown Debera (Palo Alto CA), Gamma irradiation of collagen/mineral mixtures.
    상세보기
  11. Smestad Thomas L. (Palo Alto CA) Prows Daniel (Santa Clara CA) Chu George H. (Sunnyvale CA) Hendricks Diana M. (Brea CA), Gamma irradiation of collagen/mineral mixtures.
    상세보기
  12. Smestad, Thomas L.; Prowse, Daniel; Chu, George H.; Hendricks, Diana M., Gamma irradiation of collagen/mineral mixtures.
    상세보기
  13. Chu George (Sunnyvale CA) Nathan Ranga (Newark CA) Seyedin Saeid (Mountain View CA), Inductive collagen-based bone repair preparations.
    상세보기
  14. Khouri Roger K. ; Sampath Kuber T. ; Rueger David C., Manufacture of autogenous replacement body parts.
    상세보기
  15. Khouri Roger K. ; Sampath Kuber T. ; Rueger David C., Manufacture of autogenous replacement body parts.
    상세보기
  16. Hunziker Ernst B. (Riedholz CHX), Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone.
    상세보기
  17. Oppermann Hermann ; Ozkaynak Engin ; Kuberasampath Thangavel ; Rueger David C. ; Pang Roy H. L., Nucleic acids encoding osteogenic proteins.
    상세보기
  18. Oppermann Hermann (Medway MA) Ozkaynak Engin (Milford MA) Kuberasampath Thangavel (Medway MA) Rueger David C. (Hopkinton MA) Pang Roy H. L. (Etna NH) Cohen Charles M. (Medway MA), OP-3-induced morphogenesis.
    상세보기
  19. O\Leary Robert K. (Spring Lake NJ) Prewett Annamarie B. (Little Silver NJ), Osteogenic composition and implant containing same.
    상세보기
  20. Kuberasampath Thangavel (Medway MA) Rueger David C. (West Roxbury MA), Osteogenic devices.
    상세보기
  21. Oppermann Hermann (Medway MA) Kuberasampath Thangavel (Medway MA) Rueger David C. (West Roxbury MA) Ozkaynak Engin (Milford MA), Osteogenic devices.
    상세보기
  22. Sen Arup (Los Angeles CA), Osteogenic factors.
    상세보기
  23. Damien Christopher J. (Denver CO) Benedict James J. (Golden CO) Poser James W. (Lawrenceville NJ), Osteogenic product and process.
    상세보기
  24. Oppermann Hermann (Medway MA) Ozkaynak Engin (Milford MA) Kuberasampath Thangavel (Medway MA) Rueger David C. (Hopkinton MA) Pang Roy H. L. (Medway MA), Osteogenic proteins.
    상세보기
  25. Kuberasampath Thangavel (Medway MA) Rueger David C. (West Roxbury MA), Osteogenic proteins and polypeptides.
    상세보기
  26. Wang Elizabeth A. (Carlisle MA) Wozney John M. (Hudson MA) Rosen Vicki (Boston MA), Osteoinductive factors.
    상세보기
  27. Ron Eyal (Lexington MA) Turek Thomas J. (Boston MA) Isaacs Benjamin S. (Tewksbury MA) Patel Himakshi (Tewksbury MA) Kenley Richard A. (Andover MA), Pharmaceutical formulations of osteogenic proteins.
    상세보기
  28. Hollinger Jeffrey O. (Glenwood MD), Polylactic-polyglycolic acids combined with an acidic phospholipid-lysozyme complex for healing osseous tissue.
    상세보기
  29. Heggeness Michael H. (3301 Drummond Houston TX 77025) Doherty Brian J. (350 Sharon Park Dr. Apt. E 39 Menlo Park CA 94025), Prosthetic intervertebral devices.
    상세보기
  30. Israel David ; Wolfman Neil M., Recombinant bone morphogenetic protein heterodimers.
    상세보기
  31. Keck Peter C. ; Smart John E., Single chain analogs of the TGF-.beta. superfamily (morphons).
    상세보기
  32. MacPhee Martin James ; Drohan William Nash ; Woolverton Christoper J., Supplemented and unsupplemented tissue sealants, methods of their production and use.
    상세보기
  33. Kuberasampath Thangavel (Medway MA) Tarrant Lawrence Berlowitz (Harvard MA), Synthetic bone matrix.
    상세보기
  34. Tucker Marjorie M. (Holliston MA) Rueger David C. (Southborough MA) Sampath Kuber T. (Holliston MA), Terminally sterilized osteogenic devices and preparation thereof.
    상세보기
  35. Tucker Marjorie M. ; Rueger David C. ; Sampath Kuber T., Terminally sterilized osteogenic devices and preparation thereof.
    상세보기
  36. Tucker Marjorie M. ; Rueger David C. ; Sampath Kuber T., Terminally sterilized osteogenic devices and preparation thereof.
    상세보기

이 특허를 인용한 특허 (48)

  1. Yao, Jian Q.; Walthall, Ben; Gao, Jizong; Zaporojan, Victor, Apparatus for forming an implant.
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  2. Thorne, Kevin J., Bone growth particles and osteoinductive composition thereof.
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  3. Akella, Rama; Garrett, Ian Ross; Wen, Hai Bo; Li, Shuliang; Acker, Dean M.; Wilhelm, Nichole, Bone void fillers.
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  4. Kizer, Neil; Spiro, Robert; Yao, Jian; Blanchard, Cheryl Renee, Cadaveric allogenic human juvenile cartilage implant.
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  5. Semler, Eric J.; Shikhanovich, Roman; Callahan, Alex B.; Truncale, Katherine Gomes; Yannariello-Brown, Judith I.; Huang, Yen-Chen, Cancellous construct with support ring for repair of osteochondral defects.
    상세보기
  6. Truncale, Katherine G.; Semler, Eric J.; Gertzman, Arthur A.; Sunwoo, Moon Hae; Tomford, William W.; Shikhanovich, Roman, Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles.
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  7. Truncale, Katherine Gomes; Gertzman, Arthur A.; Sunwoo, Moon Hae; Tomford, William W, Cartilage allograft plug.
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  8. Blahut, Eric, Cell and tissue culture container.
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  9. Smith, R. Lane; Tarrant, Laurence J. B.; Kusanagi, Akihiko; Claesson, Hans P. I., Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof.
    상세보기
  10. Thorne, Kevin J., Composition and process for bone growth and repair.
    상세보기
  11. Masinaei, Leila; Wolfinbarger, Jr., Lloyd, Composition for repair of defects in osseous tissues.
    상세보기
  12. Masinaei,Leila; Wolfinbarger, Jr.,Lloyd, Composition for repair of defects in osseous tissues.
    상세보기
  13. Masinaei, Leila; Wolfinbarger, Jr., Lloyd, Compositions for repair of defects in osseous tissues, and methods of making the same.
    상세보기
  14. Masinaei, Leila; Wolfinbarger, Jr., Lloyd, Compositions for repair of defects in osseous tissues, and methods of making the same.
    상세보기
  15. Masinaei, Leila; Wolfinbarger, Jr., Lloyd, Compositions for repair of defects in osseous tissues, and methods of making the same.
    상세보기
  16. Masinaei,Leila; Wolfinbarger, Jr.,Lloyd, Compositions for repair of defects in osseous tissues, and methods of making the same.
    상세보기
  17. Masinaei, Leila; Wolfinbarger, Jr., Lloyd; Chen, Silvia S.; Jones, Alyce Linthurst; Chen, Jingsong, Compositions for repair of defects in tissues, and methods of making the same.
    상세보기
  18. Carter, Andrew J.; Scarborough, Nelson L.; Patt, Bradley, Demineralized bone fibers having controlled geometry and shapes and methods thereof.
    상세보기
  19. Scarborough, Nelson L.; Patt, Bradley; Carter, Andrew J., Demineralized bone fibers having controlled geometry and shapes and methods thereof.
    상세보기
  20. Evans, Douglas G.; Goldman, Scott M.; Kronengold, Russell T., Devices and methods for treating defects in the tissue of a living being.
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  21. Evans, Douglas G; Goldman, Scott M.; Kronengold, Russell T., Devices and methods for treating defects in the tissue of a living being.
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  22. Evans, Douglas G; Goldman, Scott M.; Kronengold, Russell T., Devices and methods for treating defects in the tissue of a living being.
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  23. Evans, Douglas G; Goldman, Scott M.; Kronengold, Russell T., Devices and methods for treating defects in the tissue of a living being.
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  24. Evans, Douglas G; Goldman, Scott M.; Kronengold, Russell T., Devices and methods for treating defects in the tissue of a living being.
    상세보기
  25. Evans, Douglas G; Goldman, Scott M.; Kronengold, Russell T., Devices and methods for treating defects in the tissue of a living being.
    상세보기
  26. McKay, William F.; Peckham, Steven M., Flowable carrier compositions and methods of use.
    상세보기
  27. Sofia, Susan J.; Schwartz, Daniel; Friess, Wolfgang, Formulation comprising bioactive agents and method of using same.
    상세보기
  28. Truncale, Katherine G.; Sunwoo, Moon Hae; Gertzman, Arthur A.; Tomford, William W., Glue for cartilage repair.
    상세보기
  29. Benedict, James J.; Damien, Christopher J., Implantable putty material.
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  30. Gage, Gary; Adkisson, IV, H. Davis; Blanchard, Cheryl R., Implants and methods for repair, replacement and treatment of disease.
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  31. Reddi, A. Hari, Irradiated implantable bone material.
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  32. Reddi, A. Hari, Irradiated implantable bone material.
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  33. Kizer, Neil; Spiro, Robert; Yao, Jian; Blanchard, Cheryl Renee, Juvenile cartilage composition.
    상세보기
  34. Phillips, Frank Martin, Method of intervertebral disc treatment using articular chondrocyte cells.
    상세보기
  35. Yao, Jian Q.; Zaporojan, Victor, Method of obtaining viable small tissue particles and use for tissue repair.
    상세보기
  36. Kizer, Neil; Spiro, Robert; Yao, Jian; Blanchard, Cheryl Renee, Method of treating an osteochondral defect.
    상세보기
  37. Oppermann, Hermann; Ozkaynak, Engin; Kuberasampath, Thangavel; Rueger, David C.; Pang, Roy H. L., Osteogenic devices.
    상세보기
  38. Rueger, David C.; Tucker, Marjorie M., Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects.
    상세보기
  39. Rueger, David C.; Tucker, Marjorie M.; Chang, An-Cheng, Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects.
    상세보기
  40. Rueger, David C.; Tucker, Marjorie M.; Chang, An-Cheng, Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects.
    상세보기
  41. Oppermann,Hermann; Ozkaynak,Engin; Kuberasampath,Thangavel; Rueger,David C.; Pang,Roy H. L., Osteogenic proteins.
    상세보기
  42. Kizer, Neil; Spiro, Robert; Yao, Jian; Blanchard, Cheryl Renee, Particulate cadaveric allogenic cartilage system.
    상세보기
  43. Kizer, Neil; Spiro, Robert; Yao, Jian; Blanchard, Cheryl Renee, Particulate cartilage system.
    상세보기
  44. McKay, William F., Rigid bone graft substitute.
    상세보기
  45. Yao, Jian Q.; Wang, Hali, Supports and methods for promoting integration of cartilage tissue explants.
    상세보기
  46. Kizer, Neil; Spiro, Robert; Yao, Jian; Blanchard, Cheryl Renee, Treatment methods using a particulate cadaveric allogenic juvenile cartilage particles.
    상세보기
  47. Kuberasampath,Thangavel; Cohen,Charles M.; Oppermann,Herrmann; Ozkaynak,Engin; Rueger,David C.; Smart,John E.; Pang,Roy H. L., Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases.
    상세보기
  48. Semler, Eric J.; Truncale, Katherine G.; Callahan, Alex B.; Yannariello-Brown, Judith I., Two piece cancellous construct for cartilage repair.
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