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Novel polymer-supported quenching reagents of Formula I, P--L--Q I wherein P is a polymer of low chemical reactivity which is soluble or insoluble; Q is one or more quenching reagents, or an acid or base addition salts thereof, that are capable of selective covalent reaction with unwanted bypro

Novel polymer-supported quenching reagents of Formula I, P--L--Q I wherein P is a polymer of low chemical reactivity which is soluble or insoluble; Q is one or more quenching reagents, or an acid or base addition salts thereof, that are capable of selective covalent reaction with unwanted byproducts, or excess reagents; and L is one or more chemically robust linkers that join P and Q; are described, as well as methods for their preparation and methods for their use in the rapid purification of synthetic intermediates and products in organic synthesis, combinatorial chemistry and automated organic synthesis.

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1. A method for enhancing the purity of a solid compound which comprises: step (a) treating a crude reaction product which contains the solid compound, unreacted starting materials and/or byproducts with at least one polymer-supported quenching reagent of Formula I, P--L--Q I wherein P is

1. A method for enhancing the purity of a solid compound which comprises: step (a) treating a crude reaction product which contains the solid compound, unreacted starting materials and/or byproducts with at least one polymer-supported quenching reagent of Formula I, P--L--Q I wherein P is a polymer of low chemical reactivity which is soluble or insoluble; Q is selected from the group consisting of NHCH2CH2N(CH2CH2NH2)2,O(CH2)3CHO, O-(3-formylpheny), NHC(=S)NH2,NHCH2CH2SH, 1-thiomorpholine, and 1-maleimide; L is a group between P and Q selected from the group consisting of CH2--N, --CH2-- and --CH2--CH2--O; step (b) allowing the polymer-supported quenching reagent to covalently react with unreacted starting materials and/or byproducts to afford a derivatized reagent of Formula II, P--L--Q--X II wherein X is unreacted starting material and/or byproduct and P, L, and Q are as defined above; and step (c) separating the reagents of Formula I and Formula II from the solution and removing solvent to afford a solid compound of enhanced purity. 2. A method according to claim 1 wherein the crude reaction product is the result of a chemical transformation that is selected from O- and N-acylation; O- and N-sulfonylation; O- and N-phosponylation; O- and N-phoshorylation; C-, O-, N- and S-alkylation; condensation reactions; coupling reactions; and cyclization reactions involving two or more components. 3. A method according to claim 1 wherein the crude reaction product is the result of more than one synthetic step. 4. A method according to claim 1 wherein the reaction mixture is the result of a combinatorial synthesis and contains multiple desired products, multiple unreacted starting materials, and/or multiple byproducts. 5. A method according to claim 1 wherein an insoluble compound of Formula I is used in combination with one or more insoluble materials selected from ion-exchange resins; chelating resins; silica gel; reversed-phase adsorbents; alumina and activated charcoal. 6. A method according to claim 1 wherein an insoluble compound of Formula I is used, and compounds of Formulae I and II are separated from the solution by filtration. 7. A method according to claim 1 wherein an insoluble compound of Formula I is used, and the solution is separated from compounds of Formulae I and II by aspiration. 8. A method according to claim 1 wherein a soluble compound of Formula I is used in Step (a), and the soluble compounds of Formulae I and II are first precipitated and then removed by filtration in Step (c). 9. A method according to claim 1 wherein an insoluble compound of Formula I is packed into solid-phase extraction columns, and the reaction mixture is passed through the column at least once. 10. A method according to claim 1 wherein an insoluble compound of Formula I is attached to the interior surface of a capillary column, and the reaction mixture is passed through the column at least once. 11. A method according to claim 1 wherein the polymer-supported quenching reagent is prepared in the form of a filter disc, and the reaction mixture is passed through the disc at least once. 12. A method according to claim 1 wherein the polymer-supported quenching reagent is prepared in the form of a membrane, and the reaction mixture is passed through the membrane at least once. 13. A method according to claim 1 wherein an insoluble polymer-supported quenching reagent is placed inside an apparatus in order to facilitate parallel purification of multiple crude products. 14. A method according to claim 1 wherein polymer-supported quench is used to facilitate the rapid purification of libraries of organic molecules with potential biological activity.